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anti-Human RORC Antibodies:
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The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut (show GUSB Antibodies)-specific immune responses, rendering Foxp3 (show FOXP3 Antibodies)-RORgt T cells as an important effector Treg subset in the intestinal system.
Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 (show IL22 Antibodies) and GFP (RORgammat)
Epidermal Notch1 (show NOTCH1 Antibodies) recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
injected chlorhexidine gluconate into wild-type, T-bet Tg, GATA-3 (show GATA3 Antibodies) Tg, and RORgammat Tg mice and analyzed body weight on day 21
Dysregulated development of IL-17 (show IL17A Antibodies)- and IL-21 (show IL21 Antibodies)-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
BET bromodomains are involved in psoriasis-like inflammation through induction of RORC/IL-17A (show IL17A Antibodies) pathway.
High-fat diet - induced type 2 diabetes decreases the number of ileum IL17 (show IL17A Antibodies)/RORgammaT CD4 (show CD4 Antibodies) T cells.
These results suggest that both RORgammat-overexpressed CD4 (show CD4 Antibodies)(+) T cells and reduced Treg cells might contribute to the development of Sjogren's syndrome -like sialadenitis.
mucosal draining lymph nodes express CCR7 (show CCR7 Antibodies), which has a role in trafficking of RORgamma innate lymphoid cells
RORgammat overexpression in T cells protected against the development of CIA (show NCOA5 Antibodies).
Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock (By similarity). Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.
RAR-related orphan receptor gamma
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoid-related orphan receptor-gamma
, thymus orphan receptor