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Browse our anti-PML (PML) Antibodies

Full name:
anti-Promyelocytic Leukemia Antibodies (PML)
On www.antibodies-online.com are 121 Promyelocytic Leukemia (PML) Antibodies from 26 different suppliers available. Additionally we are shipping PML Proteins (8) and PML Kits (6) and many more products for this protein. A total of 144 PML products are currently listed.
Synonyms:
1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, Trim19
list all antibodies Gene Name GeneID UniProt
PML 5371 P29590
PML 18854 Q60953
PML 315713  

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All available anti-PML Antibodies

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Top referenced anti-PML Antibodies

  1. Human Monoclonal PML Primary Antibody for IF, WB - ABIN394032 : Vincenzi, Perrone, Santini, Grosso, Silletta, Frezza, Rossi, Russo, Rabitti, Gebbia, Badalamenti, Casali, Muda, Dei Tos, Tonini: PML down-regulation in soft tissue sarcomas. in Journal of cellular physiology 2010 (PubMed)
    Show all 5 references for ABIN394032

  2. Human Polyclonal PML Primary Antibody for EIA, IHC (p) - ABIN357734 : Kawai, Akira, Reed: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for ABIN357734

  3. Mouse (Murine) Monoclonal PML Primary Antibody for IF, IP - ABIN567791 : Sone, Hayashi, Tarui, Agata, Takeichi, Nakagawa: The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. in Journal of cell science 2007 (PubMed)
    Show all 3 references for ABIN567791

  4. Human Polyclonal PML Primary Antibody for ELISA, WB - ABIN1583526 : Kolegraff, Nava, Helms, Parkos, Nusrat: Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling. in Molecular biology of the cell 2011 (PubMed)
    Show all 2 references for ABIN1583526

  5. Human Polyclonal PML Primary Antibody for FACS, IF - ABIN389073 : Puccetti, Beissert, Güller, Li, Hoelzer, Ottmann, Ruthardt: Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. in Oncogene 2003 (PubMed)
    Show all 2 references for ABIN389073

  6. Human Polyclonal PML Primary Antibody for WB - ABIN2778427 : Eun, Lee, Hong, Kim, Lee, Kim, Sun, Kim: Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against PML Interaction Partners

Human Promyelocytic Leukemia (PML) interaction partners

  1. Our work provides a novel view of the physiologic function of PML, which participates in telomeres surveillance in normal cells. Our data further imply that a diminished PML function may contribute to cell senescence, genomic instability and tumorigenesis

  2. Authors demonstrate leukemogenicity of PAX5 (show PAX5 Antibodies)-PML by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk (show BLNK Antibodies)) is repressed by PAX5 (show PAX5 Antibodies)-PML in leukemia cells; enforced expression of Blnk (show BLNK Antibodies) increases survival despite introduction of PAX5 (show PAX5 Antibodies)-PML.

  3. Mutations affect both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia.

  4. Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARalpha (show RARA Antibodies) protein degradation in acute promyelocytic leukemia.

  5. Novel insight into the functional difference of acquired mutations of PML-RARA (show RARA Antibodies) both in vitro and in the clinical setting.

  6. Authors performed mutational analysis to define a PML interaction motif within the E1B (show BCKDHB Antibodies)-55K polypeptide. Results showed that E1B (show BCKDHB Antibodies)-55K/PML binding is not required for p53 (show TP53 Antibodies), Mre11 (show MRE11A Antibodies) and Daxx (show DAXX Antibodies) interaction.

  7. These data suggest that targeting PML by human herpesvirus 5 IE1 represents a strategy to antagonize both intrinsic and innate immune mechanisms.

  8. The results corroborated that PML-II plays a critical role in generating nuclear Lipid droplets in specific cell types.

  9. Studies of the dynamics of the response of PML nuclear body components and IFI16 (show IFI16 Antibodies) to invading herpes simplex virus 1 genomes demonstrated that human Daxx (hDaxx (show DAXX Antibodies)) and IFI16 (show IFI16 Antibodies) respond more rapidly than PML.

  10. PML is upregulated in obesity and liver steatosis.

Mouse (Murine) Promyelocytic Leukemia (PML) interaction partners

  1. both the PML-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL (show FASL Antibodies)) required DNMT3A (show DNMT3A Antibodies)

  2. PML IV enhances global SUMO-1 (show SUMO1 Antibodies) conjugation, particularly that of p53 (show TP53 Antibodies), resulting in p53 (show TP53 Antibodies) stabilization and activation.

  3. our findings challenge the predominant model in the field and we propose that PML/RARA (show RARA Antibodies) initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

  4. DNA-binding-defective PML/RARA (show RARA Antibodies) mutants could not repress the transcription of retinoic acid regulated genes.

  5. A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 (show NFE2L2 Antibodies) activity and identified PML as an indispensable mediator of SFN (show SFN Antibodies) activity.

  6. pRB (show PGR Antibodies) can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB (show PGR Antibodies) to establish heterochromatin and create a permanent cell cycle arrest.

  7. Data suggest that acute promyelocytic leukemia (APL (show FASL Antibodies)) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha (show RARA Antibodies) fusion oncoprotein PML/RARA (show RARA Antibodies)-bound promoters.

  8. Our results add PML/TRIM19 to the growing list of TRIM (show TRAT1 Antibodies) proteins implicated in both intrinsic and innate immunity.

  9. Oxidized PML spherical meshes recruit UBC9 (show UBE2I Antibodies) and enhances PML sumoylation.

  10. ORF61 encoded the viral ribonucleotide reductase large subunit (show RRM1 Antibodies) is a second PML-modifying protein.

PML Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PML

  • promyelocytic leukemia (PML) antibody
  • promyelocytic leukemia (Pml) antibody
  • 1200009E24Rik antibody
  • AI661194 antibody
  • MYL antibody
  • PML antibody
  • PP8675 antibody
  • RGD1562602 antibody
  • RNF71 antibody
  • Trim19 antibody

Protein level used designations for PML

promyelocytic leukemia , probable transcription factor PML , promyelocytic leukemia protein , protein PML , probable transcription factor PML-like , RING finger protein 71 , promyelocytic leukemia, inducer of , tripartite motif protein TRIM19 , tripartite motif-containing protein 19

GENE ID SPECIES
415302 Gallus gallus
415304 Gallus gallus
453736 Pan troglodytes
700379 Macaca mulatta
100138545 Bos taurus
100388843 Callithrix jacchus
100607016 Nomascus leucogenys
5371 Homo sapiens
18854 Mus musculus
315713 Rattus norvegicus
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