RP2 Protein (GST tag)

Catalog No. ABIN7197705

Product Details

Target: RP2 (Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This RP2 protein is labelled with GST tag.

Purpose: Recombinant Human XRP2/RP2 Protein (GST Tag)

Sequence: Met 1-Thr 350

Characteristics: A DNA sequence encoding the human XRP2 (NP_008846.2) (Met 1-Thr 350) was fused with the GST tag at the N-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 1 mM GSH 0.5 mM EDTA, 0.5 mM PMSF pH 8.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: RP2 (Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2))

Alternative Name: XRP2/RP2 (RP2 Products)

Synonyms: Rp2h Protein, RGD1565124 Protein, RP2 Protein, wu:fj10e02 Protein, wu:fm72d05 Protein, zfrp2 Protein, zgc:55632 Protein, DELXp11.3 Protein, NM23-H10 Protein, NME10 Protein, TBCCD2 Protein, XRP2 Protein, AI662636 Protein, Rp2 Protein, RP2, ARL3 GTPase activating protein Protein, XRP2 protein Protein, XRP2-like protein Protein, retinitis pigmentosa 2 (X-linked recessive) Protein, RP2, ARL3 GTPase activating protein S homeolog Protein, retinitis pigmentosa 2 homolog Protein, Rp2 Protein, RP2 Protein, Bm1_36735 Protein, PITG_13367 Protein, LOAG_11813 Protein, rp2 Protein, rp2.S Protein

Background:

Background: XRP2, also known as Protein XRP2 and RP2, is a member of the TBCC (tubulin cofactor C) family and contains one C-CAP/cofactor C-like domain. This protein is encoded by the RP2 gene in humans. XRP2 stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. XRP2 acts as guanine nucleotide dissociation inhibitor for ARL3. Defects in RP2 gene are the cause of retinitis pigmentosa type 2 (RP2), also known as X-linked retinitis pigmentosa 2 (XLRP-2). It leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 

Synonym: DELXp11.3;KIAA0215;NM23-H10;NME10;RP2;TBCCD2;XRP2

Molecular Weight: 66 kDa

NCBI Accession: NP_008846

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process