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These results suggest that Oc1 (show ONECUT1 Proteins) and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 (show ME1 Proteins) and Mthfd2 (show MTHFD2 Proteins) genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 (show ME1 Proteins) = malic enzyme 1 (show ME1 Proteins); Mthfd2 (show MTHFD2 Proteins) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
Data suggest that hepatocytes can be reprogrammed into insulin (show INS Proteins)-producing cells in vivo by transfection of neurogenin-3 (show NEUROG3 Proteins), Pdx1, and MafA (show MAFA Proteins) genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA (show MAFA Proteins) = v-maf (show MAF Proteins) musculoaponeurotic fibrosarcoma oncogene (show RAB1A Proteins) family, protein A (show GPR153 Proteins))
PDX1 and ISL1 (show ISL1 Proteins) regulation of insulin (show INS Proteins) gene expression in pancreatic beta cells, was investigated.
WT1 (show WT1 Proteins) is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (show SF1 Proteins) expression. Without Wt1 (show WT1 Proteins), the expression of Sf1 (show SF1 Proteins) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
Creating the Pdx1(DeltaAREAII) state after cells entered an insulin (show INS Proteins)-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions.
The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.
Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (show NR5A1 Proteins) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (show STAR Proteins) and CYP11A1 (show CYP11A1 Proteins), and a resulting increase in unmetabolized cholesterol.
Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic
PDX1 role in beta-cell function and diabetes
Efficiency of differentiation of Induced pluripotent stem cells to insulin (show INS Proteins) producing cells can be increased by concurrent expression of PDX1 and NKX6.1 (show NKX6-1 Proteins) during progenitor cells maturation.
Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.
Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb (show INHBB Proteins) is identified as one factor mediating the proliferative effect of Pdx-1.
Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.
Pdx1 and MafA (show KLRG1 Proteins) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA (show KLRG1 Proteins) were significantly upregulated after a sleeve gastrectomy for morbid obesity.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2 (show SOX2 Proteins)) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
The ERK (show EPHB2 Proteins)-PDX-1 interaction in PANC-1 cells.
Foxo1 (show FOXO1 Proteins) and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.
This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.
the human Pdx1 is highly effective in triggering human biliary tree stem cells differentiation toward functional beta-pancreatic cells.
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment
A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.
Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.
Report pancreatic expression of Pdx-1 in pancreas.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
pancreatic and duodenal homeobox 1
, pancreas/duodenum homeobox protein 1
, adrenal 4-binding protein
, embryonal LTR-binding protein
, embryonal long terminal repeat-binding protein
, fushi tarazu 1 factor homolog
, fushi tarazu factor homolog 1
, steroid hormone receptor Ad4BP
, steroid hydroxylase positive regulator
, steroidogenic factor 1
, glucose-sensitive factor
, insulin promoter factor 1, homeodomain transcription factor
, insulin upstream factor 1
, islet/duodenum homeobox-1
, pancreatic-duodenal homeobox factor 1
, somatostatin transcription factor 1
, somatostatin-transactivating factor 1
, pancreatic and duodenum homeobox 1
, pancreatic duodenal homeobox gene 1
, islet/duodenum homeobox 1
, pancreatic and duodenal homeobox gene 1
, Insulin promoter factor 1
, insulin promotor factor 1
, somatostatin transactivating factor 1
, homeodomain protein PDX1
, homeodomain protein PDX-1
, Homeobox protein 8
, XlHbox 8 protein