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GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha-FGF21 (show FGF21 Proteins) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
These findings reveal a novel BVRA (show BLVRA Proteins)-GSKbeta-PPARalpha axis that regulates hepatic lipid metabolism and may provide unique targets for the treatment of non-alcoholic fatty liver disease.
CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARalpha-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.
This study indicates that PPAR alpha activation drives demethylation of the CpG islands of the Gadd45b (show GADD45B Proteins) promoter in the mouse liver and that epigenetic change at the Gadd45b (show GADD45B Proteins) promoter is critical for Gadd45b (show GADD45B Proteins) induction.
Cyp1b1 (show CYP1B1 Proteins) affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha (show HNF4A Proteins) and PPARalpha.
Chronic stimulation of PPARalpha may suppress the autophagy capacity in the liver as a result of reduced content of a number of autophagy-associated proteins independent of FGF21 (show FGF21 Proteins).
The results indicate that alterations in PGC (show PGC Proteins)-1a acetylation and expression level might contribute to the regulation of melanogenesis by PPARalpha and fenofibrate.
Inhibition of adipose tissue PPARgamma (show PPARG Proteins) prevented LipX-induced increases in adipocyte expansion and produced a glucose-intolerant phenotype
Data, including data from knockout mice, suggest critical role for PPARalpha in endocrine disruptor-/herbicide-/2,4-dichlorophenoxyacetic acid-induced male infertility due to disruption of spermatogenesis and cholesterol/testosterone homeostasis in Leydig cells of testis.
Inhibition of PPAR-alpha is associated with protection against doxorubicin-induced cardiotoxicity in mice, and cannabinoids can potentiate the protection by PPAR-alpha blockade.
Studies indicate that natural dietary compounds, including nutrients and phytochemicals, are Peroxisome proliferator-activated receptor alpha (PPARalpha) ligands or modulators.
Genome-wide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR (show NR1I2 Proteins) and PPARalpha in primary human hepatocytes has been presented.
Hepatitis B virus increases the expression of alpha-mannosidases both in vitro and in vivo via activation of the PPARalpha pathway by its envelope protein.
PPARalpha activation plays defensive and compensative roles by reducing cellular toxicity associated with fatty acids and sulfuric acid.
PPARalpha/gamma agonist, elafibranor resolves nonalcoholic steatohepatitis without worsening fibrosis.
The effects of fenofibrate on nonalcoholic fatty liver disease in the context of PPAR-alpha activation was studied.
PPARA polymorphism is associated with the risk of coronary heart disease.
Telmisartan improved the hyperglycemia-induced cardiac fibrosis through the PPARdelta (show PPARD Proteins)/STAT3 (show STAT3 Proteins) pathway.
A modest relationship was found between PPARalpha and AIP (show AIP Proteins) expression, both being significantly higher in the presence of pre-operative somatostatin (show SST Proteins) analogues in somatotropinoma patients.
Fenofibrate inhibited atrial metabolic remodeling in atrial fibrillation (AF) by regulating the PPAR-alpha/sirtuin 1/PGC-1alpha pathway indicating a novel therapeutic strategy for AF
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Proteins) (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (show PPARG Proteins)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Proteins) levels in bovine endometrial stromal cells.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
peroxisome proliferator-activated receptor alpha
, ppar alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor-alpha
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, xPPAR alpha