Browse our RORC Proteins (RORC)

On are 12 RAR-Related Orphan Receptor C (RORC) Proteins from 6 different suppliers available. Additionally we are shipping RORC Antibodies (167) and RORC Kits (20) and many more products for this protein. A total of 217 RORC products are currently listed.
Nr1f3, RORG, RORgamma, RZR-GAMMA, RZRG, Thor, TOR
list all proteins Gene Name GeneID UniProt
RORC 6097 P51449
Rat RORC RORC 368158  
RORC 19885 P51450

RORC Proteins (RORC) by Origin

More Proteins for RORC Interaction Partners

Human RAR-Related Orphan Receptor C (RORC) interaction partners

  1. There are 2 putative binding motifs for specificity protein transcription factors from the specificity protein/Kruppel-like factor family in the promoter of human RORgammaT. SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression.

  2. Results from the study establish RORgamma as a key player in castration-resistant prostate cancer (CRPCa) by acting upstream of AR and as a new therapeutic target for advanced PCa (show FLVCR1 Proteins).

  3. Data suggest that apo (show C9orf3 Proteins) RORC adopts active conformation capable of recruiting coactivator peptides that stabilize helix 12 of the active state in the absence of a ligand; ligand-bound RORC binds inverse agonists that disrupt critical interactions that stabilize helix 12; helix 12 destabilization in the active state shifts the conformational equilibrium of RORC toward an inactive state.

  4. Retinoid-related orphan receptor (show NR1D2 Proteins) gammat may be associated with NK22 cells in reproduction. Particularly, higher expression of retinoid-related orphan receptor (show NR1D2 Proteins) gammat may be associated with elevated NK22 cells in unexplained recurrent pregnancy loss.

  5. MiR-16 (show GDE1 Proteins) may be involved in Th17/Treg imbalance in rheumatoid arthritis patients by affecting the expression of RORgt and FoxP3 (show FOXP3 Proteins).

  6. Serum RORC levels was higher in rheumatoid arthritis (RA) patients with rs9826AA, rs12045886TT and -TC, and rs9017AA genotypes compared to healthy subjects with the same genotypes (p = 0.02, p = 0.04 and p = 0.01, respectively).

  7. The findings suggest that RORC plays a significant role in the dysregulated immune response associated with lupus erythematosus (SLE) .

  8. RORgammat is acetylated, and this acetylation is reciprocally regulated by the histone acetyltransferase p300 (show EP300 Proteins) and the histone deacetylase HDAC1 (show HDAC1 Proteins).

  9. A high copy number of T-bet and GATA-3 (show GATA3 Proteins) confers susceptibility to AAU and AS, and a high copy number of FOXP3 (show FOXP3 Proteins) confers susceptibility to female patients with AAU either with or without AS.

  10. melatonin suppresses HIF-1alpha (show HIF1A Proteins) accumulation and VEGF (show VEGFA Proteins) generation via inhibition of melatonin nuclear receptor RZR/RORgamma in SGC (show SGCB Proteins)-7901 cells under hypoxia.

Cow (Bovine) RAR-Related Orphan Receptor C (RORC) interaction partners

  1. The total frequencies for the combined genotypes for the bGH and RORC genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle

  2. The role of the orphan receptor (show NR1D2 Proteins) C allele variation on intramuscular fat in beef cattle is reported.

Mouse (Murine) RAR-Related Orphan Receptor C (RORC) interaction partners

  1. ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1 (show NCOA1 Proteins)

  2. RORgamma/IL-17A (show IL17A Proteins) axis influences VEGF (show VEGFA Proteins) production and neovascular retinopathy by mechanisms involving neuroglia. Inhibition of RORgamma and IL-17A (show IL17A Proteins) may have potential for the improved treatment of neovascular retinopathies.

  3. secretion of IL-17 (show IL17A Proteins) by biTregs was abrogated completely in FoxP3 (show FOXP3 Proteins)(Cre) x RORC(fl/fl (show FLT3LG Proteins)) mice. Furthermore, Tregs showed a more activated phenotype after cell-specific inactivation of RORgammat signalling. Finally, and remarkably, biTregs were found to potently suppress anti-inflammatory Th2 immunity in a RORgammat-dependent manner.

  4. this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression

  5. The data suggest that RORgt expression in Tregs contributes to an optimal suppressive capacity during gut (show GUSB Proteins)-specific immune responses, rendering Foxp3 (show FOXP3 Proteins)-RORgt T cells as an important effector Treg subset in the intestinal system.

  6. Rag-RORgammat-reporter and Rag KO mice undergoing ischemia reperfusion injury expressed high protein levels of both IL-22 (show IL22 Proteins) and GFP (RORgammat)

  7. Epidermal Notch1 (show NOTCH1 Proteins) recruits RORgamma(+) group 3 innate lymphoid cells to orchestrate normal skin repair.

  8. injected chlorhexidine gluconate into wild-type, T-bet Tg, GATA-3 (show GATA3 Proteins) Tg, and RORgammat Tg mice and analyzed body weight on day 21

  9. Dysregulated development of IL-17 (show IL17A Proteins)- and IL-21 (show IL21 Proteins)-expressing follicular helper T cells and increased germinal center formation in the absence of RORgammat.

  10. BET bromodomains are involved in psoriasis-like inflammation through induction of RORC/IL-17A (show IL17A Proteins) pathway.

RORC Protein Profile

Protein Summary

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known\; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with RORC

  • RAR-related orphan receptor C (RORC)
  • RAR-related orphan receptor C (Rorc)
  • RAR-related orphan receptor gamma (Rorc)
  • Nr1f3 protein
  • RORG protein
  • RORgamma protein
  • RZR-GAMMA protein
  • RZRG protein
  • Thor protein
  • TOR protein

Protein level used designations for RORC

RAR-related orphan nuclear receptor variant 2 , nuclear receptor ROR-gamma , nuclear receptor RZR-gamma , nuclear receptor subfamily 1 group F member 3 , retinoic acid-binding receptor gamma , retinoid-related orphan receptor gamma , RAR-related orphan receptor gamma , retinoid-related orphan receptor-gamma , thymus orphan receptor

6097 Homo sapiens
483205 Canis lupus familiaris
527470 Bos taurus
368158 Rattus norvegicus
19885 Mus musculus
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