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a Gbetagamma-activated AC is playing an important role in Xenopus oocyte meiotic arrest in a Galphas (show GNAS Proteins)-GTP (show AK3 Proteins) dependent manner.
AK7 may be involved in the development of Primary ciliary dyskinesia (PCD).
Both AK7 and full-length AK8 (show AK8 Proteins) showed highest affinity for AMP (show APRT Proteins) with ATP as the phosphate donor, and proved to be more efficient in AMP (show APRT Proteins) phosphorylation as compared with the major cytosolic isoform AK1 (show AK1 Proteins)
Data show that a mutation of the adenylate kinase 7 gene results in animals with pathological signs characteristic of primary ciliary dyskinesia, including ultrastructural ciliary defects and decreased ciliary beat frequency in respiratory epithelium.
Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP.
putative adenylate kinase 7
, adenylate kinase 7
, putative adenylate kinase 7-like
, ATP-AMP transphosphorylase 7