Browse our anti-Presenilin 1 (PSEN1) Antibodies

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anti-Presenilin 1 Antibodies (PSEN1)
On are 269 Presenilin 1 (PSEN1) Antibodies from 29 different suppliers available. Additionally we are shipping Presenilin 1 Kits (33) and Presenilin 1 Proteins (12) and many more products for this protein. A total of 331 Presenilin 1 products are currently listed.
AD3, Ad3h, FAD, pre1, PS-1, PS1, psen, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1
list all antibodies Gene Name GeneID UniProt
PSEN1 5663 P49768
PSEN1 19164 P49769
PSEN1 29192 P97887

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anti-Human Presenilin 1 Antibodies:

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Top referenced anti-Presenilin 1 Antibodies

  1. Human Polyclonal Presenilin 1 Primary Antibody for EIA, IHC (p) - ABIN358721 : Marambaud, Wen, Dutt, Shioi, Takashima, Siman, Robakis: A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. in Cell 2003 (PubMed)
    Show all 5 references for 358721

  2. Human Polyclonal Presenilin 1 Primary Antibody for IHC, ELISA - ABIN1532166 : Sherrington, Rogaev, Liang, Rogaeva, Levesque, Ikeda, Chi, Lin, Li, Holman, Tsuda, Mar, Foncin, Bruni, Montesi, Sorbi, Rainero, Pinessi, Nee, Chumakov, Pollen, Brookes, Sanseau, Polinsky, Wasco et al.: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. ... in Nature 1995 (PubMed)
    Show all 2 references for 1532166

  3. Human Polyclonal Presenilin 1 Primary Antibody for IHC, ELISA - ABIN1533189 : Heilig, Eckenberg, Petit, Fonknechten, Da Silva, Cattolico, Levy, Barbe, de Berardinis, Ureta-Vidal, Pelletier, Vico, Anthouard, Rowen, Madan, Qin, Sun, Du, Pepin, Artiguenave, Robert, Cruaud, Brüls et al.: The DNA sequence and analysis of human chromosome 14. ... in Nature 2003 (PubMed)
    Show all 2 references for 1533189

  4. Human Polyclonal Presenilin 1 Primary Antibody for IHC (p), WB - ABIN318924 : Weihofen, Martoglio: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. in Trends in cell biology 2003 (PubMed)
    Show all 2 references for 318924

  5. Human Monoclonal Presenilin 1 Primary Antibody for ELISA, ICC - ABIN268518 : Scarpi, Cirelli, Matrone, Castronovo, Rosini, Occhiato, Romano, Bartali, Clemente, Bottegoni, Cavalli, De Chiara, Bonini, Calissano, Palamara, Garaci, Torcia, Guarna, Cozzolino: Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity. in Cell death & disease 2012 (PubMed)

  6. Human Polyclonal Presenilin 1 Primary Antibody for FACS, IF - ABIN390169 : Nie, Li, Yan, Wang, Zhao, Guo, Yin: Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells. in Neurochemical research 2011 (PubMed)

More Antibodies against Presenilin 1 Interaction Partners

Zebrafish Presenilin 1 (PSEN1) interaction partners

  1. Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation

  2. We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish

  3. These results suggest that Psen2 (show PSEN2 Antibodies) plays a more prominent role in Notch (show NOTCH1 Antibodies) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (show PSEN2 Antibodies) can be ameliorated by Psen1 loss.

Human Presenilin 1 (PSEN1) interaction partners

  1. proapoptotic signaling pathways c-Jun NH2-terminal kinase (show MAPK8 Antibodies) and p38 mitogen-activated protein kinase (show MAPK14 Antibodies) maintained PSEN1-mediated negative regulation in K239N but not in E120G-bearing cells

  2. increased mitochondrial calcium due to the gain-of-function enhancement of IP3R (show ITPR1 Antibodies) channels in the cells expressing PS1-M146L leads to the opening of permeability transition pore in high conductance state.

  3. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein (show APP Antibodies), Presenilin 1, and Presenilin 2 (show PSEN2 Antibodies) as a cause of autosomal dominant AD

  4. The authors now show that the very little Abeta (show APP Antibodies) generated by PS1 L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  5. APP (show APP Antibodies) + PS1 double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP (show APP Antibodies) rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP (show APP Antibodies) + PS1 rats showed brain pathology as well as reduced memory retention compared to the APP (show APP Antibodies) and the ...

  6. gamma-Secretase is a multimeric membrane protease involved in processing of the amyloid precursor protein (show APP Antibodies) with high clinical relevance as mutations in its catalytic subunit (Presenilin) cause early-onset Alzheimer's disease

  7. Using purified PSEN1/Aph1A (show APH1A Antibodies) gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP (show APP Antibodies); present a unifying model for how PSEN or APP (show APP Antibodies) mutations enhance amyloidogenic Abeta (show APP Antibodies) production, suggests that environmental factors may increase Alzheimer's Disease risk.

  8. Findings do not provide significant support for presenilin 1 (PSEN1) E318G as a risk factor for Alzheimer's disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.

  9. Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b (show aph1b Antibodies)), presenilin 2 (PS2 (show PSEN2 Antibodies))/Aph1aL, PS2 (show PSEN2 Antibodies)/Aph1aS and PS2 (show PSEN2 Antibodies)/anterior pharynx defective 1 homolog B (Aph1b (show aph1b Antibodies)) gamma-secretase produced amyloid beta peptide (Abeta (show APP Antibodies)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  10. PSEN1 mutations are associated with specific AD phenotype.

Mouse (Murine) Presenilin 1 (PSEN1) interaction partners

  1. Study shows that the binding of HSF-1 (show HSF1 Antibodies), Cdx1 (show CDX1 Antibodies), Ets-1 (show ETS1 Antibodies) and Sp1 (show SP1 Antibodies) to Presenilin 1 promoter and that of Nkx2.2 (show Nkx2-2 Antibodies), HFH-2 (show FOXD3 Antibodies), Cdx1 (show CDX1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) to Presenilin 2 (show PSEN2 Antibodies) promoter regulate their differential expression during brain development.

  2. conclusion that the PSEN1 mutations are extreme examples of the previously proposed ''dysfunction'' of gamma-secretase that characterizes familial Alzheimer's disease

  3. PS1 expression is triggered by glutamate (show GRIN1 Antibodies) through p38alpha (show MAPK14 Antibodies), contributing to the excitotoxic stimulus of EW

  4. amino acid sensing of mechanistic target of rapamycin (show FRAP1 Antibodies) complex 1 (mTORC1) is dysregulated in cells deficient in presenilin.

  5. the G206D mutation reduced presenilin-1-presenilin enhancer 2 (show PSENEN Antibodies) interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis

  6. This study deals with the effect of attenuated endoproteolysis of PS1 on store-operated calcium (SOC (show UBXN11 Antibodies)) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2 (show PDCD6 Antibodies)

  7. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 (show PDCD6 Antibodies) during cerebral cortical development

  8. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP (show APP Antibodies)/PS1 mice

  9. PS1 deficiency depletes vATPase (show ATP6V1H Antibodies), impairing lysosomal acidification and calcium homeostasis.

  10. Abeta (show APP Antibodies) oligomers in the cerebrospinal fluid (CSF (show CSF2 Antibodies)) further promoted the expression of APH-1alpha (show APH1A Antibodies)/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP Antibodies) and Abeta (show APP Antibodies) deposition during AD progression

Pig (Porcine) Presenilin 1 (PSEN1) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 Antibodies) and PSEN1 genes via a STAT3 (show STAT3 Antibodies)-dependent pathway

Cow (Bovine) Presenilin 1 (PSEN1) interaction partners

  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (show FLT1 Antibodies)

Presenilin 1 (PSEN1) Antigen Profile

Antigen Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alternative names and synonyms associated with Presenilin 1 (PSEN1)

  • presenilin 1 (psen1) antibody
  • presenilin 1 (PSEN1) antibody
  • presenilin 1 (Psen1) antibody
  • AD3 antibody
  • Ad3h antibody
  • FAD antibody
  • pre1 antibody
  • PS-1 antibody
  • PS1 antibody
  • psen antibody
  • S182 antibody
  • X-PS-alpha antibody
  • X-PS-beta antibody
  • zf-PS1 antibody
  • zfPS1 antibody

Protein level used designations for anti-Presenilin 1 (PSEN1) Antibodies

PS-1 , presenilin-1 , presenilin 1 (Alzheimer disease 3) , presenilin-1 isoform I-463 , presenilin-1 isoform I-467 , presenilin 1 , presenilin-1-like , PS-alpha , presenilin alpha , presenilin-alpha

30221 Danio rerio
394924 Xenopus (Silurana) tropicalis
739740 Pan troglodytes
100173083 Pongo abelii
696274 Macaca mulatta
100401034 Callithrix jacchus
100586383 Nomascus leucogenys
5663 Homo sapiens
19164 Mus musculus
29192 Rattus norvegicus
373977 Gallus gallus
403408 Canis lupus familiaris
780411 Sus scrofa
282705 Bos taurus
100008886 Oryctolagus cuniculus
399258 Xenopus laevis
100728153 Cavia porcellus
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