NR1I2 antibody (AA 1-142)

Catalog No. ABIN5542365

Product Details anti-NR1I2 Antibody

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Binding Specificity: AA 1-142

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR1I2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Immunogen: Purified recombinant fragment of human NR1I2 (AA 1-142) expressed in E. Coli.

Clone: 6H11D8

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: , FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.05 % sodium azide

Storage: 4 °C,-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for NR1I2

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Alternative Name: NR1I2 (NR1I2 Products)

Background: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.,

Molecular Weight: 9.8kDa

HGNC: 51529

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway