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Results from the study establish RORgamma as a key player in castration-resistant prostate cancer (CRPCa) by acting upstream of AR and as a new therapeutic target for advanced PCa (show FLVCR1 Proteins).
MiR-16 (show GDE1 Proteins) may be involved in Th17/Treg imbalance in rheumatoid arthritis patients by affecting the expression of RORgt and FoxP3 (show FOXP3 Proteins).
Serum RORC levels was higher in rheumatoid arthritis (RA) patients with rs9826AA, rs12045886TT and -TC, and rs9017AA genotypes compared to healthy subjects with the same genotypes (p = 0.02, p = 0.04 and p = 0.01, respectively).
The findings suggest that RORC plays a significant role in the dysregulated immune response associated with lupus erythematosus (SLE) .
RORgammat is acetylated, and this acetylation is reciprocally regulated by the histone acetyltransferase p300 (show EP300 Proteins) and the histone deacetylase HDAC1 (show HDAC1 Proteins).
A high copy number of T-bet and GATA-3 (show GATA3 Proteins) confers susceptibility to AAU and AS, and a high copy number of FOXP3 (show FOXP3 Proteins) confers susceptibility to female patients with AAU either with or without AS.
melatonin suppresses HIF-1alpha (show HIF1A Proteins) accumulation and VEGF (show VEGFA Proteins) generation via inhibition of melatonin nuclear receptor RZR/RORgamma in SGC (show SGCB Proteins)-7901 cells under hypoxia.
The mRNA expression of RORC, TNF-alpha (show TNF Proteins) and IL-6 (show IL6 Proteins) was significantly high in CC patients
the balance between the transcription factors of Treg and Th17 cells (FoXp3 (show FOXP3 Proteins) and RORgammat) was sought as a molecular marker of disease activity and to highlight the pathogenesis of autoimmune liver diseases
findings reveal a direct link between TRAF5 (show TRAF5 Proteins)-mediated ubiquitination and RORgammat protein regulation
The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle
The role of the orphan receptor (show NR1D2 Proteins) C allele variation on intramuscular fat in beef cattle is reported.
The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut (show GUSB Proteins)-specific immune responses, rendering Foxp3 (show FOXP3 Proteins)-RORgt T cells as an important effector Treg subset in the intestinal system.
Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 (show IL22 Proteins) and GFP (RORgammat)
Epidermal Notch1 (show NOTCH1 Proteins) recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
injected chlorhexidine gluconate into wild-type, T-bet Tg, GATA-3 (show GATA3 Proteins) Tg, and RORgammat Tg mice and analyzed body weight on day 21
Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21 (show IL21 Proteins)-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.
BET bromodomains are involved in psoriasis-like inflammation through induction of RORC/IL-17A (show IL17A Proteins) pathway.
High-fat diet - induced type 2 diabetes decreases the number of ileum IL17 (show IL17A Proteins)/RORgammaT CD4 (show CD4 Proteins) T cells.
These results suggest that both RORgammat-overexpressed CD4 (show CD4 Proteins)(+) T cells and reduced Treg cells might contribute to the development of Sjogren's syndrome -like sialadenitis.
mucosal draining lymph nodes express CCR7 (show CCR7 Proteins), which has a role in trafficking of RORgamma innate lymphoid cells
RORgammat overexpression in T cells protected against the development of CIA (show NCOA5 Proteins).
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
RAR-related orphan nuclear receptor variant 2
, nuclear receptor ROR-gamma
, nuclear receptor RZR-gamma
, nuclear receptor subfamily 1 group F member 3
, retinoic acid-binding receptor gamma
, retinoid-related orphan receptor gamma
, RAR-related orphan receptor gamma
, retinoid-related orphan receptor-gamma
, thymus orphan receptor