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Browse our anti-Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antibodies

Full name:
anti-Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies (NR1I2)
On www.antibodies-online.com are 124 Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antibodies from 20 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 2 Kits (17) and Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (12) and many more products for this protein. A total of 164 Nuclear Receptor Subfamily 1, Group I, Member 2 products are currently listed.
Synonyms:
BXR, mPXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR
list all antibodies Gene Name GeneID UniProt
NR1I2 8856 O75469
NR1I2 18171 O54915
NR1I2 84385 Q9R1A7

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All available anti-Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies

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Top referenced anti-Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies

  1. Human Polyclonal NR1I2 Primary Antibody for IHC, WB - ABIN2774988 : Hesselink, van Schaik, Nauta, van Gelder: A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. in Pharmacogenomics 2008 (PubMed)
    Show all 3 references for ABIN2774988

  2. Human Polyclonal NR1I2 Primary Antibody for IHC, ELISA - ABIN1584988 : Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013 (PubMed)

  3. Human Polyclonal NR1I2 Primary Antibody for IF (p), IHC (p) - ABIN679598 : Sehirli, Cetinel, Ozkan, Selman, Tetik, Yuksel, Dulger: St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2015 (PubMed)

  4. Human Polyclonal NR1I2 Primary Antibody for ELISA, WB - ABIN1452177 : Zhang, Kuehl, Green, Touchman, Watkins, Daly, Hall, Maurel, Relling, Brimer, Yasuda, Wrighton, Hancock, Kim, Strom, Thummel, Russell, Hudson, Schuetz, Boguski: The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. in Pharmacogenetics 2001 (PubMed)

  5. Human Polyclonal NR1I2 Primary Antibody for WB - ABIN375099 : Thakur, Arthanari, Yang, Pan, Fan, Breger, Frueh, Gulshan, Li, Mylonakis, Struhl, Moye-Rowley, Cormack, Wagner, Näär: A nuclear receptor-like pathway regulating multidrug resistance in fungi. in Nature 2008 (PubMed)

  6. Human Polyclonal NR1I2 Primary Antibody for EIA, WB - ABIN453773 : Lehmann, McKee, Watson, Willson, Moore, Kliewer: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. in The Journal of clinical investigation 1998 (PubMed)

  7. Cow (Bovine) Polyclonal NR1I2 Primary Antibody for WB - ABIN2781173 : Dring, Goulding, Trimble, Keegan, Ryan, Brophy, Smyth, Keeling, ODonoghue, OSullivan, OMorain, Mahmud, Wikström, Kelleher, McManus: The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. in Gastroenterology 2006 (PubMed)

More Antibodies against Nuclear Receptor Subfamily 1, Group I, Member 2 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. We found that ARRDC3 is required for ALIX (show PDCD6IP Antibodies) ubiquitination induced by activation of PAR1 (show MARK2 Antibodies)

  2. SUMOylation at specific sites on PXR protein are involved in enhancement of transcription function of this receptor.

  3. hPXR is regulated through its phosphorylation at threonine-408 by PKC, CHIP/chaperone-dependent stability check, and autophagic degradation pathway.

  4. we have identified novel PXR dependent pathways in human de novo lipogenesis, which may participate in hepatic steatosis and pathogenesis of steatohepatitis

  5. Role of NR1I2 polymorphisms in head and neck squamous cell carcinoma

  6. Our results revealed that PXR could be a determinant of stable warfarin doses.

  7. Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were less sensitive to thrombocytopenia than those harboring other haplotypes

  8. Genotyping of CYP3A4 (show CYP3A4 Antibodies)/MDR1 (show TBC1D9 Antibodies)/NR1I2 polymorphisms may be helpful for better guiding tacrolimus dosing in CYP3A5 (show CYP3A5 Antibodies) nonexpressers.

  9. Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.

  10. PSC is characterized by disease-specific impairment of SULT2A1 (show SULT2A1 Antibodies) expression following PXR activation, a phenomenon which is not noted in PBC (show DLAT Antibodies), and may account for the impaired hepatoprotection in PSC.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. The regulatory effect of IFN-gamma (show IFNG Antibodies) on CYP3A29 expression is mediated via PXR.

  2. Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.

  3. In conclusion, PXR and FXR (show NR1H4 Antibodies) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Antibodies) transactivation at in vivo expression levels.

  4. the PXR gene revealed multiple splice variants in the ligand-binding domain

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. PXR activation stimulates EGF (show EGF Antibodies)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Antibodies) from accelerating cell-cycle progression.

  2. The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.

  3. modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.

  4. results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.

  5. Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.

  6. a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4 (show TLR4 Antibodies).

  7. Role of pregnane X receptor in obesity and glucose homeostasis

  8. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha (show PPARA Antibodies) is enhanced by PXR co-activation despite the fact that PXR activation alone does not cause the cell proliferation in mouse livers.

  9. Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics.

  10. Study reveals that alpha-tocopherol is a partial agonist of PXR and that PXR is necessary for Cyp3a induction by alpha-tocopherol in Pxr-null and PXR-humanized mice.

Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Antigen Profile

Antigen Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2)

  • nuclear receptor subfamily 1, group I, member 2 (NR1I2) antibody
  • nuclear receptor subfamily 1, group I, member 2 (Nr1i2) antibody
  • pregnane x receptor (PXR) antibody
  • BXR antibody
  • mPXR antibody
  • ONR1 antibody
  • PAR antibody
  • PAR1 antibody
  • PAR2 antibody
  • PARq antibody
  • PRR antibody
  • PXR antibody
  • PXR.1 antibody
  • PXR.2 antibody
  • PXR1 antibody
  • SAR antibody
  • SXR antibody

Protein level used designations for NR1I2

nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor , Pregnane X receptor , nuclear receptor subfamily 1, group 1, member 2 , pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

GENE ID SPECIES
8856 Homo sapiens
403482 Canis lupus familiaris
397228 Sus scrofa
493713 Bos taurus
18171 Mus musculus
84385 Rattus norvegicus
574226 Macaca mulatta
100008739 Oryctolagus cuniculus
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