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Human Polyclonal NR1I2 Primary Antibody for IHC, WB - ABIN2774988
Hesselink, van Schaik, Nauta, van Gelder: A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. in Pharmacogenomics 2008
Show all 3 Pubmed References
Human Polyclonal NR1I2 Primary Antibody for IF (p), IHC (p) - ABIN679598
Sehirli, Cetinel, Ozkan, Selman, Tetik, Yuksel, Dulger: St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins. in Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2015
Show all 2 Pubmed References
Human Polyclonal NR1I2 Primary Antibody for IHC, ELISA - ABIN1584988
Yau, Liu, Fairlie: Toward drugs for protease-activated receptor 2 (PAR2). in Journal of medicinal chemistry 2013
Human Polyclonal NR1I2 Primary Antibody for ELISA, WB - ABIN449909
Thakur, Arthanari, Yang, Pan, Fan, Breger, Frueh, Gulshan, Li, Mylonakis, Struhl, Moye-Rowley, Cormack, Wagner, Näär: A nuclear receptor-like pathway regulating multidrug resistance in fungi. in Nature 2008
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC Antibodies) coactivator.
This study revealed for the first time the involvement of NR1I2 in the pharmacogenetics of irinotecan and suggest that it may help to predict the toxicity of low-dose irinotecan.
In intrahepatic cholestasis of pregnancy, gene silencing of miR (show MLXIP Antibodies)-148a upregulated PXR expression which was inhibited by estradiol in liver cells. miR (show MLXIP Antibodies)-148a may be involved in the estrogen induction in ICP via PXR signaling. MRP3 (show ABCC3 Antibodies) may be involved.
this study shows that PXR augments Mycobacterium tuberculosis survival inside the host macrophages by promoting the foamy macrophage formation and abrogating phagolysosomal fusion, inflammation, and apoptosis
PXR is a potential biomarker for predicting outcome and activates MRP3 (show ABCC3 Antibodies) transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC (show CALR Antibodies).
This is the first time an association between NR1I2 polymorphism and time of progression to AIDS is reported and supports an apparent relationship between the gene in the immune response and identifies another genetic factor influencing AIDS progression.
MD simulations further revealed that the presence of small molecule at allosteric site disrupts the LBD dynamics and locks the LBD in a "tightly-contracted" conformation. The molecular details provided here could guide new structural studies to understand PXR activation and antagonism.
Extracellular granzyme K (show GZMK Antibodies) mediates endothelial activation through the cleavage of PAR-1 (show MARK2 Antibodies).
Pregnane X receptor interacts with liver X receptor to regulate expression of SMPDL3A in primary hepatocytes.
66034T/C polymorphism of the human pregnane X receptor (hPXR) is potential risk factor for drug-resistant epilepsy.
The regulatory effect of IFN-gamma (show IFNG Antibodies) on CYP3A29 expression is mediated via PXR.
Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.
In conclusion, PXR and FXR (show NR1H4 Antibodies) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Antibodies) transactivation at in vivo expression levels.
the PXR gene revealed multiple splice variants in the ligand-binding domain
Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands.
FGF21 (show FGF21 Antibodies)-PXR signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Antibodies) metabolic activity in Nonalcoholic fatty liver disease.
Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con (show KITLG Antibodies) A.
carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage
PXR activation stimulates EGF (show EGF Antibodies)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Antibodies) from accelerating cell-cycle progression.
The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.
modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.
results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.
Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
nuclear receptor subfamily 1 group I member 2
, orphan nuclear receptor PAR1
, orphan nuclear receptor PXR
, pregnane X nuclear receptor variant 2
, pregnane X receptor
, steroid and xenobiotic receptor
, Pregnane X receptor
, nuclear receptor subfamily 1, group 1, member 2
, pregnane X receptor (nuclear receptor sub family 1, group I, member 2)