Browse our PML Proteins (PML)

Full name:
Promyelocytic Leukemia Proteins (PML)
On are 8 Promyelocytic Leukemia (PML) Proteins from 5 different suppliers available. Additionally we are shipping PML Antibodies (136) and PML Kits (7) and many more products for this protein. A total of 160 PML products are currently listed.
1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, Trim19
list all proteins Gene Name GeneID UniProt
PML 5371 P29590
PML 18854 Q60953
Rat PML PML 315713  

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PML Proteins (PML) by Origin

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More Proteins for PML Interaction Partners

Human Promyelocytic Leukemia (PML) interaction partners

  1. TRIB3 (show TRIB3 Proteins) promotes acute promyelocytic leukemia progression through stabilization of the oncoprotein PML-RARalpha (show RARA Proteins) and inhibition of p53 (show TP53 Proteins)-mediated senescence.

  2. Data suggest that the binding of Z-10 to RXRalpha (show RXRA Proteins) inhibited the interaction of RXRalpha (show RXRA Proteins) with PML-RARalpha (show RARA Proteins), leading to Z-10's selective induction of PML-RARalpha (show RARA Proteins) degradation.

  3. PML protein prevents the loss of HPV genome following infection implying that the host cell may be able to recognize chromatinized HPV genome or the associated capsid proteins.

  4. findings demonstrate that the PML protein, which mediates an intrinsic immune response against human cytomegalovirus, specifically serves as an E3 ligase for SUMO modification of IE1p72.

  5. During infection, PML undergoes oxidation-mediated multimerization, associates with the nuclear matrix, and becomes de-SUMOylated due to the pore-forming activity of the Listeria toxin listeriolysin O (LLO).

  6. Data suggest PML (promyelocytic leukemia protein) positively regulates STAT1 (show STAT1 Proteins) and STAT2 (show STAT2 Proteins) isgylation, a ubiquitination-like protein modification; PML exhibits potent angiostatic activity, doing so in part by forming a positive feedforward loop with STAT1 (show STAT1 Proteins)/2 and a negative feedback loop with STAT3 (show STAT3 Proteins). (STAT (show STAT1 Proteins) = signal transducer and activator of transcription (show STAT1 Proteins))

  7. PML(nuclear localization signal -) was detected in primary acute promyelocytic leukemia (APL (show FASL Proteins)), but not non-APL (show FASL Proteins) cells. PML was localized to the nucleus, interacted with importin alpha (show KPNA4 Proteins) in vivo, and co-localized in the PML nuclear bodies. PML(NLS (show ALDH1A2 Proteins)-) was primarily localized in the cytoplasm and the interaction with importin alpha (show KPNA4 Proteins) was lost

  8. These data suggest that CACUL1 is a novel regulator that negatively controls p53 (show TP53 Proteins) activity through the regulation of PML SUMOylation.

  9. An HSV-1 protein, ICP0, can recognize individual host factors and target them differently for destruction. We identified elements that are important for the ICP0 E3 ubiquitin ligase (show MUL1 Proteins) to differentially recognize two of its substrates, isoforms PML I and PML II.

  10. In line with these observations, rhesus monkey rhadinovirus infection resulted in rapid degradation of SP100 (show SP100 Proteins), followed by degradation of PML and the loss of ND10 structures, whereas the protein levels of ATRX (show ATRX Proteins) and DAXX (show DAXX Proteins) remained constant.

Mouse (Murine) Promyelocytic Leukemia (PML) interaction partners

  1. These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.

  2. PML contributes to the intrinsic restriction of HIV-1 infections in a cell type-dependent manner.

  3. both the PML-RARA (show RARA Proteins)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL (show FASL Proteins)) required DNMT3A (show DNMT3A Proteins)

  4. PML IV enhances global SUMO-1 (show SUMO1 Proteins) conjugation, particularly that of p53 (show TP53 Proteins), resulting in p53 (show TP53 Proteins) stabilization and activation.

  5. our findings challenge the predominant model in the field and we propose that PML/RARA (show RARA Proteins) initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

  6. DNA-binding-defective PML/RARA (show RARA Proteins) mutants could not repress the transcription of retinoic acid regulated genes.

  7. A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 (show NFE2L2 Proteins) activity and identified PML as an indispensable mediator of SFN (show SFN Proteins) activity.

  8. pRB (show PGR Proteins) can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB (show PGR Proteins) to establish heterochromatin and create a permanent cell cycle arrest.

  9. Data suggest that acute promyelocytic leukemia (APL (show FASL Proteins)) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha (show RARA Proteins) fusion oncoprotein PML/RARA (show RARA Proteins)-bound promoters.

  10. Our results add PML/TRIM19 to the growing list of TRIM (show TRAT1 Proteins) proteins implicated in both intrinsic and innate immunity.

PML Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PML

  • promyelocytic leukemia (PML)
  • promyelocytic leukemia (Pml)
  • 1200009E24Rik protein
  • AI661194 protein
  • MYL protein
  • PML protein
  • PP8675 protein
  • RGD1562602 protein
  • RNF71 protein
  • Trim19 protein

Protein level used designations for Promyelocytic Leukemia Proteins (PML)

promyelocytic leukemia , probable transcription factor PML , promyelocytic leukemia protein , protein PML , probable transcription factor PML-like , RING finger protein 71 , promyelocytic leukemia, inducer of , tripartite motif protein TRIM19 , tripartite motif-containing protein 19

415302 Gallus gallus
415304 Gallus gallus
453736 Pan troglodytes
700379 Macaca mulatta
100138545 Bos taurus
100388843 Callithrix jacchus
100607016 Nomascus leucogenys
5371 Homo sapiens
18854 Mus musculus
315713 Rattus norvegicus
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