Browse our anti-PML (PML) Antibodies

On www.antibodies-online.com are 156 Promyelocytic Leukemia (PML) Antibodies from 29 different suppliers available. Additionally we are shipping PML Proteins (8) and PML Kits (7) and many more products for this protein. A total of 180 PML products are currently listed.
Synonyms:
1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, Trim19
list all antibodies Gene Name GeneID UniProt
PML 5371 P29590
PML 18854 Q60953
PML 315713  

Most Popular Reactivities for anti-PML (PML) Antibodies

anti-Human PML Antibodies:

anti-Mouse (Murine) PML Antibodies:

anti-Rat (Rattus) PML Antibodies:

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More Antibodies against PML Interaction Partners

Human Promyelocytic Leukemia (PML) interaction partners

  1. Sumoylation of PML with SUMO2 (show SUMO2 Antibodies) by UBC9/UBE2I (show UBE2I Antibodies) can lead to formation of polymeric SUMO chains. Data suggest that coordination of growing poly-SUMO chain with "back side" binding site on UBC9/UBE2I (show UBE2I Antibodies) appears to be required for SUMO chain elongation on PML. (PML = promyelocytic leukemia protein; SUMO2 (show SUMO2 Antibodies) = small ubiquitin-like modifier 2 (show SUMO2 Antibodies); UBC9/UBE2I (show UBE2I Antibodies) = ubiquitin-conjugating enzyme (show Ube2t Antibodies) UBC9/UBE2I (show UBE2I Antibodies))

  2. Data show that the cytoplasmic localization of promyelocytic leukaemia (PML) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1 (show XPO1 Antibodies))-dependent manner.

  3. this study, we first observed that PML-positive intranuclear aggregates also appeared in controls and were not specific for the Neuronal Intranuclear Hyaline Inclusion Disease cases.

  4. TRIB3 (show TRIB3 Antibodies) promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha (show RARA Antibodies) and inhibition of p53 (show TP53 Antibodies)-mediated senescence.

  5. Data suggest that the binding of Z-10 to RXRalpha (show RXRA Antibodies) inhibited the interaction of RXRalpha (show RXRA Antibodies) with PML-RARalpha (show RARA Antibodies), leading to Z-10's selective induction of PML-RARalpha (show RARA Antibodies) degradation.

  6. PML protein prevents the loss of HPV genome following infection implying that the host cell may be able to recognize chromatinized HPV genome or the associated capsid proteins.

  7. findings demonstrate that the PML protein, which mediates an intrinsic immune response against human cytomegalovirus, specifically serves as an E3 ligase for SUMO modification of IE1p72.

  8. During infection, PML undergoes oxidation-mediated multimerization, associates with the nuclear matrix, and becomes de-SUMOylated due to the pore-forming activity of the Listeria toxin listeriolysin O (LLO).

  9. Data suggest PML (promyelocytic leukemia protein) positively regulates STAT1 (show STAT1 Antibodies) and STAT2 (show STAT2 Antibodies) isgylation, a ubiquitination-like protein modification; PML exhibits potent angiostatic activity, doing so in part by forming a positive feedforward loop with STAT1 (show STAT1 Antibodies)/2 and a negative feedback loop with STAT3 (show STAT3 Antibodies). (STAT (show STAT1 Antibodies) = signal transducer and activator of transcription (show STAT1 Antibodies))

  10. PML(nuclear localization signal -) was detected in primary acute promyelocytic leukemia (APL (show FASL Antibodies)), but not non-APL (show FASL Antibodies) cells. PML was localized to the nucleus, interacted with importin alpha (show KPNA4 Antibodies) in vivo, and co-localized in the PML nuclear bodies. PML(NLS (show ALDH1A2 Antibodies)-) was primarily localized in the cytoplasm and the interaction with importin alpha (show KPNA4 Antibodies) was lost

Mouse (Murine) Promyelocytic Leukemia (PML) interaction partners

  1. The data demonstrate a dual role of PML in protection and recovery after brain injury.

  2. This study designates PML protein and PML-NBs (show NLRP2 Antibodies) to be major cellular components involved in the control of Herpes simplex virus 1 (HSV-1) latency, probably during the entire life of an individual.

  3. Study found that Promyelocytic leukemia protein (PML) is broadly expressed across the gray matter, with the highest levels in the cerebral and cerebellar cortices. PML bodies are broadly involved in activity-dependent nuclear phenomena in adult neurons

  4. These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.

  5. PML contributes to the intrinsic restriction of HIV-1 infections in a cell type-dependent manner.

  6. both the PML-RARA (show RARA Antibodies)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL (show FASL Antibodies)) required DNMT3A (show DNMT3A Antibodies)

  7. PML IV enhances global SUMO-1 (show SUMO1 Antibodies) conjugation, particularly that of p53 (show TP53 Antibodies), resulting in p53 (show TP53 Antibodies) stabilization and activation.

  8. our findings challenge the predominant model in the field and we propose that PML/RARA (show RARA Antibodies) initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

  9. DNA-binding-defective PML/RARA (show RARA Antibodies) mutants could not repress the transcription of retinoic acid regulated genes.

  10. A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 (show NFE2L2 Antibodies) activity and identified PML as an indispensable mediator of SFN (show SFN Antibodies) activity.

PML Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PML

  • promyelocytic leukemia (PML) antibody
  • promyelocytic leukemia (Pml) antibody
  • 1200009E24Rik antibody
  • AI661194 antibody
  • MYL antibody
  • PML antibody
  • PP8675 antibody
  • RGD1562602 antibody
  • RNF71 antibody
  • Trim19 antibody

Protein level used designations for PML

promyelocytic leukemia , probable transcription factor PML , promyelocytic leukemia protein , protein PML , probable transcription factor PML-like , RING finger protein 71 , promyelocytic leukemia, inducer of , tripartite motif protein TRIM19 , tripartite motif-containing protein 19

GENE ID SPECIES
415302 Gallus gallus
415304 Gallus gallus
453736 Pan troglodytes
700379 Macaca mulatta
100138545 Bos taurus
100388843 Callithrix jacchus
100607016 Nomascus leucogenys
5371 Homo sapiens
18854 Mus musculus
315713 Rattus norvegicus
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