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Browse our anti-Presenilin 1 (PSEN1) Antibodies

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anti-Presenilin 1 Antibodies (PSEN1)
On are 224 Presenilin 1 (PSEN1) Antibodies from 28 different suppliers available. Additionally we are shipping Presenilin 1 Kits (31) and Presenilin 1 Proteins (12) and many more products for this protein. A total of 284 Presenilin 1 products are currently listed.
AD3, Ad3h, FAD, pre1, PS-1, PS1, psen, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1
list all antibodies Gene Name GeneID UniProt
PSEN1 5663 P49768
PSEN1 19164 P49769
PSEN1 29192 P97887

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anti-Human Presenilin 1 Antibodies:

anti-Mouse (Murine) Presenilin 1 Antibodies:

anti-Rat (Rattus) Presenilin 1 Antibodies:

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Top referenced anti-Presenilin 1 Antibodies

  1. Human Polyclonal Presenilin 1 Primary Antibody for EIA, IHC (p) - ABIN358721 : Marambaud, Wen, Dutt, Shioi, Takashima, Siman, Robakis: A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. in Cell 2003 (PubMed)
    Show all 5 references for ABIN358721

  2. Human Polyclonal Presenilin 1 Primary Antibody for EIA, IHC (p) - ABIN500539 : Weihofen, Martoglio: Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides. in Trends in cell biology 2003 (PubMed)
    Show all 4 references for ABIN500539

  3. Human Polyclonal Presenilin 1 Primary Antibody for IHC, ELISA - ABIN1533189 : Sherrington, Rogaev, Liang, Rogaeva, Levesque, Ikeda, Chi, Lin, Li, Holman, Tsuda, Mar, Foncin, Bruni, Montesi, Sorbi, Rainero, Pinessi, Nee, Chumakov, Pollen, Brookes, Sanseau, Polinsky, Wasco et al.: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. ... in Nature 1995 (PubMed)
    Show all 2 references for ABIN1533189

  4. Human Polyclonal Presenilin 1 Primary Antibody for EIA, WB - ABIN493376 : Hansson, Popescu, Laudon, Cedazo-Minguez, Popescu, Winblad, Ankarcrona: Caspase cleaved presenilin-1 is part of active gamma-secretase complexes. in Journal of neurochemistry 2006 (PubMed)
    Show all 2 references for ABIN493376

  5. Human Polyclonal Presenilin 1 Primary Antibody for IHC, ELISA - ABIN1532166 : Heilig, Eckenberg, Petit, Fonknechten, Da Silva, Cattolico, Levy, Barbe, de Berardinis, Ureta-Vidal, Pelletier, Vico, Anthouard, Rowen, Madan, Qin, Sun, Du, Pepin, Artiguenave, Robert, Cruaud, Brüls et al.: The DNA sequence and analysis of human chromosome 14. ... in Nature 2003 (PubMed)
    Show all 2 references for ABIN1532166

  6. Human Polyclonal Presenilin 1 Primary Antibody for IHC (p), WB - ABIN318924 : Periz, Fortini: Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. in Journal of neuroscience research 2004 (PubMed)
    Show all 2 references for ABIN318924

  7. Human Polyclonal Presenilin 1 Primary Antibody for FACS, IF - ABIN390169 : Nie, Li, Yan, Wang, Zhao, Guo, Yin: Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells. in Neurochemical research 2011 (PubMed)

More Antibodies against Presenilin 1 Interaction Partners

Zebrafish Presenilin 1 (PSEN1) interaction partners

  1. We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish

  2. These results suggest that Psen2 (show PSEN2 Antibodies) plays a more prominent role in Notch (show NOTCH1 Antibodies) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (show PSEN2 Antibodies) can be ameliorated by Psen1 loss.

Human Presenilin 1 (PSEN1) interaction partners

  1. These findings identify Syt1 (show SYT1 Antibodies) as a novel Ca(2 (show CA2 Antibodies)+)-sensitive PS1 modulator that could regulate synaptic ABETA (show APP Antibodies), opening avenues for novel and selective synapse targeting therapeutic strategies.

  2. Expression of mutated presenilin 1 (PS1M146V) in astrocytes alters vesicle dynamics and reduces evoked secretion of the signaling molecule ANP (show NPPA Antibodies); both may contribute to the development of Alzheimer disease

  3. PS1(exon8) interacts with nicastrin (show NCSTN Antibodies), participating in the gamma-secretase complex formation.

  4. Preclinical cognitive decline was evident in PSEN1 E280A mutation carriers with autosomal dominant Alzheimer's Disease.

  5. most of familial that most of familial Alzheimer's disease-connected mutations in PS1 are loss-of-fu (show UBXN11 Antibodies)nction-connected mutations in PS1 are loss-of-function

  6. The chemical properties of PSEN1 variants were computed and correlated against clinical age of symptom onset. Loss of stability and hydrophobicity and gain of polarity relate to disease onset. Mutants impair the membrane structure of PSEN1.

  7. A mutation (c.488A>G, p.His163Arg) of PSEN1 gene was found in a Chinese family affected with early-onset familial Alzheimer's disease (EOFAD).

  8. This report showed that a novel PSEN1 mutation (P267A) and strong evidence for its pathogenicity.

  9. the PS1 Thr147Ile substitution in Alzheimer's disease expands the clinical phenotype to include expressive aphasia and very early onset of dementia

  10. This study identified variants in PSEN1 across a range of phenotypes (Alzheimer's Disease , Alzheimer's Disease and cerebrovascular disease,frontotemporal dementia and progressive supranuclear palsy.

Mouse (Murine) Presenilin 1 (PSEN1) interaction partners

  1. the G206D mutation reduced presenilin-1-presenilin enhancer 2 (show PSENEN Antibodies) interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis

  2. This study deals with the effect of attenuated endoproteolysis of PS1 on store-operated calcium (SOC (show UBXN11 Antibodies)) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2 (show PDCD6 Antibodies)

  3. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 (show PDCD6 Antibodies) during cerebral cortical development

  4. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP (show APP Antibodies)/PS1 mice

  5. PS1 deficiency depletes vATPase (show ATP6V1H Antibodies), impairing lysosomal acidification and calcium homeostasis.

  6. Abeta (show APP Antibodies) oligomers in the cerebrospinal fluid (CSF (show CSF2 Antibodies)) further promoted the expression of APH-1alpha (show APH1A Antibodies)/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP Antibodies) and Abeta (show APP Antibodies) deposition during AD progression

  7. This study presents novel evidence for the differential expression of PS proteins in a nongenetic model for aging, resulting in an overall increase of the PS2 (show PDCD6 Antibodies) to PS1 ratio.

  8. Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.

  9. SLC2A13 (show SLC2A13 Antibodies) is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch (show NOTCH1 Antibodies) cleavage.

  10. PS1 may affect neuroprotection and Alzheimer disease by controlling survival signaling of neuronal EGFR (show EGFR Antibodies).

Cow (Bovine) Presenilin 1 (PSEN1) interaction partners

  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (show FLT1 Antibodies)

Presenilin 1 (PSEN1) Antigen Profile

Antigen Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alternative names and synonyms associated with Presenilin 1 (PSEN1)

  • presenilin 1 (psen1) antibody
  • presenilin 1 (PSEN1) antibody
  • presenilin 1 (Psen1) antibody
  • AD3 antibody
  • Ad3h antibody
  • FAD antibody
  • pre1 antibody
  • PS-1 antibody
  • PS1 antibody
  • psen antibody
  • S182 antibody
  • X-PS-alpha antibody
  • X-PS-beta antibody
  • zf-PS1 antibody
  • zfPS1 antibody

Protein level used designations for anti-Presenilin 1 (PSEN1) Antibodies

PS-1 , presenilin-1 , presenilin 1 (Alzheimer disease 3) , presenilin-1 isoform I-463 , presenilin-1 isoform I-467 , presenilin 1 , presenilin-1-like , PS-alpha , presenilin alpha , presenilin-alpha

30221 Danio rerio
394924 Xenopus (Silurana) tropicalis
739740 Pan troglodytes
100173083 Pongo abelii
696274 Macaca mulatta
100401034 Callithrix jacchus
100586383 Nomascus leucogenys
5663 Homo sapiens
19164 Mus musculus
29192 Rattus norvegicus
373977 Gallus gallus
403408 Canis lupus familiaris
780411 Sus scrofa
282705 Bos taurus
100008886 Oryctolagus cuniculus
399258 Xenopus laevis
100728153 Cavia porcellus
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