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Browse our PDCD6IP Proteins (PDCD6IP)

Full name:
Programmed Cell Death 6 Interacting Protein Proteins (PDCD6IP)
On are 13 Programmed Cell Death 6 Interacting Protein (PDCD6IP) Proteins from 7 different suppliers available. Additionally we are shipping PDCD6IP Antibodies (89) and PDCD6IP Kits (4) and many more products for this protein. A total of 113 PDCD6IP products are currently listed.
2310011D08Rik, AI480459, AI480591, aip1, alix, AW544830, C76364, CG12876, DAIP1, DDBDRAFT_0167145, DDBDRAFT_0185177, DDB_0167145, DDB_0185177, Dmel\\CG12876, DRIP4, Eig2, GB11744, HP95, mKIAA1375, mKIAA1743, NORI-1, PDCD6IP, RGD1561176, wu:fb70d03, wu:fy65h02, zgc:63638
list all proteins Gene Name GeneID UniProt
PDCD6IP 69601 Q3UHC7
PDCD6IP 10015 Q8WUM4
Rat PDCD6IP PDCD6IP 501083  

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PDCD6IP Proteins (PDCD6IP) by Origin

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Top referenced PDCD6IP Proteins

  1. Human PDCD6IP Protein expressed in Escherichia coli (E. coli) - ABIN666945 : Katoh, Shibata, Hatta, Maki: CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. in Archives of biochemistry and biophysics 2003 (PubMed)
    Show all 2 references for ABIN666945

More Proteins for PDCD6IP Interaction Partners

Fruit Fly (Drosophila melanogaster) Programmed Cell Death 6 Interacting Protein (PDCD6IP) interaction partners

  1. We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.

Mouse (Murine) Programmed Cell Death 6 Interacting Protein (PDCD6IP) interaction partners

  1. DAB2IP (show DAB2IP Proteins) loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death.

  2. Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells.

  3. Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.

  4. results suggest that Dab2IP plays an important role in the migration and positioning of a subpopulation of later-born (layers II-IV) neurons, likely through the regulation of Rap1 and integrin signaling.

  5. Our data reveal that AIP1, by inhibiting VEGFR2 (show KDR Proteins)-dependent signaling in tumor niche, suppresses tumor EMT (show ITK Proteins) switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis.

  6. AIP1 was elevated in the brain of AD Tg2576 mice. Abeta1-42 treatment induced the interaction of AIP1 and ASK1 (show MAP3K5 Proteins), which led to dissociation of ASK1 (show MAP3K5 Proteins) and 14-3-3 (show YWHAQ Proteins).

  7. site-specific methylation of mDab2ip gene during cerebellar development may play a role in inclusion of exon 5, resulting in a Dab2ip (show DAB2IP Proteins) transcript variant that encodes a full pleckstrin (show PLEK Proteins) homology (PH) domain.

  8. ATG12 (show ATG12 Proteins)-ATG3 (show ATG3 Proteins) interacts with Alix to promote basal autophagic flux and late endosome function.

  9. Study showed that DAB2IP (show DAB2IP Proteins) can be functionally inactivated by physical interaction with mutant p53 (show TP53 Proteins) proteins with implications for the response of cancer cells to inflammatory cytokines.

  10. DAB2IP (show DAB2IP Proteins) is a unique intrinsic androgen receptor (show AR Proteins) modulator in normal cells, and likely can be further developed into a therapeutic agent for rpostate cancer.

Xenopus laevis Programmed Cell Death 6 Interacting Protein (PDCD6IP) interaction partners

  1. These findings establish that Xp95/Alix is phosphorylated within the proline-rich domain during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins.

Human Programmed Cell Death 6 Interacting Protein (PDCD6IP) interaction partners

  1. phosphorylation of the intramolecular interaction site in the PRD is one of the major mechanisms that activates the ESCRT function of ALIX

  2. homologous domain of human Bro1 (show HMGCR Proteins) domain-containing proteins, Alix and Brox, binds CHMP4B (show CHMP4A Proteins) but not STAM2 (show STAM2 Proteins), despite their high structural similarity

  3. Accordingly, ALIX depletion leads to furrow regression in cells with chromosome bridges, a phenotype associated with abscission checkpoint signaling failure.

  4. Findings indicate that the PDCD6IP 15bp insertion/deletion polymorphism decreases the risk of breast neoplasm in an Iranian population.

  5. The serum lever of Alzheimer's disease were decrease and the expression of ALIX strongly correlated with the Mini-Mental State Examination scores of the AD patients

  6. our findings identify heparanase (show HPSE Proteins) as a modulator of the syndecan (show SDC1 Proteins)-syntenin (show SDCBP Proteins)-ALIX pathway, fostering endosomal membrane budding and the biogenesis of exosomes by trimming the heparan sulfate chains on syndecans

  7. Our data reveal that AIP1 (show BIRC3 Proteins), by inhibiting VEGFR2 (show KDR Proteins)-dependent signaling in tumor niche, suppresses tumor EMT (show ITK Proteins) switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis.

  8. Lack of ALG-2 (show PDCD6 Proteins), ALIX or Vps4B (show vps4b Proteins) each prevents shedding, and repair of the injured cell membrane

  9. Demonstrate a previously unanticipated role of Aip1 (show BIRC3 Proteins) in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis.

  10. Alix is critically involved in multivesicular body sorting of membrane receptors in mammalian cells.

PDCD6IP Protein Profile

Protein Summary

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PDCD6IP

  • ALG-2 interacting protein X (ALiX)
  • ALG-2 interacting protein X (alxA)
  • programmed cell death 6 interacting protein (pdcd6ip)
  • programmed cell death 6 interacting protein (PDCD6IP)
  • Programmed cell death 6 interacting protein (Bm1_48390)
  • disabled 2 interacting protein (Dab2ip)
  • programmed cell death 6 interacting protein (Pdcd6ip)
  • WD repeat domain 1 (WDR1)
  • 2310011D08Rik protein
  • AI480459 protein
  • AI480591 protein
  • aip1 protein
  • alix protein
  • AW544830 protein
  • C76364 protein
  • CG12876 protein
  • DAIP1 protein
  • DDBDRAFT_0167145 protein
  • DDBDRAFT_0185177 protein
  • DDB_0167145 protein
  • DDB_0185177 protein
  • Dmel\\CG12876 protein
  • DRIP4 protein
  • Eig2 protein
  • GB11744 protein
  • HP95 protein
  • mKIAA1375 protein
  • mKIAA1743 protein
  • NORI-1 protein
  • PDCD6IP protein
  • RGD1561176 protein
  • wu:fb70d03 protein
  • wu:fy65h02 protein
  • zgc:63638 protein

Protein level used designations for PDCD6IP

ALG-2 interacting protein 1 , ALiX-PA , CG12876-PA , programmed cell death 6-interacting protein , programmed cell death 6 interacting protein , Programmed cell death 6 interacting protein , ASK-interacting protein 1 , ASK1-interacting protein 1 , DAB2-interacting protein , DOC-2/DAB-2 interactive protein , disabled 2 interacting protein long form , disabled homolog 2 interacting protein , disabled homolog 2-interacting protein , putative signal tranduction protein Xp95 , signal transduction protein Xp95 , ALG-2-interacting protein X , PDCD6-interacting protein , apoptosis-linked gene 2-interacting protein X , dopamine receptor interacting protein 4 , ALG-2-interacting protein 1 , Alg2-interacting protein 1 , Alg2-interacting protein X , E2f1-inducible protein , ALG-2 interacting protein X , WD repeat-containing protein 1 , actin-interacting protein 1

43330 Drosophila melanogaster
412662 Apis mellifera
8620152 Dictyostelium discoideum AX4
406669 Danio rerio
420725 Gallus gallus
477015 Canis lupus familiaris
496474 Xenopus (Silurana) tropicalis
6104563 Brugia malayi
100546453 Meleagris gallopavo
69601 Mus musculus
398095 Xenopus laevis
10015 Homo sapiens
18571 Mus musculus
501083 Rattus norvegicus
9948 Homo sapiens
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