Browse our Presenilin 1 (PSEN1) ELISA Kits

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Presenilin 1 ELISA Kits (PSEN1)
On www.antibodies-online.com are 33 Presenilin 1 (PSEN1) ELISA Kits from 13 different suppliers available. Additionally we are shipping Presenilin 1 Antibodies (269) and Presenilin 1 Proteins (12) and many more products for this protein. A total of 331 Presenilin 1 products are currently listed.
Synonyms:
AD3, Ad3h, FAD, pre1, PS-1, PS1, psen, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1
list all ELISA KIts Gene Name GeneID UniProt
PSEN1 5663 P49768
PSEN1 19164 P49769
PSEN1 29192 P97887

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Top referenced Presenilin 1 ELISA Kits

  1. Human Presenilin 1 ELISA Kit for Sandwich ELISA - ABIN417919 : Paulasir, Kaoutzanis, Welch, Vandewarker, Krapohl, Lampman, Franz, Cleary: Nonsteroidal Anti-inflammatory Drugs: Do They Increase the Risk of Anastomotic Leaks Following Colorectal Operations? in Diseases of the colon and rectum 2015 (PubMed)

  2. Human Presenilin 1 ELISA Kit for Sandwich ELISA - ABIN1110865 : Ankarcrona, Hultenby: Presenilin-1 is located in rat mitochondria. in Biochemical and biophysical research communications 2002 (PubMed)

More ELISA Kits for Presenilin 1 Interaction Partners

Zebrafish Presenilin 1 (PSEN1) interaction partners

  1. Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation

  2. We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish

  3. These results suggest that Psen2 (show PSEN2 ELISA Kits) plays a more prominent role in Notch (show NOTCH1 ELISA Kits) signalling and embryo development in zebrafish than in mammals, and that the effect of reduced Psen2 (show PSEN2 ELISA Kits) can be ameliorated by Psen1 loss.

Human Presenilin 1 (PSEN1) interaction partners

  1. proapoptotic signaling pathways c-Jun NH2-terminal kinase (show MAPK8 ELISA Kits) and p38 mitogen-activated protein kinase (show MAPK14 ELISA Kits) maintained PSEN1-mediated negative regulation in K239N but not in E120G-bearing cells

  2. increased mitochondrial calcium due to the gain-of-function enhancement of IP3R (show ITPR1 ELISA Kits) channels in the cells expressing PS1-M146L leads to the opening of permeability transition pore in high conductance state.

  3. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein (show APP ELISA Kits), Presenilin 1, and Presenilin 2 (show PSEN2 ELISA Kits) as a cause of autosomal dominant AD

  4. The authors now show that the very little Abeta (show APP ELISA Kits) generated by PS1 L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  5. APP (show APP ELISA Kits) + PS1 double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP (show APP ELISA Kits) rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP (show APP ELISA Kits) + PS1 rats showed brain pathology as well as reduced memory retention compared to the APP (show APP ELISA Kits) and the ...

  6. gamma-Secretase is a multimeric membrane protease involved in processing of the amyloid precursor protein (show APP ELISA Kits) with high clinical relevance as mutations in its catalytic subunit (Presenilin) cause early-onset Alzheimer's disease

  7. Using purified PSEN1/Aph1A (show APH1A ELISA Kits) gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP (show APP ELISA Kits); present a unifying model for how PSEN or APP (show APP ELISA Kits) mutations enhance amyloidogenic Abeta (show APP ELISA Kits) production, suggests that environmental factors may increase Alzheimer's Disease risk.

  8. Findings do not provide significant support for presenilin 1 (PSEN1) E318G as a risk factor for Alzheimer's disease (AD) in apolipoprotein E4 (APOEepsilon4) carriers.

  9. Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b (show aph1b ELISA Kits)), presenilin 2 (PS2 (show PSEN2 ELISA Kits))/Aph1aL, PS2 (show PSEN2 ELISA Kits)/Aph1aS and PS2 (show PSEN2 ELISA Kits)/anterior pharynx defective 1 homolog B (Aph1b (show aph1b ELISA Kits)) gamma-secretase produced amyloid beta peptide (Abeta (show APP ELISA Kits)) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  10. PSEN1 mutations are associated with specific AD phenotype.

Mouse (Murine) Presenilin 1 (PSEN1) interaction partners

  1. Study shows that the binding of HSF-1 (show HSF1 ELISA Kits), Cdx1 (show CDX1 ELISA Kits), Ets-1 (show ETS1 ELISA Kits) and Sp1 (show SP1 ELISA Kits) to Presenilin 1 promoter and that of Nkx2.2 (show Nkx2-2 ELISA Kits), HFH-2 (show FOXD3 ELISA Kits), Cdx1 (show CDX1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) to Presenilin 2 (show PSEN2 ELISA Kits) promoter regulate their differential expression during brain development.

  2. conclusion that the PSEN1 mutations are extreme examples of the previously proposed ''dysfunction'' of gamma-secretase that characterizes familial Alzheimer's disease

  3. PS1 expression is triggered by glutamate (show GRIN1 ELISA Kits) through p38alpha (show MAPK14 ELISA Kits), contributing to the excitotoxic stimulus of EW

  4. amino acid sensing of mechanistic target of rapamycin (show FRAP1 ELISA Kits) complex 1 (mTORC1) is dysregulated in cells deficient in presenilin.

  5. the G206D mutation reduced presenilin-1-presenilin enhancer 2 (show PSENEN ELISA Kits) interaction, but did not abolish gamma-secretase formation and presenilin-1 endoproteolysis

  6. This study deals with the effect of attenuated endoproteolysis of PS1 on store-operated calcium (SOC (show UBXN11 ELISA Kits)) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2 (show PDCD6 ELISA Kits)

  7. Results showed that epigenetic mechanisms play a pivotal role in transcriptional regulation of PS1 and PS2 (show PDCD6 ELISA Kits) during cerebral cortical development

  8. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP (show APP ELISA Kits)/PS1 mice

  9. PS1 deficiency depletes vATPase (show ATP6V1H ELISA Kits), impairing lysosomal acidification and calcium homeostasis.

  10. Abeta (show APP ELISA Kits) oligomers in the cerebrospinal fluid (CSF (show CSF2 ELISA Kits)) further promoted the expression of APH-1alpha (show APH1A ELISA Kits)/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP (show APP ELISA Kits) and Abeta (show APP ELISA Kits) deposition during AD progression

Pig (Porcine) Presenilin 1 (PSEN1) interaction partners

  1. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (show CCND2 ELISA Kits) and PSEN1 genes via a STAT3 (show STAT3 ELISA Kits)-dependent pathway

Cow (Bovine) Presenilin 1 (PSEN1) interaction partners

  1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1 (show FLT1 ELISA Kits)

Presenilin 1 (PSEN1) Antigen Profile

Antigen Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Alternative names and synonyms associated with Presenilin 1 (PSEN1)

  • presenilin 1 (psen1) Elisa Kit
  • presenilin 1 (PSEN1) Elisa Kit
  • presenilin 1 (Psen1) Elisa Kit
  • AD3 Elisa Kit
  • Ad3h Elisa Kit
  • FAD Elisa Kit
  • pre1 Elisa Kit
  • PS-1 Elisa Kit
  • PS1 Elisa Kit
  • psen Elisa Kit
  • S182 Elisa Kit
  • X-PS-alpha Elisa Kit
  • X-PS-beta Elisa Kit
  • zf-PS1 Elisa Kit
  • zfPS1 Elisa Kit

Protein level used designations for Presenilin 1 (PSEN1) ELISA Kits

PS-1 , presenilin-1 , presenilin 1 (Alzheimer disease 3) , presenilin-1 isoform I-463 , presenilin-1 isoform I-467 , presenilin 1 , presenilin-1-like , PS-alpha , presenilin alpha , presenilin-alpha

GENE ID SPECIES
30221 Danio rerio
394924 Xenopus (Silurana) tropicalis
739740 Pan troglodytes
100173083 Pongo abelii
696274 Macaca mulatta
100401034 Callithrix jacchus
100586383 Nomascus leucogenys
5663 Homo sapiens
19164 Mus musculus
29192 Rattus norvegicus
373977 Gallus gallus
403408 Canis lupus familiaris
780411 Sus scrofa
282705 Bos taurus
100008886 Oryctolagus cuniculus
399258 Xenopus laevis
100728153 Cavia porcellus
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