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Browse our anti-Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antibodies

Full name:
anti-Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies (NR1I2)
On www.antibodies-online.com are 149 Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antibodies from 20 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 2 Kits (17) and Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (12) and many more products for this protein. A total of 189 Nuclear Receptor Subfamily 1, Group I, Member 2 products are currently listed.
Synonyms:
BXR, mPXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR
list all antibodies Gene Name GeneID UniProt
NR1I2 8856 O75469
NR1I2 18171 O54915
NR1I2 84385 Q9R1A7

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Top referenced anti-Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies

  1. Human Polyclonal NR1I2 Primary Antibody for IHC, WB - ABIN2774988 : Hesselink, van Schaik, Nauta, van Gelder: A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. in Pharmacogenomics 2008 (PubMed)
    Show all 3 references for ABIN2774988

  2. Human Polyclonal NR1I2 Primary Antibody for ELISA, WB - ABIN449909 : Thakur, Arthanari, Yang, Pan, Fan, Breger, Frueh, Gulshan, Li, Mylonakis, Struhl, Moye-Rowley, Cormack, Wagner, Näär: A nuclear receptor-like pathway regulating multidrug resistance in fungi. in Nature 2008 (PubMed)

  3. Human Polyclonal NR1I2 Primary Antibody for IHC, ELISA - ABIN1584988 : Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013 (PubMed)

  4. Human Polyclonal NR1I2 Primary Antibody for ELISA, WB - ABIN1452177 : Zhang, Kuehl, Green, Touchman, Watkins, Daly, Hall, Maurel, Relling, Brimer, Yasuda, Wrighton, Hancock, Kim, Strom, Thummel, Russell, Hudson, Schuetz, Boguski: The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. in Pharmacogenetics 2001 (PubMed)

  5. Human Polyclonal NR1I2 Primary Antibody for EIA, WB - ABIN453773 : Lehmann, McKee, Watson, Willson, Moore, Kliewer: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. in The Journal of clinical investigation 1998 (PubMed)

  6. Cow (Bovine) Polyclonal NR1I2 Primary Antibody for WB - ABIN2781173 : Dring, Goulding, Trimble, Keegan, Ryan, Brophy, Smyth, Keeling, ODonoghue, OSullivan, OMorain, Mahmud, Wikström, Kelleher, McManus: The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. in Gastroenterology 2006 (PubMed)

More Antibodies against Nuclear Receptor Subfamily 1, Group I, Member 2 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. result suggests that in Indonesian patients with tuberculosis, the risk of having antituberculosis drug-induced liver injury was associated with TT genotype of the PXR gene

  2. EPAS-1 (show EPAS1 Antibodies) and PXR may cooperatively participate in development and especially MDR process of stomach cancer

  3. decreases of CES and CYP3A4 (show CYP3A4 Antibodies) expression and enzymatic activities induced by Fluoxetine are through decreasing PXR and increasing DEC1 (show BHLHE40 Antibodies) in HepG2 cells

  4. Reported is the distribution of allelic and genotypic frequencies of IL1A (show IL1A Antibodies), IL4 (show IL4 Antibodies), NFKB1 (show NFKB1 Antibodies) and PAR1 (show MARK2 Antibodies) variants in Native American, African, and European populations of Brazil and their association with predisposition to cancer.

  5. We found that ARRDC3 is required for ALIX (show PDCD6IP Antibodies) ubiquitination induced by activation of PAR1 (show MARK2 Antibodies)

  6. SUMOylation at specific sites on PXR protein are involved in enhancement of transcription function of this receptor.

  7. hPXR is regulated through its phosphorylation at threonine-408 by PKC, CHIP/chaperone-dependent stability check, and autophagic degradation pathway.

  8. we have identified novel PXR dependent pathways in human de novo lipogenesis, which may participate in hepatic steatosis and pathogenesis of steatohepatitis

  9. Role of NR1I2 polymorphisms in head and neck squamous cell carcinoma

  10. Our results revealed that PXR could be a determinant of stable warfarin doses.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. The regulatory effect of IFN-gamma (show IFNG Antibodies) on CYP3A29 expression is mediated via PXR.

  2. Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.

  3. In conclusion, PXR and FXR (show NR1H4 Antibodies) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Antibodies) transactivation at in vivo expression levels.

  4. the PXR gene revealed multiple splice variants in the ligand-binding domain

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage

  2. PXR activation stimulates EGF (show EGF Antibodies)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Antibodies) from accelerating cell-cycle progression.

  3. The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.

  4. modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.

  5. results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.

  6. Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.

  7. a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4 (show TLR4 Antibodies).

  8. Role of pregnane X receptor in obesity and glucose homeostasis

  9. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha (show PPARA Antibodies) is enhanced by PXR co-activation despite the fact that PXR activation alone does not cause the cell proliferation in mouse livers.

  10. Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics.

Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antigen Profile

Antigen Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2)

  • nuclear receptor subfamily 1, group I, member 2 (NR1I2) antibody
  • nuclear receptor subfamily 1, group I, member 2 (Nr1i2) antibody
  • pregnane x receptor (PXR) antibody
  • BXR antibody
  • mPXR antibody
  • ONR1 antibody
  • PAR antibody
  • PAR1 antibody
  • PAR2 antibody
  • PARq antibody
  • PRR antibody
  • PXR antibody
  • PXR.1 antibody
  • PXR.2 antibody
  • PXR1 antibody
  • SAR antibody
  • SXR antibody

Protein level used designations for NR1I2

nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor , Pregnane X receptor , nuclear receptor subfamily 1, group 1, member 2 , pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

GENE ID SPECIES
8856 Homo sapiens
403482 Canis lupus familiaris
397228 Sus scrofa
493713 Bos taurus
18171 Mus musculus
84385 Rattus norvegicus
574226 Macaca mulatta
100008739 Oryctolagus cuniculus
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