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ALIX Products

(Programmed Cell Death 6 Interacting Protein (PDCD6IP))

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This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012].

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Featured ALIX Categories

ALIX Antibodies

High quality antibodies with extensive validation data.

ALIX ELISA Kits

Reliable ELISA kits for a wide range of species.

ALIX Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ALIX Antibodies

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Reactivity
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Cat. No.
Quantity
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Reactivity Human
Application IF, WB
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Cat. No. ABIN523392
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IP, WB
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Cat. No. ABIN950059
Quantity 100 μL
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Reactivity Human
Application IF, ELISA, WB
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Cat. No. ABIN564316
Quantity 100 μg
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Recommended ALIX ELISA Kits

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Reactivity
Analytical Method
Validations
Cat. No.
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Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
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Cat. No. ABIN6958805
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975742
Quantity 96 tests
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Recommended ALIX Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
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Reactivity Human
Source Insect Cells
Validations
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Cat. No. ABIN3094449
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3137504
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314432
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our ALIX products

Mariscal, Fernandez-Puente, Calamia, Abalo, Santacana, Matias-Guiu, Lopez-Lopez, Gil-Moreno, Alonso-Alconada, Abal: "Proteomic Characterization of Epithelial-Like Extracellular Vesicles in Advanced Endometrial Cancer." in: Journal of proteome research, Vol. 18, Issue 3, pp. 1043-1053, (2019) (PubMed).

Mukhamedova, Hoang, Dragoljevic, Dubrovsky, Pushkarsky, Low, Ditiatkovski, Fu, Ohkawa, Meikle, Horvath, Brichacek, Miller, Murphy, Bukrinsky, Sviridov: "Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells." in: PLoS pathogens, Vol. 15, Issue 7, pp. e1007907, (2019) (PubMed).

Bei, Xu, Lv, Yu, Xu, Che, Das, Tigges, Toxavidis, Ghiran, Shah, Li, Zhang, Das, Xiao: "Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury." in: Basic research in cardiology, Vol. 112, Issue 4, pp. 38, (2018) (PubMed).

Haga, Yan, Takahashi, Matsuda, Patel: "Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice." in: Stem cells translational medicine, Vol. 6, Issue 4, pp. 1262-1272, (2017) (PubMed).

Xu, Qin, An, Tang, Huang, Zheng: "MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method." in: The Prostate, Vol. 77, Issue 10, pp. 1167-1175, (2017) (PubMed).

Kowal, Arras, Colombo, Jouve, Morath, Primdal-Bengtson, Dingli, Loew, Tkach, Théry: "Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 8, pp. E968-77, (2016) (PubMed).

Takahashi, Kojima, Zhang, Sasaki, Ito, Suzuki, Kawasaki, Wakatsuki, Takahara, Shibata, Maki: "Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2." in: International journal of molecular sciences, Vol. 16, Issue 2, pp. 3677-99, (2015) (PubMed).

Zhao, Wu, Duan, Ma, Shen, Wei, Cui, Zhang, Xie, Liu: "Quantitative proteomic analysis of exosome protein content changes induced by hepatitis B virus in Huh-7 cells using SILAC labeling and LC-MS/MS." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5391-402, (2015) (PubMed).

Inuzuka, Inokawa, Chen, Kizu, Narita, Shibata, Maki: "ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by exosomal pathway and taken up by recipient cultured cells." in: Bioscience reports, (2013) (PubMed).

Liu, Hsu, Chen, Yang, Carraway, Isseroff, Liu: "Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration." in: The Journal of investigative dermatology, Vol. 132, Issue 12, pp. 2828-37, (2012) (PubMed).

Synonyms and alternative names related to ALIX

ALG-2 interacting protein X (alxA), programmed cell death 6 interacting protein (PDCD6IP), programmed cell death 6 interacting protein (Pdcd6ip), ALG-2 interacting protein X (ALiX), programmed cell death 6-interacting protein (LOC412662), programmed cell death 6 interacting protein (pdcd6ip), Programmed cell death 6 interacting protein (Bm1_48390), programmed cell death 6 interacting protein L homeolog (pdcd6ip.L), AI480591, AIP1, Aip1, aip1, ALIX, Alix, alix, AW544830, C76364, CG12876, DAIP1, DDBDRAFT_0167145, DDBDRAFT_0185177, DDB_0167145, DDB_0185177, Dmel\\CG12876, DRIP4, drip4, Eig2, GB11744, HP95, hp95, mKIAA1375, PDCD6IP, RGD1561176, wu:fb70d03, wu:fy65h02, zgc:63638

Protein level used designations for ALIX

  • ALG-2 interacting protein 1
  • ALG-2-interacting protein X
  • PDCD6-interacting protein
  • apoptosis-linked gene 2-interacting protein X
  • dopamine receptor interacting protein 4
  • programmed cell death 6-interacting protein
  • ALG-2-interacting protein 1
  • Alg2-interacting protein 1
  • Alg2-interacting protein X
  • E2f1-inducible protein
  • ALiX-PA
  • CG12876-PA
  • ALG-2 interacting protein X
  • programmed cell death 6 interacting protein
  • Programmed cell death 6 interacting protein
  • putative signal tranduction protein Xp95
  • signal transduction protein Xp95
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