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Browse our E2F1 Proteins (E2F1)

Full name:
E2F Transcription Factor 1 Proteins (E2F1)
On www.antibodies-online.com are 7 E2F Transcription Factor 1 (E2F1) Proteins from 5 different suppliers available. Additionally we are shipping E2F1 Antibodies (360) and E2F1 Kits (18) and many more products for this protein. A total of 413 E2F1 products are currently listed.
Synonyms:
ATE2FB, CG6376, dE2f, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, e2f, E2F-1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2F
list all proteins Gene Name GeneID UniProt
E2F1 1869 Q01094
E2F1 13555 Q61501
E2F1 399489  

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E2F1 Proteins (E2F1) by Origin

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Fruit Fly (Drosophila melanogaster) E2F Transcription Factor 1 (E2F1) interaction partners

  1. specific alternate transcripts of activator E2F (show E2F2 Proteins), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor

  2. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.

  3. Mechanistically, miR (show MYLIP Proteins)-998 operates by repressing dCbl, a negative regulator of EGFR (show EGFR Proteins) signaling. Significantly, dCbl is a critical target of miR (show MYLIP Proteins)-998 since dCbl phenocopies the effects of miR (show MYLIP Proteins)-998 on dE2f1-dependent apoptosis in rbf (show ATP5I Proteins) mutants

  4. also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter

  5. Results show that regulation of e2f1 and PCNA (show PCNA Proteins) by DREF (show ZBED1 Proteins) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  6. Loss of dE2F compromises mitochondrial function.

  7. Data propose that the interaction between ORC5 (show ORC5 Proteins) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.

  8. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1

  9. Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.

  10. endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (show CCNE1 Proteins) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1

Human E2F Transcription Factor 1 (E2F1) interaction partners

  1. results suggested the existence of E2F1-miR (show MLXIP Proteins)-34c-SCF (show KITLG Proteins) negative feedback loop which was interrupted by the hyper-methylation of miR (show MLXIP Proteins)-34c promoter in CRC (show CALR Proteins) cells and increased cell proliferation.

  2. Activation of EZH2 (show EZH2 Proteins) and SUZ12 (show SUZ12 Proteins) Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer

  3. AR activity was inversely associated with cell proliferation, whereas the expression of Fa complex genes was correlated with elevated cell cycle progression, expression of the E2F transcription factor 1 (E2F1) and loss of RB1 (show RB1 Proteins).

  4. gene amplification, p53 (show TP53 Proteins) and Rb disruption, and E2F1 activation drive FOXM1 (show FOXM1 Proteins) expression in epithelial ovarian cancer, and FOXM1 (show FOXM1 Proteins) promotes cell cycle progression in cell models

  5. the present findings support the conclusion that the E2F1 transcription factor regulates the expression of ADAM12 (show ADAM12 Proteins) by binding differential cis (show CISH Proteins)-acting elements.

  6. In this review, the general structure and function of E2Fs as well as the role for E2Fs in the development of HCC (show FAM126A Proteins) and liver disease is evaluated.

  7. HER2 (show ERBB2 Proteins) signaling promotes breast cancer cell proliferation through regulation of E2F1-driven DNA metabolism.

  8. We suggest that MNNG-stimulated ATR (show ANTXR1 Proteins)/CHK1 (show CHEK1 Proteins) signaling stabilizes E2F3 by S124 phosphorylation, and then E2F3 together with NFY co-transactivate RRM2 (show RRM2 Proteins) expression for DNA repair.

  9. TGFbeta (show TGFB1 Proteins) induces autophagy through the pRb (show RB1 Proteins)/E2F1 pathway and transcriptional activation of autophagy-related genes

  10. demonstrate that E2F1 regulates lipid synthesis and glycolysis and thus contributes to the development of liver pathology

Mouse (Murine) E2F Transcription Factor 1 (E2F1) interaction partners

  1. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.

  2. In the initial stage of myocyte differentiation, transcription of the YB-1 (show YBX1 Proteins) gene was regulated by E2F1 and Sp1 (show SP1 Proteins), and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).

  3. Protease Omi (show HTRA2 Proteins) facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma (show ARHGEF16 Proteins) cells; E2F1 is a substrate of Omi (show HTRA2 Proteins).

  4. accumulating E2f1 progressively recruits a Pontin/Reptin (show RUVBL2 Proteins) complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response.

  5. A role for E2F1 and E2F2 (show E2F2 Proteins) as suppressors of replicative stress in differentiating cells, and the existence of a robust E2F-p53 (show TP53 Proteins) regulatory axis in tissue homeostasis enabling and tumorigenesis preventing is shown.

  6. E2F1 promotes apoptosis of spermatogonia during the first wave of spermatogenesis, is involved in the maintenance of the spermatogonial stem cell pool in the adult and inhibits apoptosis of the meiotic germ cells.

  7. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B (show CDKN1B Proteins)-RB1 (show RB1 Proteins)-E2F1 (cyclin-dependent kinase inhibitor 1B (show CDKN1B Proteins)-retinoblastoma 1 (show RB1 Proteins)-E2F1) pathway is essential for SSC (show CYP11A1 Proteins) (spermatogonial stem cell) self-renewal/protection against genomic damage.

  8. Conditional knockout of Poh1 (show PSMD14 Proteins) alleles results in reduced E2F1 expression in primary mouse liver cells.

  9. E2F1 negatively regulates both Ogt (show OGT Proteins) and Mgea5 (show MGEA5 Proteins) expression in an Rb1 (show RB1 Proteins) protein-dependent manner.

  10. Interplay between E2F1, miR421 and Pink1 (show PINK1 Proteins) regulates mitochondrial morphology and cardiomyocyte death. E2F1 activates miR421 expression. E2F1 knockdown suppresses mitochondrial fragmentation, apoptosis and myocardial infarction by reducing miR421 levels.

Xenopus laevis E2F Transcription Factor 1 (E2F1) interaction partners

  1. Xphb1 represses E2F1 activity.

Arabidopsis thaliana E2F Transcription Factor 1 (E2F1) interaction partners

  1. SIM (show SIM2 Proteins) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.

  2. S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.

  3. The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.

  4. The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.

  5. Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.

  6. AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.

E2F1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Alternative names and synonyms associated with E2F1

  • E2F transcription factor (E2f)
  • E2F transcription factor 1 (E2F1)
  • E2F transcription factor 1 (E2f1)
  • E2F transcription factor 1 (e2f1)
  • ATE2FB protein
  • CG6376 protein
  • dE2f protein
  • de2f1 protein
  • def21 protein
  • DmE2F-1 protein
  • Dmel\\CG6376 protein
  • Dp protein
  • drosE2F1 protein
  • DRTF1/E2F protein
  • E(Sev-CycE)3A protein
  • E(var)3-93E protein
  • E(var)3-95E protein
  • E(var)93E protein
  • e2f protein
  • E2F-1 protein
  • e2f1 protein
  • E2FB protein
  • E2FB TRANSCRIPTION FACTOR protein
  • E2F TRANSCRIPTION FACTOR-1 E2F1 protein
  • E2F transcription factor 1 protein
  • Evar(3)164 protein
  • l(3)07172 protein
  • l(3)j3B1 protein
  • l(3)j3C2 protein
  • l(3)rM729 protein
  • mKIAA4009 protein
  • RBAP1 protein
  • RBBP3 protein
  • RBP3 protein
  • xE2F protein

Protein level used designations for E2F1

CG6376-PA , CG6376-PB , CG6376-PC , CG6376-PD , E2-promoter binding factor , E2f-PA , E2f-PB , E2f-PC , E2f-PD , PBR3 , PRB-binding protein E2F-1 , RBAP-1 , RBBP-3 , retinoblastoma-associated protein 1 , retinoblastoma-binding protein 3 , transcription factor E2F1 , E2F-1 transcription factor , E2F-1

GENE ID SPECIES
42550 Drosophila melanogaster
100069192 Equus caballus
1869 Homo sapiens
13555 Mus musculus
485839 Canis lupus familiaris
535369 Bos taurus
458184 Pan troglodytes
100036852 Xenopus laevis
396142 Gallus gallus
399489 Rattus norvegicus
100729531 Cavia porcellus
832283 Arabidopsis thaliana
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