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Presenilin 1 antibody (Middle Region)

PSEN1 Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit WB, IHC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2787886
  • Target See all Presenilin 1 (PSEN1) Antibodies
    Presenilin 1 (PSEN1)
    Binding Specificity
    • 31
    • 15
    • 15
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 122
    • 100
    • 65
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit
    Host
    • 110
    • 36
    • 2
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 144
    • 8
    Polyclonal
    Conjugate
    • 48
    • 12
    • 12
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    This Presenilin 1 antibody is un-conjugated
    Application
    • 121
    • 56
    • 54
    • 52
    • 52
    • 18
    • 15
    • 13
    • 10
    • 8
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Sequence
    EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
    Predicted Reactivity
    Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 85%
    Characteristics
    This is a rabbit polyclonal antibody against PSEN1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PSEN1
    Top Product
    Discover our top product PSEN1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 467 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Presenilin 1 (PSEN1)
    Alternative Name
    PSEN1 (PSEN1 Products)
    Synonyms
    pre1 antibody, psen antibody, zfPS1 antibody, zf-PS1 antibody, ad3 antibody, fad antibody, ps1 antibody, s182 antibody, X-PS-beta antibody, X-PS-alpha antibody, AD3 antibody, FAD antibody, PS-1 antibody, PS1 antibody, S182 antibody, Ad3h antibody, presenilin 1 antibody, presenilin 1 L homeolog antibody, psen1 antibody, PSEN1 antibody, Psen1 antibody, psen1.L antibody
    Background
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
    Alias Symbols: AD3, FAD, PS1, S182, PS-1
    Protein Interaction Partner: UBC, TRAF6, TGFBR1, ERLIN2, PSMB1, PSMA5, ETFA, TDP2, PSEN2, PSEN1, APH1B, PSENEN, APH1A, NCSTN, ITSN2, PDCD4, KANK2, EPB41L3, CDC37, TUBA1B, AP1M2, UMPS, PRDX2, ST13, SCN1A, RHEB, RAD23A, RAB3A, OXCT1, NOS3, NDUFS8, HMGB1, GCDH, GAPDH, FGF13, ENSA, DTNA,
    Protein Size: 467
    Molecular Weight
    53 kDa
    Gene ID
    5663
    NCBI Accession
    NM_000021, NP_000012
    UniProt
    P49768
    Pathways
    Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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