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Data, including data from knockout mice, suggest critical role for PPARalpha in endocrine disruptor-/herbicide-/2,4-dichlorophenoxyacetic acid-induced male infertility due to disruption of spermatogenesis and cholesterol/testosterone homeostasis in Leydig cells of testis.
Inhibition of PPAR-alpha is associated with protection against doxorubicin-induced cardiotoxicity in mice, and cannabinoids can potentiate the protection by PPAR-alpha blockade.
Data show that peroxisome proliferator activated receptor alpha (PPARalpha) deficiency alters the migratory abilities and expression of chemokine (show CCL1 Proteins) receptors.
The PPARalpha and PGC-1alpha are closely involved in energy metabolism remodeling and apoptosis in cardiomyocytes.
the new pathological mechanism of acute liver failure (ALF (show GTF2A1L Proteins)) that the increased GSK3beta activity suppresses autophagy to promote the occurrence and development of ALF (show GTF2A1L Proteins) by inhibiting PPARalpha pathway.
the protective effect of PPARalpha activation against cardiac ischemia-reperfusion injury in terms of the expression of uncoupling protein (UCP (show UCP1 Proteins)), was investigated.
This study evaluated the effects of Boiogito on kidney proximal epithelial cells via the PPARalpha-CREB (show CREB1 Proteins) protein complex.
miR (show MLXIP Proteins)-130b played important profibrotic roles in SSc (show CYP11A1 Proteins) fibrosis, and enhanced TGF-beta (show TGFB1 Proteins) signaling through negative regulation of PPARgamma (show PPARG Proteins) expression.
Downregulation of miR (show MLXIP Proteins)-34a may be a therapeutic strategy against nonalcoholic fatty liver disease by regulating its target PPARalpha and SIRT1 (show SIRT1 Proteins).
hepatic CEACAM1 (show CEACAM1 Proteins) expression at fasting is mediated by Pparalpha-dependent mechanisms.
The effects of fenofibrate on nonalcoholic fatty liver disease in the context of PPAR-alpha activation was studied.
PPARA polymorphism is associated with the risk of coronary heart disease.
Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPARdelta (show PPARD Proteins)/STAT3 (show STAT3 Proteins) pathway.
A modest relationship was found between PPARalpha and AIP (show AIP Proteins) expression, both being significantly higher in the presence of pre-operative somatostatin (show SST Proteins) analogues in somatotropinoma patients.
Fenofibrate inhibited atrial metabolic remodeling in atrial fibrillation (AF) by regulating the PPAR-alpha/sirtuin 1/PGC-1alpha pathway indicating a novel therapeutic strategy for AF
PPAR delta + 294TT genotype frequency in the Chinese Han population was higher than in the Chinese Uyghur population and may affect the risk of ischemic stroke.
PPARalpha functions as an E3 ubiquitin ligase (show MUL1 Proteins) to induce Bcl2 (show BCL2 Proteins) ubiquitination and degradation, leading to increased cancer cell sensitivity in response to chemotherapy drugs.
There was no statistically significant difference in the distribution of PPARalpha Leu162Val polymorphism between the ischemic stroke patients and controls in the Han ethnic group.
results support an important association between rs1800206 minor allele (V) of PPAR alpha and lower CRP (show CRP Proteins) level; the interaction analysis showed a combined effect between rs1800206 and rs135539 on the lower CRP (show CRP Proteins) level
PPAR-gamma (show PPARG Proteins) and PTEN expressions are related to the clinical parameters and prognosis of renal cell carcinoma (show MOK Proteins)
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Proteins) (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (show PPARG Proteins)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Proteins) levels in bovine endometrial stromal cells.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
peroxisome proliferator-activated receptor alpha
, ppar alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor-alpha
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, xPPAR alpha