NR1I2 antibody (AA 1-142)

Catalog No. ABIN5542365

The Mouse Monoclonal anti-NR1I2 antibody is suitable to detect NR1I2 in samples from Human. It has been validated for ELISA and FACS.

Quick Overview for NR1I2 antibody (AA 1-142) (ABIN5542365)

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR1I2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 6H11D8

Product Details anti-NR1I2 Antibody

Binding Specificity: AA 1-142

Purpose: NR1I2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NR1I2 (AA:1-142) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for NR1I2

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Alternative Name: NR1I2

Background: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Molecular Weight: 49.8 kDa

Gene ID: 8856

UniProt: O75469

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway