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Browse our RP2 Proteins (RP2)

Full name:
Retinitis Pigmentosa 2 (X-Linked Recessive) Proteins (RP2)
On are 1 Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) Proteins from 1 different suppliers available. A total of 2 RP2 products are currently listed.
AI662636, DELXp11.3, NM23-H10, NME10, RGD1565124, Rp2, Rp2h, TBCCD2, wu:fj10e02, wu:fm72d05, XRP2, zfrp2, zgc:55632
list all proteins Gene Name GeneID UniProt
Rat RP2 RP2 367714  
Human RP2 RP2 6102 O75695
Mouse RP2 RP2 19889 Q9EPK2

Show all synonyms

More Proteins for RP2 Interaction Partners

Zebrafish Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. maternal rp2 mRNA is essential for successful embryonic development and thus contributes to egg developmental competence

  2. Knockout of RP2 decreases GRK1 (show GRK1 Proteins) and rod transducin (show GNAT1 Proteins) subunits and leads to photoreceptor degeneration in zebrafish

  3. Results suggest that RP2 plays a key role in photoreceptor development and maintenance in zebrafish

  4. Zebrafish RP2 is widely expressed throughout development. ZFRP2 knockdown caused retinal degeneration in zebrafish.

Human Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. Three XLRP families (RP-001, RP-002, and RP-003), composed of 13 individuals, were reported in this study, and 2 different mutations were detcted We found 3 genetic variants: a novel mutation c.1591G>T in exon 14 and a novel polymorphism c.1105C>T in exon 10, resulting in p.Glu531* and p.Arg369Cys of RPGR (show RPGR Proteins) gene, respectively, and one already known mutation c.413A>G in exon 2, resulting in a p.Glu138Gly of RP2 (show NUDT19 Proteins) gene

  2. We identified a novel causative mutation in RP2 (show NUDT19 Proteins) from a single proband's exome sequence data analysis. This study highlights the effectiveness of the whole-exome sequencing in the genetic diagnosis of X-linked retinitis pigmentosa, over the conventional sequencing methods.

  3. Three mutations were identified in the ORF15 (show RPGR Proteins) exon of RPGR (show RPGR Proteins). No RP2 (show NUDT19 Proteins) mutations were found among the examined families. Mutation screening of RP patients is essential to understand the mechanism behind this disease and develop treatments

  4. seven out of 27 families, displaying mutations in the ABCA4, RP1, RP2 and USH2A genes, could be genetically or clinically reclassified. These results demonstrate the potential of our panel-based NGS strategy in RP diagnosis

  5. The ability of the restored RP2 protein (show P2RX1 Proteins) level to reverse the observed cellular phenotypes in cells lacking RP2 (show NUDT19 Proteins) indicates that translational read-through could be clinically beneficial for patients.

  6. ellipsometric measurements of naRP2 demonstrated that its particular affinity for saturated phospholipids can be explained by its larger extent of insertion in this phospholipid monolayer compared to that in polyunsaturated phospholipid monolayers.

  7. The methylation state of CpG sites close to the RP2 (show NUDT19 Proteins) core promoter (GAAA)n repeat serves as a proxy measurement of X-chromosome inactivation in human and non-human primates.

  8. A novel frameshift mutation in RP2 (show NUDT19 Proteins) was detected. This mutation was located in exon 2 of the RP2 (show NUDT19 Proteins) gene: a nucleotide C was inserted at 111 (c.111insC, Fig. 1A), which caused a protein translation frameshift

  9. Direct sequencing of RPGR (show RPGR Proteins) and RP2 (show NUDT19 Proteins) allowed for identification of a disease-causing mutation in 21 families. Of these "adRP (show PLIN2 Proteins)" families 19 had RPGR (show RPGR Proteins) mutations, and two had RP2 (show NUDT19 Proteins) mutations.

  10. Based on our findings, we suggest that RPGR (show RPGR Proteins) should be considered as a first tier gene for screening isolated males with retinal degeneration.

Mouse (Murine) Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) interaction partners

  1. RP2 has a role in cone photoreceptor sensory cilium elongation in mice

  2. we first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction

  3. Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations.

  4. We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment.

RP2 Protein Profile

Protein Summary

The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death

Alternative names and synonyms associated with RP2

  • retinitis pigmentosa 2 homolog (human) (Rp2)
  • retinitis pigmentosa 2 (X-linked recessive) (RP2)
  • XRP2 protein (Bm1_36735)
  • XRP2-like protein (PITG_13367)
  • XRP2 protein (LOAG_11813)
  • XRP2 protein (LOC100338686)
  • retinitis pigmentosa 2 (X-linked recessive) (rp2)
  • retinitis pigmentosa 2 homolog (human) (Rp2h)
  • AI662636 protein
  • DELXp11.3 protein
  • NM23-H10 protein
  • NME10 protein
  • RGD1565124 protein
  • Rp2 protein
  • Rp2h protein
  • TBCCD2 protein
  • wu:fj10e02 protein
  • wu:fm72d05 protein
  • XRP2 protein
  • zfrp2 protein
  • zgc:55632 protein

Protein level used designations for RP2

protein XRP2 , retinitis pigmentosa 2 (X-linked recessive) , XRP2 protein , XRP2-like protein , protein XRP2-like , nme10 , retinitis pigmentosa 2 homolog

367714 Rattus norvegicus
465596 Pan troglodytes
534054 Bos taurus
6102232 Brugia malayi
9474509 Phytophthora infestans T30-4
9949274 Loa loa
100338686 Oryctolagus cuniculus
100468530 Ailuropoda melanoleuca
406755 Danio rerio
491853 Canis lupus familiaris
711227 Macaca mulatta
100060484 Equus caballus
100380020 Xenopus (Silurana) tropicalis
100413670 Callithrix jacchus
100460005 Pongo abelii
100622983 Sus scrofa
6102 Homo sapiens
418675 Gallus gallus
379779 Xenopus laevis
19889 Mus musculus
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