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Human BAX Protein expressed in Wheat germ - ABIN1346448
Bras, Yuste, Roué, Barbier, Sancho, Virely, Rubio, Baudet, Esquerda, Merle-Béral, Sarfati, Susin: Drp1 mediates caspase-independent type III cell death in normal and leukemic cells. in Molecular and cellular biology 2007
These results suggest a role for mitochondrial p53 (show TP53 Proteins) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax and Bcl2 (show BCL2 Proteins).
xlbax is a regulator of muscle fiber death in the regressing tail during metamorphosis.
BoHV-5 replication apparently modulates BCL-2 (show BCL2 Proteins) expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression.
It was concluded that the Fas (show FAS Proteins)-FasL (show FASL Proteins) signaling pathway was involved in regulation of bovine oocyte apoptosis, perhaps related to B (show TDO2 Proteins) cell lymphoma/leukemia-2 associated X upregulation.
apoptosis-inducing factor (show AIFM1 Proteins) was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 (show BCL2 Proteins) protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax, Bcl-2 (show BCL2 Proteins), caspase-3 (show CASP3 Proteins) and-7 cannot be used as a reliable apoptosis detection method.
The effect of culture conditions on expression of heat shock protein 70 (show HSP70 Proteins) and Bax protein in bovine blastocysts is reported.
The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 (show BCL2 Proteins) and cyclin D expression and upregulation of BAX and Bim (show BCL2L11 Proteins) expression.
the BCL2 (show BCL2 Proteins)-938C>A and BAX-248G>A SNPs significantly associated with platinum-based chemotherapy response, PFS and OS of patients with advanced NSCLC.
the recently proposed new therapies employing bcl-2 (show BCL2 Proteins) inhibitors prompted the potential use of bax/bcl-2 (show BCL2 Proteins) ratio to identify patients putatively resistant to these molecules.
Results show that PCAF (show KAT2B Proteins) can induce cell apoptosis by modulating a GLI1 (show GLI1 Proteins)/Bcl-2 (show BCL2 Proteins)/BAX axis that in turn suppresses HCC (show FAM126A Proteins) progression.
Dysadherin (show FXYD5 Proteins)-silenced side population cells exhibited reduced expression of Bcl-2 (show BCL2 Proteins) and Bax compared with that prior to silencing.
LTX-315 kills cancer cells through Bax/Bak (show BAK1 Proteins)-regulated mitochondrial membrane permeabilization
Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction.
ABL (show ABL1 Proteins)-N administration induced apoptosis of PC3 (show PCSK1 Proteins) cells in a dose-dependent manner, along with the enhanced activity of caspases and increased Bax/Bcl-2 (show BCL2 Proteins) ratio. Expression of KLF5 (show KLF5 Proteins), Stat5b (show STAT5B Proteins) and ICAM-1 (show ICAM1 Proteins) was significantly downregulated in PC3 (show PCSK1 Proteins) cells.
Data suggest that regulation of Bax stability and transport between cytosol and mitochondria is more tightly regulated by Bcl-xL/BCL2L1 (show BCL2L1 Proteins) when Bax has been phosphorylated at Ser184 by AKT1 (show AKT1 Proteins); experiments involved expression in haploid yeast strains.
Study reveals a role of SIRT3 (show SIRT3 Proteins)/GSK-3beta/Bax signaling pathway in the suppression of HCC (show FAM126A Proteins) growth.
Bim (show BCL2L11 Proteins) and Puma (show BBC3 Proteins) overlapped apoptosis only partially during physiological apoptotic stage and they were present in non-apoptotic parts of the follicles.
This study demonstated that Bax KO mice show Hyperactivity and depression.
The influence of chronic ethanol consumption on the expression of the Bdnf (show BDNF Proteins), Bax, Bcl-xL (show BCL2L1 Proteins), and CASP3 (show CASP3 Proteins) genes was studied in the brain structures of B6-1473C (C/C) and B6-1473G (G/G) mice that had been obtained on the base of the C57BL/6 strain.
These data indicate that the rapid and robust microglial activation and PIF (show DCD Proteins) expression observed in situ following acute EtOH exposure is largely driven indirectly by BAX-dependent apoptotic cell death, rather than directly by the EtOH.
lipid profile in the absence of the proapoptotic proteins BAX and BAK (show BAK1 Proteins) in mouse embryonic fibroblasts
despite its role in Bax inhibition, Bcl-xL (show BCL2L1 Proteins) also primes mitochondria to permeabilization and cytochrome c (show CYCS Proteins) release.
BAX and BAK (show BAK1 Proteins) have a nonapoptotic role in eicosanoid metabolism in inflammation.
Puma (show BBC3 Proteins) is the major mediator of virus-induced Bax/Bak (show BAK1 Proteins) activation and mitochondrial membrane permeabilization induction.
The Ca(2 (show CA2 Proteins)+) channel inhibitor 2-APB (show RNPEP Proteins) reverses beta-amyloid-induced long term potentiation deficit in hippocampus by blocking BAX and caspase-3 (show CASP3 Proteins) hyperactivation.
Although theanine had no significant effect on the doxorubicin induced elevation in the expression level of mRNA for Fas (show FAS Proteins) in the liver, the increase in hepatic expression of Bax was significantly attenuated by theanine.
Bid (show BID Proteins) and Bax are signal transduction factors in granulosa cells and play proapoptotic roles.
The data demonstrate that severe hypocapnia results in increased Bax expression, DNA fragmentation, and membrane lipid peroxidation in mitochondria of cerebral cortical neurons of newborn piglets, and may result in apoptotic cell death.
bcl-2 (show BCL2 Proteins) and bax were expressed strongly in denervated guinea-pig facial muscle. [bcl-2 (show BCL2 Proteins); bax]
goat oocytes based on G6PDH (show G6PD Proteins)-activity through the BCB test improves their developmental competence, increases intracellular GSH content, and affects the expression of the apoptosis-related genes9 Bax and Bcl-2 (show BCL2 Proteins) ).
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax and decreasing expression of bcl2 (show BCL2 Proteins).
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 (show BCL2 Proteins) and increased expression of Bax.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2-associated X protein (BAX) transcripts and protein depending on luteal stage.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
, bax zeta
, apoptosis regulator BAX
, BCL2-associated X protein
, BCL2-associated X protein omega
, BCL2-associated X protein transcript variant delta2
, bcl-2-like protein 4
, BCL2-associated protein