Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
the protective effect of PPARalpha activation against cardiac ischemia-reperfusion injury in terms of the expression of uncoupling protein (UCP (show UCP1 Proteins)), was investigated.
This study evaluated the effects of Boiogito on kidney proximal epithelial cells via the PPARalpha-CREB (show CREB1 Proteins) protein complex.
miR (show MLXIP Proteins)-130b played important profibrotic roles in SSc (show CYP11A1 Proteins) fibrosis, and enhanced TGF-beta (show TGFB1 Proteins) signaling through negative regulation of PPARgamma (show PPARG Proteins) expression.
Downregulation of miR (show MLXIP Proteins)-34a may be a therapeutic strategy against nonalcoholic fatty liver disease by regulating its target PPARalpha and SIRT1 (show SIRT1 Proteins).
hepatic CEACAM1 (show CEACAM1 Proteins) expression at fasting is mediated by Pparalpha-dependent mechanisms.
Bilirubin Binding to PPARalpha Inhibits Lipid Accumulation
Pparalpha complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function
Cardiac myocyte KLF5 (show KLF5 Proteins) is a transcriptional regulator of Ppara and cardiac energetics.
prior voluntary exercise suppresses the expression of pro-inflammatory cytokines in the colon in response to inflammatory challenge by up-regulating glucocorticoid-mediated PPAR-gamma (show PPARG Proteins) activity
The optimal PPARalpha/RXRalpha (show RXRA Proteins) heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha (show RXRA Proteins) to DNA, attenuated PPARalpha-induced transcriptional activation, but this is not always true for PPARalpha.
results support an important association between rs1800206 minor allele (V) of PPAR alpha and lower CRP (show CRP Proteins) level; the interaction analysis showed a combined effect between rs1800206 and rs135539 on the lower CRP (show CRP Proteins) level
PPAR-gamma (show PPARG Proteins) and PTEN expressions are related to the clinical parameters and prognosis of renal cell carcinoma (show MOK Proteins)
Describe a renoprotective role of fenofibrate in albumin (show ALB Proteins) bound fatty acid associated tubular toxicity, involving the transcriptional activation of PPARalpha and suppression of NF-kB.
Supplementation with the PPARalpha agonist WY14643 improved the homeostasis and barrier function of filaggrin (show FLG Proteins) deficient skin models by normalization of the free fatty acid profile.
PPAR agonists troglitazone and aleglitazar reverse doxorubicin resistance of human myelogenous leukemia cells.
we show that fenofibrate, a PPAR-alpha agonist, increased the expression of miR (show MLXIP Proteins)-301a/miR (show MLXIP Proteins)-454 and SKA2 (show FAM33A Proteins) in human microvascular endothelial cell line (HMEC) cells; the former were responsible for reduced expression of ET-1 (show EDN1 Proteins) and PAI-1 (show SERPINE1 Proteins)
this is the first study to report that 9-oxo-OTA promotes fatty acid metabolism via PPARalpha activation and discuss its potential as a valuable food-derived compound for use in the management of dyslipidemia.
Evidence that multiple PPARalpha/delta/gamma gene polymorphisms are individually associated with increased low-density lipoprotein-cholesterol, and that interactions, among these alleles result in additional increased risk suggesting that PPAR genes may contribute substantially to the risk of cardiovascular diseases and atherosclerosis.
Both PPARA and PPARGC1A regulate transcription of genes commonly regulated by glycolysis, by the antidiabetic agent metformin and by NOX, suggesting their major interplay in the control of hepatocellular carcinoma progression
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Proteins) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Proteins) (SSC10p13) and CREB (show CREB1 Proteins) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (show SLC22A5 Proteins) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (show PPARG Proteins)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Proteins) levels in bovine endometrial stromal cells.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
peroxisome proliferator-activated receptor alpha
, ppar alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor-alpha
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, xPPAR alpha