Browse our E2F1 Proteins (E2F1)

Full name:
E2F Transcription Factor 1 Proteins (E2F1)
On are 7 E2F Transcription Factor 1 (E2F1) Proteins from 5 different suppliers available. Additionally we are shipping E2F1 Antibodies (377) and E2F1 Kits (18) and many more products for this protein. A total of 430 E2F1 products are currently listed.
ATE2FB, CG6376, dE2f, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, e2f, E2F-1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2F
list all proteins Gene Name GeneID UniProt
E2F1 1869 Q01094
E2F1 13555 Q61501
E2F1 399489  

Show all synonyms

E2F1 Proteins (E2F1) by Origin

Select your origin of interest

Top referenced E2F1 Proteins

  1. Human E2F1 Protein expressed in HEK-293 Cells - ABIN2719894 : Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. in Nature communications 2015 (PubMed)

More Proteins for E2F1 Interaction Partners

Fruit Fly (Drosophila melanogaster) E2F Transcription Factor 1 (E2F1) interaction partners

  1. specific alternate transcripts of activator E2F (show E2F2 Proteins), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor

  2. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.

  3. Mechanistically, miR (show MYLIP Proteins)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Proteins) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Proteins)-998 since dCbl phenocopies the effects of miR (show MYLIP Proteins)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Proteins) mutants

  4. also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter

  5. Results show that regulation of e2f1 and PCNA (show PCNA Proteins) by DREF (show ZBED1 Proteins) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  6. Loss of dE2F compromises mitochondrial function.

  7. Data propose that the interaction between ORC5 (show ORC5 Proteins) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.

  8. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1

  9. Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.

  10. endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 Proteins) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1

Human E2F Transcription Factor 1 (E2F1) interaction partners

  1. E2F transcription factor 1 (E2F1) downregulated micrRNA miR (show MLXIP Proteins)-519d directly and miR (show MLXIP Proteins)-519d downregulated Ras homolog gene family member C (RhoC (show RHOC Proteins)) directly.

  2. REVIEW: the data available so far indicate that the proliferative and apoptotic functions of E2F1 in Hepatocellular carcinoma (HCC (show FAM126A Proteins)) may coexist but the proliferative effect seems to be more pronounced than the apoptotic one

  3. our results established the significance of activating the KLF6 (show KLF6 Proteins)-E2F1 axis in aggressive primary metastatic clear cell renal cell carcinoma (show MOK Proteins)

  4. High E2F1 expression is associated with glioma.

  5. H19 (show NCKAP1 Proteins) is overexpressed and plays oncogenic role in PDAC through promoting cancer cell proliferation via the upregulation of E2F-1.

  6. E2F1 was significantly increased during Oral Tongue Carcinoma Metastasis.

  7. High E2F1 expression is associated with decreased radiosensitivity in nasopharyngeal carcinoma .

  8. nicotine-mediated induction of alpha7 nAChR (show CHRNA7 Proteins) was reduced when E2F1 was depleted and in contrast elevated when STAT1 (show STAT1 Proteins) was depleted by siRNAs.

  9. role for E2F1 and TFDP1 (show TFDP1 Proteins) in the transcriptional regulation of PITX1 (show PITX1 Proteins) in articular chondrocytes

  10. E2F1 forms a protein complex with EBNA3C and E2F6 (show E2F6 Proteins), and EBNA3C competes with E2F1 for E2F6 (show E2F6 Proteins) binding. E2F6 (show E2F6 Proteins) is also recruited by EBNA3C to the E2F1 promoter, which is critical for EBNA3C-mediated cell proliferation.

Mouse (Murine) E2F Transcription Factor 1 (E2F1) interaction partners

  1. E2F1 hinders skin wound healing by suppressing VEGF (show VEGFA Proteins) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.

  2. systems-level control of cell cycle arrest by pRB (show PGR Proteins)-E2F and p27 (show CDKN1B Proteins)-CDK (show CDK4 Proteins) regulation, is reported.

  3. TERT (show TERT Proteins) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.

  4. inhibition of PDK4 (show PDK4 Proteins) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Proteins), cyclin A2 (show CCNA2 Proteins), and E2F1 proteins.

  5. Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Proteins) and CD73 via E2F-1 and CREB (show CREB1 Proteins).

  6. Expression of Kv10.1 (show KCNG3 Proteins) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.

  7. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.

  8. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 and Sp1 (show SP1 Proteins), and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

  9. Protease Omi (show HTRA2 Proteins) facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma (show ARHGEF16 Proteins) cells; E2F1 is a substrate of Omi (show HTRA2 Proteins).

  10. accumulating E2f1 progressively recruits a Pontin/Reptin (show RUVBL2 Proteins) complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response.

Xenopus laevis E2F Transcription Factor 1 (E2F1) interaction partners

  1. Xphb1 represses E2F1 activity.

Arabidopsis thaliana E2F Transcription Factor 1 (E2F1) interaction partners

  1. SIM (show SIM2 Proteins) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.

  2. S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.

  3. The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.

  4. The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.

  5. Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.

  6. AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.

E2F1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Alternative names and synonyms associated with E2F1

  • E2F transcription factor (E2f)
  • E2F transcription factor 1 (E2F1)
  • E2F transcription factor 1 (E2f1)
  • E2F transcription factor 1 (e2f1)
  • ATE2FB protein
  • CG6376 protein
  • dE2f protein
  • de2f1 protein
  • def21 protein
  • DmE2F-1 protein
  • Dmel\\CG6376 protein
  • Dp protein
  • drosE2F1 protein
  • DRTF1/E2F protein
  • E(Sev-CycE)3A protein
  • E(var)3-93E protein
  • E(var)3-95E protein
  • E(var)93E protein
  • e2f protein
  • E2F-1 protein
  • e2f1 protein
  • E2FB protein
  • E2F transcription factor 1 protein
  • Evar(3)164 protein
  • l(3)07172 protein
  • l(3)j3B1 protein
  • l(3)j3C2 protein
  • l(3)rM729 protein
  • mKIAA4009 protein
  • RBAP1 protein
  • RBBP3 protein
  • RBP3 protein
  • xE2F protein

Protein level used designations for E2F1

CG6376-PA , CG6376-PB , CG6376-PC , CG6376-PD , E2-promoter binding factor , E2f-PA , E2f-PB , E2f-PC , E2f-PD , PBR3 , PRB-binding protein E2F-1 , RBAP-1 , RBBP-3 , retinoblastoma-associated protein 1 , retinoblastoma-binding protein 3 , transcription factor E2F1 , E2F-1 transcription factor , E2F-1

42550 Drosophila melanogaster
100069192 Equus caballus
1869 Homo sapiens
13555 Mus musculus
485839 Canis lupus familiaris
535369 Bos taurus
458184 Pan troglodytes
100036852 Xenopus laevis
396142 Gallus gallus
399489 Rattus norvegicus
100729531 Cavia porcellus
832283 Arabidopsis thaliana
Selected quality suppliers for E2F1 Proteins (E2F1)
Did you look for something else?