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Browse our Presenilin Enhancer 2 Homolog (C. Elegans) Proteins (PSENEN)

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Presenilin Enhancer 2 Homolog (C. Elegans) Proteins (PSENEN)
On are 4 Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Proteins from 3 different suppliers available. Additionally we are shipping Presenilin Enhancer 2 Homolog (C. Elegans) Antibodies (60) and Presenilin Enhancer 2 Homolog (C. Elegans) Kits (4) and many more products for this protein. A total of 76 Presenilin Enhancer 2 Homolog (C. Elegans) products are currently listed.
1700023M09Rik, ACYPI006208, anon-AE003800.1, CG33198, Dmel\\CG33198, dPen-2, MSTP064, PEN-2, PEN2, Psenen, RGD1312037, T5E8.110, T5E8_110
list all proteins Gene Name GeneID UniProt
PSENEN 55851 Q9NZ42

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Presenilin Enhancer 2 Homolog (C. Elegans) Proteins (PSENEN) by Origin

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More Proteins for Presenilin Enhancer 2 Homolog (C. Elegans) Interaction Partners

Fruit Fly (Drosophila melanogaster) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex.

  2. presenilin, nicastrin (show NCSTN Proteins), APH-1, and PEN-2, are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes

Arabidopsis thaliana Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. All gamma-secretase subunits: PS1/PS2, APH-1, PEN-2, and NCT colocalize and interact with each other in Arabidopsis thaliana protoplasts. [AtPEN-2]

Human Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. TRPC6 (show TRPC6 Proteins) specifically interacts with APP (show APP Proteins) leading to inhibition of its cleavage by gamma-secretase and reduction in Abeta (show APP Proteins) production.

  2. secondary mutations in presenilin 1 (show PSEN1 Proteins) alone activated the gamma-secretase activity.

  3. Data indicate that familial Alzheimer's disease (FAD (show BRCA2 Proteins)) and control brain samples had similar overall gamma-secretase activity levels, and therefore, loss of overall (endopeptidase) gamma-secretase function cannot be an essential part of the pathogenic mechanism.

  4. We for the first time identify PEN-2 as the causative gene of familial comedones.

  5. The first hydrophobic domain of Pen-2 forms a structure similar to a reentrant loop while the second hydrophobic domain spans the lipid bilayer.

  6. shedding of BCMA (show TNFRSF17 Proteins) by gamma-secretase controls plasma cells in the bone marrow and yields a potential biomarker for B-cell involvement in human autoimmune diseases

  7. Tumor necrosis factor-alpha (show TNF Proteins) and interleukin-10 (show IL10 Proteins) levels were elevated in acne inversa patients with nicastrin (show NCSTN Proteins) or presenilin enhancer mutation.

  8. SLC2A13 is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch (show NOTCH1 Proteins) cleavage.

  9. A complete inhibition of PS1 (show PSEN1 Proteins)-induced apoptosis was achieved by knockdown of PS1 (show PSEN1 Proteins)-associated protein (PSAP (show PSAP Proteins)), a mitochondrial proapoptotic protein that forms a complex with Bax (show BAX Proteins) upon induction of apoptosis, in the presence of gamma-secretase inhibitor.

  10. analysis of how the conformation of presenilin, Pen-2, Aph-1, and nicastrin (show NCSTN Proteins) affect the function and mechanism of gamma-secretase

Mouse (Murine) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. the G206D mutation reduced presenilin-1 (show PSEN1 Proteins)-presenilin enhancer 2 interaction, but did not abolish gamma-secretase formation and presenilin-1 (show PSEN1 Proteins) endoproteolysis

  2. Data show that the expression level of presenilin enhancer-2 (Pen-2) is relatively high in central nervous system at the early stages of postnatal development, but declines, gradually in adult mice.

  3. rather than solely being a catalyst for gamma-secretase endoproteolysis, Pen-2 may also stabilize the complex prior to PS1 (show PSEN1 Proteins) endoproteolysis, allowing time for full assembly and proper trafficking.

  4. Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis

  5. Nct (show NCSTN Proteins) has a critical role in the stability and proper intracellular trafficking of other components of the PS1 (show PSEN1 Proteins)/ gamma-secretase complex but not in maintaining the association of PEN-2, APH-1, and full-length PS1 (show PSEN1 Proteins)

Cow (Bovine) Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) interaction partners

  1. The PSENEN gene is down-regulated in bovine intramuscular fibroblast cells during differentiation into adipocytes.

Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN) Protein Profile

Protein Summary

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Alternative names and synonyms associated with Presenilin Enhancer 2 Homolog (C. Elegans) (PSENEN)

  • presenilin enhancer (pen-2)
  • hypothetical protein (AT5G09310)
  • presenilin enhancer 2 (PEN2)
  • presenilin enhancer 2 (Psenen)
  • presenilin enhancer 2 homolog (C. elegans) (PSENEN)
  • presenilin enhancer 2 homolog (C. elegans) (Psenen)
  • Protein PEN-2 (pen-2)
  • 1700023M09Rik protein
  • ACYPI006208 protein
  • anon-AE003800.1 protein
  • CG33198 protein
  • Dmel\\CG33198 protein
  • dPen-2 protein
  • MSTP064 protein
  • PEN-2 protein
  • PEN2 protein
  • Psenen protein
  • RGD1312037 protein
  • T5E8.110 protein
  • T5E8_110 protein

Protein level used designations for PSENEN

CG33198-PA , pen-2-PA , presenilin enhancer 2 , gamma-secretase subunit PEN-2 , hematopoietic stem/progenitor cells protein MDS033 , presenilin enhancer protein 2 , LRRGT00140 mRNA , liver regeneration-related protein LRRGT00140

251430 Drosophila melanogaster
830790 Arabidopsis thaliana
5726417 Chlamydomonas reinhardtii
100165248 Acyrthosiphon pisum
55851 Homo sapiens
66340 Mus musculus
493993 Bos taurus
292788 Rattus norvegicus
176565 Caenorhabditis elegans
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