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Browse our PDX1 Proteins (PDX1)

Full name:
Pancreatic and Duodenal Homeobox 1 Proteins (PDX1)
On www.antibodies-online.com are 10 Pancreatic and Duodenal Homeobox 1 (PDX1) Proteins from 4 different suppliers available. Additionally we are shipping PDX1 Antibodies (203) and PDX1 Kits (8) and many more products for this protein. A total of 237 PDX1 products are currently listed.
Synonyms:
Ad4bp, Ad4BP/SF-1, ELP, ELP-3, Ftz-F1, Ftzf1, GSF, IDX-1, Idx1, IPF-1, Ipf1, IUF1, Mody4, pdx-1, PDX1, Sf-1, SF1, STF-1, Stf1, XlHbox-8, xlhbox8, zgc:100874
list all proteins Gene Name GeneID UniProt
PDX1 26423 P33242
PDX1 83826 P50569
PDX1 3651 P52945

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PDX1 Proteins (PDX1) by Origin

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More Proteins for PDX1 Interaction Partners

Mouse (Murine) Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Ets-1 (show ETS1 Proteins) links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes.

  2. Data indicate that KrasG12D;Pdx1-Cre mouse model enables one to monitor the progression of pancreatic cancer (PC) from the onset of precursor lesions to cancer development.

  3. Pdx1+Sox9 (show SOX9 Proteins) co-occupy regulatory sequences of pancreatic and intestinal genes. Pdx1+Sox9 (show SOX9 Proteins) are necessary and sufficient to repress the intestinal fate choice.

  4. The paper identifies two conserved Pdx1 binding sites in the epithelial cadherin (E-cad (show CDH1 Proteins), Cdh1 (show CDH1 Proteins)) promoter, and shows that Pdx1 directly binds and activates E-cad (show CDH1 Proteins) transcription.

  5. SF-1 (show SF1 Proteins) is needed for proper development of fetal and adult Leydig cells but with distinct primary functions

  6. Introduction of the PDX1 gene makes cells acquire a functional insulin (show INS Proteins) secretory capacity

  7. physiological and pathophysiological conditions dynamically regulated Pdx1 binding to these Swi (show SMARCA1 Proteins)/Snf (show SNRPA Proteins) complexes in vivo

  8. The novel Pdx1-Clec16a-Nrdp1 (show RNF41 Proteins) pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.

  9. NR5A1 (show NR5A1 Proteins) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Proteins) accumulation

  10. The results suggest that gonadal steroids do not influence the production of neurosteroids in the fetal brain, nor does SF-1 (show SF1 Proteins) play a major role in the regulation of steroidogenic enzyme expression in the brain.

Human Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. The ERK (show EPHB2 Proteins)-PDX-1 interaction in PANC-1 cells.

  2. Foxo1 (show FOXO1 Proteins) and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.

  3. This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.

  4. the human Pdx1 is highly effective in triggering human biliary tree stem cells differentiation toward functional beta-pancreatic cells.

  5. Introduction of the PDX1 gene makes cells acquire a functional insulin (show INS Proteins) secretory capacity

  6. These results suggest that IFN-gamma induced (show SAMHD1 Proteins) beta-cell dysfunction is mediated through decreased nuclear localization of Pdx-1.

  7. The rs12255372 SNP of TCF7L2 (show TCF7L2 Proteins) and D76N of PDX-1 genes may confer susceptibility to T2DM in the population living in Mashhad, Iran.

  8. Pdx1 has a role in pancreatic differentiation in human amniotic fluid-derived stem cells

  9. physiological and pathophysiological conditions dynamically regulated Pdx1 binding to these Swi (show SMARCA1 Proteins)/Snf (show SNRPA Proteins) complexes in vivo

  10. we found that PDX1 binds and suppresses expression of endogenous liver genes. These findings rebrand PDX1 as a context-dependent transcriptional repressor and activator within the same cell type.

Zebrafish Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment

  2. A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.

  3. Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.

Pig (Porcine) Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Report pancreatic expression of Pdx-1 in pancreas.

PDX1 Protein Profile

Protein Summary

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Alternative names and synonyms associated with PDX1

  • pancreatic and duodenal homeobox 1 (pdx1)
  • pancreatic and duodenal homeobox 1 (PDX1)
  • nuclear receptor subfamily 5, group A, member 1 (Nr5a1)
  • pancreatic and duodenal homeobox 1 (Pdx1)
  • Ad4bp protein
  • Ad4BP/SF-1 protein
  • ELP protein
  • ELP-3 protein
  • Ftz-F1 protein
  • Ftzf1 protein
  • GSF protein
  • IDX-1 protein
  • Idx1 protein
  • IPF-1 protein
  • Ipf1 protein
  • IUF1 protein
  • Mody4 protein
  • pdx-1 protein
  • PDX1 protein
  • Sf-1 protein
  • SF1 protein
  • STF-1 protein
  • Stf1 protein
  • XlHbox-8 protein
  • xlhbox8 protein
  • zgc:100874 protein

Protein level used designations for PDX1

pancreatic and duodenal homeobox 1 , pancreas/duodenum homeobox protein 1 , STF-1 , adrenal 4-binding protein , embryonal LTR-binding protein , embryonal long terminal repeat-binding protein , fushi tarazu 1 factor homolog , fushi tarazu factor homolog 1 , steroid hormone receptor Ad4BP , steroid hydroxylase positive regulator , steroidogenic factor 1 , IPF-1 , IUF-1 , glucose-sensitive factor , insulin promoter factor 1, homeodomain transcription factor , insulin upstream factor 1 , islet/duodenum homeobox-1 , pancreatic-duodenal homeobox factor 1 , somatostatin transcription factor 1 , somatostatin-transactivating factor 1 , pancreatic and duodenum homeobox 1 , pancreatic duodenal homeobox gene 1 , islet/duodenum homeobox 1 , pancreatic and duodenal homeobox gene 1 , IDX-1 , Insulin promoter factor 1 , insulin promotor factor 1 , somatostatin transactivating factor 1 , homeodomain protein PDX1 , homeodomain protein PDX-1 , Homeobox protein 8 , XlHbox 8 protein

GENE ID SPECIES
100101706 Xenopus (Silurana) tropicalis
100240682 Felis catus
100286705 Salmo salar
26423 Mus musculus
83826 Rattus norvegicus
3651 Homo sapiens
493994 Canis lupus familiaris
18609 Mus musculus
29535 Rattus norvegicus
30721 Danio rerio
452507 Pan troglodytes
771348 Gallus gallus
397288 Sus scrofa
538927 Bos taurus
100337610 Xenopus laevis
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