Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human C-MYC Protein expressed in HEK-293 Cells - ABIN2715370
Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: Sin3b interacts with Myc and decreases Myc levels. in The Journal of biological chemistry 2014
Show all 3 Pubmed References
deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Proteins)- and NOTCH1 (show NOTCH1 Proteins)-regulated genes, including the MYB (show MYB Proteins) and MYC oncogenes, respectively.
B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3beta inhibition
High Myc expression is associated with hepatocarcinogenesis.
Myc-high embryonic stem cells (ESCs (show NR2E3 Proteins)) approach the naive pluripotency state, whereas Myc-low ESCs (show NR2E3 Proteins) are closer to the differentiation-primed state.
Authors here report the first MBG3 model from embryonic cerebellar cells by Myc activation and loss of Trp53 (show TP53 Proteins) function using in utero electroporation (EP)-based in vivo gene transfer combined to a Cre/LoxP-mediated technology.
by controlling both nanodomain decompaction and PolII promoter escape Myc stands as a master regulator of transcriptome amplification during B cell activation (show BLNK Proteins).
these results indicate that PIAS1 (show PIAS1 Proteins) is a positive regulator of MYC.
this study shows that that deletion of Sox2 (show SOX2 Proteins) increases the frequency of IgH:c-Myc translocations
findings highlight a MYC/ERRalpha (show ESRRA Proteins) pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha (show ESRRA Proteins) axis to drive metabolic reprogramming during osteoclast differentiation
KrasG12D-driven proliferation of pancreatic ductal epithelial cells (PDECs) depends on an EGFR (show EGFR Proteins) signaling loop engaging the oncogenic transcription factor c-MYC.
Apoptosis was also observed with myca expression; introduction of homozygous tp53 (show TP53 Proteins)(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.
MYC down-regulation induces mitochondrial apoptosis in T lymphoblasts.
MYC positively regulates RUNX3 (show RUNX3 Proteins) transcription in NKTL cell lines. MYC interacts with RUNX3 (show RUNX3 Proteins). Potential binding sites for MYC were identified in the RUNX3 (show RUNX3 Proteins) enhancer region. MYC-inhibitor JQ1 caused significant downregulation of MYC and RUNX3 (show RUNX3 Proteins), leading to apoptosis in NKTL cells. MYC may be an important upstream driver of RUNX3 (show RUNX3 Proteins) upregulation.
High myc expression is associated with lung cancer.
MYC/BCL2 (show BCL2 Proteins) co-expression is associated with a poorer prognosis and is independent of cell-of-origin classification in diffuse large B-cell lymphoma of the CNS.
Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line
MYC gene copies, centromere status and PI3K (show PIK3CA Proteins) activation may adversely impact trastuzumab treated metastatic breast cancer patient outcome and seem worthy validating in larger series.
ZNF121 (show ZNF121 Proteins) as a MYC-interacting protein with functional effects on MYC and cell proliferation
Mechanistic evidence indicates that MYC promotes recruitment of RNA methyltransferase (RNMT) to Wnt (show WNT2 Proteins) signaling gene promoters by enhancing phosphorylation of serine 5 on the RNA polymerase II carboxy-terminal domain, mediated in part through an interaction between the TIP60 (show KAT5 Proteins) acetyltransferase complex and TFIIH (show GTF2H1 Proteins).
Overexpression of c-Myc in AA derived MDA-MB-468 (Myc/MDA-468) cells resulted in a significant increase in CSCs and with minimal changes in epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) compared to the control group
Expression of far upstream element-binding protein 1 (show FUBP1 Proteins) correlates with c-Myc expression in sacral chordomas and is associated with tumor progression and poor prognosis
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
v-myc myelocytomatosis viral oncogene homolog
, Avian myelocytomatosis viral (v-myc) oncogene homolog
, myc proto-oncogene protein
, myelocytomatosis viral oncogene homolog
, proto-oncogene c-Myc
, transcription factor p64
, v-myc avian myelocytomatosis viral oncogene homolog
, c-myc proto-oncogene
, cellular myelocytomatosis oncogene
, transcriptional regulator Myc-A
, avian myelocytomatosis viral oncogene homolog
, class E basic helix-loop-helix protein 39
, myc-related translation/localization regulatory factor
, avian myelocytomatosis viral (v-myc) oncogene homolog
, Proto-oncogene c-Myc
, Transcription factor p64
, Myc proto-oncogene protein