Browse our PDX1 Proteins (PDX1)

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Pancreatic and Duodenal Homeobox 1 Proteins (PDX1)
On are 11 Pancreatic and Duodenal Homeobox 1 (PDX1) Proteins from 5 different suppliers available. Additionally we are shipping PDX1 Antibodies (216) and PDX1 Kits (12) and many more products for this protein. A total of 253 PDX1 products are currently listed.
Ad4bp, Ad4BP/SF-1, ELP, ELP-3, Ftz-F1, Ftzf1, GSF, IDX-1, Idx1, IPF-1, Ipf1, IUF1, Mody4, pdx-1, PDX1, Sf-1, SF1, STF-1, Stf1, XlHbox-8, xlhbox8, zgc:100874
list all proteins Gene Name GeneID UniProt
PDX1 26423 P33242
PDX1 83826 P50569
PDX1 3651 P52945

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PDX1 Proteins (PDX1) by Origin

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More Proteins for PDX1 Interaction Partners

Mouse (Murine) Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.

  2. Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (show NR5A1 Proteins) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (show STAR Proteins) and CYP11A1 (show CYP11A1 Proteins), and a resulting increase in unmetabolized cholesterol.

  3. Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic

  4. PDX1 role in beta-cell function and diabetes

  5. At the molecular level, administration of liraglutide induced the expression of PDX-1, MafA (show MAFA Proteins), p-JAK2 (show JAK2 Proteins) and p-Stat3 (show STAT3 Proteins) in high-fat diet-induced diabetes model to relatively normal levels.

  6. Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation

  7. These results suggest that Bax (show BAX Proteins) mediates beta-cell apoptosis in Pdx1-deficient diabetes.

  8. the role of Epidermal Growth Factor (EGF (show EGF Proteins)) and Poly-L-Ornithine (PLO) and PDX1 on human amnion epithelial cell differentiation process, is reported.

  9. Ets-1 (show ETS1 Proteins) links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes.

  10. Data indicate that KrasG12D;Pdx1-Cre mouse model enables one to monitor the progression of pancreatic cancer (PC) from the onset of precursor lesions to cancer development.

Human Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.

  2. Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb (show INHBB Proteins) is identified as one factor mediating the proliferative effect of Pdx-1.

  3. Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.

  4. Pdx1 and MafA (show KLRG1 Proteins) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA (show KLRG1 Proteins) were significantly upregulated after a sleeve gastrectomy for morbid obesity.

  5. Data show that the expression patterns of sex determining region Y-box 2 (SOX2 (show SOX2 Proteins)) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).

  6. The ERK (show EPHB2 Proteins)-PDX-1 interaction in PANC-1 cells.

  7. Foxo1 (show FOXO1 Proteins) and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.

  8. This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.

  9. the human Pdx1 is highly effective in triggering human biliary tree stem cells differentiation toward functional beta-pancreatic cells.

  10. Introduction of the PDX1 gene makes cells acquire a functional insulin (show INS Proteins) secretory capacity

Zebrafish Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment

  2. A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.

  3. Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.

Pig (Porcine) Pancreatic and Duodenal Homeobox 1 (PDX1) interaction partners

  1. Report pancreatic expression of Pdx-1 in pancreas.

PDX1 Protein Profile

Protein Summary

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Alternative names and synonyms associated with PDX1

  • pancreatic and duodenal homeobox 1 (pdx1)
  • pancreatic and duodenal homeobox 1 (PDX1)
  • nuclear receptor subfamily 5, group A, member 1 (Nr5a1)
  • pancreatic and duodenal homeobox 1 (Pdx1)
  • Ad4bp protein
  • Ad4BP/SF-1 protein
  • ELP protein
  • ELP-3 protein
  • Ftz-F1 protein
  • Ftzf1 protein
  • GSF protein
  • IDX-1 protein
  • Idx1 protein
  • IPF-1 protein
  • Ipf1 protein
  • IUF1 protein
  • Mody4 protein
  • pdx-1 protein
  • PDX1 protein
  • Sf-1 protein
  • SF1 protein
  • STF-1 protein
  • Stf1 protein
  • XlHbox-8 protein
  • xlhbox8 protein
  • zgc:100874 protein

Protein level used designations for PDX1

pancreatic and duodenal homeobox 1 , pancreas/duodenum homeobox protein 1 , STF-1 , adrenal 4-binding protein , embryonal LTR-binding protein , embryonal long terminal repeat-binding protein , fushi tarazu 1 factor homolog , fushi tarazu factor homolog 1 , steroid hormone receptor Ad4BP , steroid hydroxylase positive regulator , steroidogenic factor 1 , IPF-1 , IUF-1 , glucose-sensitive factor , insulin promoter factor 1, homeodomain transcription factor , insulin upstream factor 1 , islet/duodenum homeobox-1 , pancreatic-duodenal homeobox factor 1 , somatostatin transcription factor 1 , somatostatin-transactivating factor 1 , pancreatic and duodenum homeobox 1 , pancreatic duodenal homeobox gene 1 , islet/duodenum homeobox 1 , pancreatic and duodenal homeobox gene 1 , IDX-1 , Insulin promoter factor 1 , insulin promotor factor 1 , somatostatin transactivating factor 1 , homeodomain protein PDX1 , homeodomain protein PDX-1 , Homeobox protein 8 , XlHbox 8 protein

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26423 Mus musculus
83826 Rattus norvegicus
3651 Homo sapiens
493994 Canis lupus familiaris
18609 Mus musculus
29535 Rattus norvegicus
30721 Danio rerio
452507 Pan troglodytes
771348 Gallus gallus
397288 Sus scrofa
538927 Bos taurus
100337610 Xenopus laevis
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