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The authors propose a model for the regulation of microtubule (MT)-based transport of pigment granules in melanophores in which reversible binding of XMAP4 to MTs (show NEU2 ELISA Kits) determines the direction of MT-based pigment granule movement.
We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK (show MAPK14 ELISA Kits) pathway activation by the LPS (show IRF6 ELISA Kits) and TNF-alpha (show TNF ELISA Kits) stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability.
Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature.
Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4).
MAP4, which is a binding partner of SEPT2 (show SEPT2 ELISA Kits).
there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 (show DYNLT1 ELISA Kits) modulation, which is connected with VDAC1 (show VDAC1 ELISA Kits), and inhibition of hypoxia-induced mitochondrial permeabilization
DNAL1 (show DNAL1 ELISA Kits) and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation.
Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 (show CLASP1 ELISA Kits) are essential for maintaining spindle position and the correct cell-division axis.
Results suggest that structural features of the PJ domain of MAP4 may contribute to the formation of a radial array of microtubules in proliferating cells.
demonstrate that ectopic MAP4 promotes outgrowth of extended MTs (show TIMM8A ELISA Kits) during beta1-integrin-induced cell spreading
activity of MAP4 is downregulated by reduced free tubulin (show TUBB ELISA Kits) concentrations
A novel isoform of MAP4 organizes the paraxial microtubule array required for muscle cell differentiation.
This study suggested that The results suggest that MAP4 play roles in some neuron-specific events, such as the dynamic cytoskeletal reorganization and regulation of the microtubule-dependent long-range transport.
Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
When the MAP4 isoforms were present in an in vitro gliding assay, the five-repeat isoform but not the three- and four-repeat isoforms inhibited the movement of the microtubules in a concentration-dependent manner.
Data indicate that MAP4 binding alters the properties of the actin filaments.
the role of the MAP4 isoforms is to regulate the surface charge of microtubules
A neural cell-specific variant of MAP4 was identified; an ultrastructural study was also made.
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
microtubule-associated protein 4
, MAP 4
, microtubule associated protein 4
, microtubule-associated protein U