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RORgammat is acetylated, and this acetylation is reciprocally regulated by the histone acetyltransferase p300 and the histone deacetylase HDAC1 (show HDAC1 ELISA Kits).
levels of p300 protein are temporally maintained in ligand-enhanced skeletal myocyte development. this maintenance of p300 protein is observed at the stage of myoblast differentiation, which coincides with an increase in Akt (show AKT1 ELISA Kits) phosphorylation.
PIAS1 (show PIAS1 ELISA Kits) enhances p300 recruitment to c-Myb (show MYB ELISA Kits)-bound sites through interaction with both proteins. In addition, the E3 activity of PIAS1 (show PIAS1 ELISA Kits) enhances further its coactivation
coactivator p300 mediates cytokine-induced hiNOS transactivation by forming a distant DNA loop between its enhancer and core promoter region
BCL6 (show BCL6 ELISA Kits) repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.
DDX24 (show DDX24 ELISA Kits) inhibits p300 mediated acetylation of p53 (show TP53 ELISA Kits).
p300 overexpression and its association with clinical factors in patients with OSCC, it is likely that p300 itself or one of its target genes plays a key role in the aggressive phenotypes of OSCC.
these data suggest that CBP/p300 (show CREBBP ELISA Kits) are promising therapeutic targets across multiple subtypes in acute myeloid leukemia (show BCL11A ELISA Kits).
Our results link FGF8 (show FGF8 ELISA Kits), c-Abl (show ABL1 ELISA Kits) and p300 in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity.
DOT1L epigenetically derepresses epithelial-mesenchymal transition transcription factors with c-Myc (show MYC ELISA Kits) and p300.
Findings indicate that E1a-binding protein (p300) is not required for the normal development or functioning of skeletal muscle.
Hdac3 (show HDAC3 ELISA Kits) cooperates with p300 (show NOTCH1 ELISA Kits) to prime and maintain oligodendrocyte identity
p300 (show NOTCH1 ELISA Kits) histone acetyltransferase (show HAT ELISA Kits) activity is critical for Wnt (show WNT2 ELISA Kits)-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate.
Data indicate that glucose-induced endothelial to mesenchymal transition in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR (show MLXIP ELISA Kits)-200b and p300 (show NOTCH1 ELISA Kits).
This study demonstrated that p300 (show NOTCH1 ELISA Kits) increase in skeletal muscle in muscle atrophy.
This study demonstrates that p300 (show NOTCH1 ELISA Kits) mediates histone acetylation of PS1 (show PSEN1 ELISA Kits) and BACE1 (show BACE ELISA Kits) in a cellular model of Alzheimer's disease.
p300 (show NOTCH1 ELISA Kits) regulates a number of critical signaling pathways that control liver functions.
p300 (show NOTCH1 ELISA Kits) conditional knockout in Treg cells leads to minimal changes in Treg functions.
on Bcl6 (show BCL6 ELISA Kits), p300 (show NOTCH1 ELISA Kits) functioned as a repressor and inhibited in conjunction with STAT5 (show STAT5A ELISA Kits) or BCL6 (show BCL6 ELISA Kits).
These results suggest that the aristolochic acid dose dependently contributed to the development of nephropathy, and HDAC1 (show HDAC1 ELISA Kits) and p300 (show NOTCH1 ELISA Kits) participate in the modulation of TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) pathway-mediated renal interstitial fibrosis.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT