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p300 Products

(E1A Binding Protein P300 (EP300))
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].

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Featured p300 Categories

p300 Antibodies

High quality antibodies with extensive validation data.

p300 ELISA Kits

Reliable ELISA kits for a wide range of species.

p300 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended p300 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (6)
Cat. No. ABIN6140193
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (1)
  • (4)
Cat. No. ABIN560748
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (6)
Cat. No. ABIN3042372
Quantity 100 μg
Datasheet Datasheet

Recommended p300 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955487
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955486
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955488
Quantity 96 tests
Datasheet Datasheet

Recommended p300 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352865
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN2669637
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (1)
  • (1)
Cat. No. ABIN2720219
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our p300 products

Latorre-Muro, Baeza, Armstrong, Hurtado-Guerrero, Corzana, Wu, Sinclair, López-Buesa, Carrodeguas, Denu: "Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions." in: Molecular cell, Vol. 71, Issue 5, pp. 718-732.e9, (2019) (PubMed).

Dhar, Zhao, Lin, Gu, Pal, Wu, Alam, Lv, Yun, Gopalakrishnan, Flores, Northcott, Rajaram, Li, Shilatifard, Sillitoe, Chen, Lee: "MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes." in: Molecular cell, Vol. 70, Issue 5, pp. 825-841.e6, (2018) (PubMed).

Xiao, Ye, Zhou, Huang, Liu, Huang, Zhu, Wu, Zhang, Cai: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).

Feng, Cao, Chen, Chu, Chu, Chakrabarti: "miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy." in: Diabetes, Vol. 65, Issue 3, pp. 768-79, (2016) (PubMed).

Lee, Huang, Chang, Huang, Hsieh, Chen, Chou, Chiang, Lai, Shiau: "Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions." in: Scientific reports, Vol. 6, pp. 29311, (2016) (PubMed).

Luo, Chen, Chen, Alkam, Wang, Semenza: "PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia." in: Oncotarget, Vol. 7, Issue 6, pp. 6379-97, (2016) (PubMed).

Martinez, Abe, Hong, Molyneux, Yarnell, Löhr, Driever, Acosta, Arcos-Burgos, Muenke: "An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility." in: Biological psychiatry, Vol. 80, Issue 12, pp. 943-954, (2016) (PubMed).

Paladino, Yue, Furuya, Acoba, Rosser, Turkson: "A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer." in: Oncotarget, Vol. 7, Issue 6, pp. 7253-67, (2016) (PubMed).

Zhang, Zhang, Xiao, Liu, Wang, Gao, Rong, Yao, Li, Xu: "The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway." in: Biochemical pharmacology, Vol. 101, pp. 100-11, (2016) (PubMed).

Aubry, Shin, Crary, Lefort, Qureshi, Lefebvre, Califano, Shelanski: "Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120352, (2015) (PubMed).

Synonyms and alternative names related to p300

E1A binding protein p300 (EP300), histone acetyltransferase p300 (LOC446056), E1A binding protein p300 (ep300), E1A binding protein p300 (Ep300), A430090G16, A730011L11, KAT3B, p300, p300 HAT, RSTS2

Protein level used designations for p300

  • histone acetyltransferase p300
  • histone acetyltransferase
  • E1A binding protein p300
  • histone acetyltransferase p300-like
  • E1A-associated protein p300
  • E1A-binding protein, 300kD
  • p300 HAT
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