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Disruptive SCYL1 (show CCL13 ELISA Kits) mutations underlie a syndrome characterized by recurrent episodes of liver failure, peripheral neuropathy, cerebellar atrophy, and ataxia (show USP14 ELISA Kits).
Data identified the large GTPase (show RACGAP1 ELISA Kits) dynamin2 as an interacting protein of NTKL (show SCYL1 ELISA Kits), which might be responsible for the phenotype alterations caused by NTKL (show SCYL1 ELISA Kits) overexpression, such as cytokinesis failure, increased cell motility and abnormal of cell division.
Data reveal that Scyl1 (show CCL13 ELISA Kits) is a key organizer of a subset of the COPI machinery.
TEIF is a downstream effector in EGF (show EGF ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling.
TEIF as a novel MSP58 (show MCRS1 ELISA Kits)-interacting protein.
suggested that the interaction of SCYL1BP1 (show GORAB ELISA Kits)/Pirh2 (show RCHY1 ELISA Kits) could accelerate Pirh2 (show RCHY1 ELISA Kits) degradation through an ubiquitin-dependent pathway. SCYL1BP1 (show GORAB ELISA Kits) may function as an important tumor suppressor gene in HCC (show FAM126A ELISA Kits) development
Scyl1 (show CCL13 ELISA Kits) interacts with 58K/formiminotransferase cyclodeaminase (FTCD (show FTCD ELISA Kits)) and golgin p115 (show ARHGAP4 ELISA Kits), and is required for the maintenance of Golgi morphology
Scyl1 (show CCL13 ELISA Kits) participates in the nuclear aminoacylation-dependent tRNA export pathway.
SCYL1-BP1 (show GORAB ELISA Kits) can be ubiquitinated and degraded by Pirh2 (show RCHY1 ELISA Kits) but not by MDM2 (show MDM2 ELISA Kits), which suggests that SCYL1-BP1 (show GORAB ELISA Kits) can be regulated by Pirh2 (show RCHY1 ELISA Kits).
NTKL (show SCYL1 ELISA Kits) is involved in centrosome-related cellular functions
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.
N-terminal kinase-like protein
, SCY1-like protein 1
, coated vesicle-associated kinase of 90 kDa
, likely ortholog of mouse N-terminal kinase-like protein
, telomerase regulation-associated protein
, telomerase transcriptional element-interacting factor
, telomerase transcriptional elements-interacting factor
, teratoma-associated tyrosine kinase