You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our PML Proteins (PML)

Full name:
Promyelocytic Leukemia Proteins (PML)
On are 8 Promyelocytic Leukemia (PML) Proteins from 5 different suppliers available. Additionally we are shipping PML Antibodies (121) and PML Kits (6) and many more products for this protein. A total of 144 PML products are currently listed.
1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, Trim19
list all proteins Gene Name GeneID UniProt
PML 5371 P29590
PML 18854 Q60953
Rat PML PML 315713  

Show all synonyms

PML Proteins (PML) by Origin

Select your origin of interest

More Proteins for PML Interaction Partners

Human Promyelocytic Leukemia (PML) interaction partners

  1. Suggest a novel role of PCGF2 (show PCGF2 Proteins) in arsenic trioxide-mediated degradation of PML-RARA (show RARA Proteins) that PCGF2 (show PCGF2 Proteins) might act as a negative regulator of UBE2I (show UBE2I Proteins) via direct interaction.

  2. Indicate the important role of PML/c-Myc (show MYC Proteins) axis in the maintenance of glioblastoma tumor stem cells. Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth.

  3. Our work provides a novel view of the physiologic function of PML, which participates in telomeres surveillance in normal cells. Our data further imply that a diminished PML function may contribute to cell senescence, genomic instability and tumorigenesis

  4. Authors demonstrate leukemogenicity of PAX5 (show PAX5 Proteins)-PML by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk (show BLNK Proteins)) is repressed by PAX5 (show PAX5 Proteins)-PML in leukemia cells; enforced expression of Blnk (show BLNK Proteins) increases survival despite introduction of PAX5 (show PAX5 Proteins)-PML.

  5. Mutations affect both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia.

  6. Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARalpha (show RARA Proteins) protein degradation in acute promyelocytic leukemia.

  7. Novel insight into the functional difference of acquired mutations of PML-RARA (show RARA Proteins) both in vitro and in the clinical setting.

  8. Authors performed mutational analysis to define a PML interaction motif within the E1B (show BCKDHB Proteins)-55K polypeptide. Results showed that E1B (show BCKDHB Proteins)-55K/PML binding is not required for p53 (show TP53 Proteins), Mre11 (show MRE11A Proteins) and Daxx (show DAXX Proteins) interaction.

  9. These data suggest that targeting PML by human herpesvirus 5 IE1 represents a strategy to antagonize both intrinsic and innate immune mechanisms.

  10. The results corroborated that PML-II plays a critical role in generating nuclear Lipid droplets in specific cell types.

Mouse (Murine) Promyelocytic Leukemia (PML) interaction partners

  1. both the PML-RARA (show RARA Proteins)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (APL (show FASL Proteins)) required DNMT3A (show DNMT3A Proteins)

  2. PML IV enhances global SUMO-1 (show SUMO1 Proteins) conjugation, particularly that of p53 (show TP53 Proteins), resulting in p53 (show TP53 Proteins) stabilization and activation.

  3. our findings challenge the predominant model in the field and we propose that PML/RARA (show RARA Proteins) initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.

  4. DNA-binding-defective PML/RARA (show RARA Proteins) mutants could not repress the transcription of retinoic acid regulated genes.

  5. A novel antioxidative mechanism by which PML regulates cellular oxidant homeostasis by controlling complex II integrity and Nrf2 (show NFE2L2 Proteins) activity and identified PML as an indispensable mediator of SFN (show SFN Proteins) activity.

  6. pRB (show PGR Proteins) can interact with PML specifically during senescence, suggesting that signaling events in senescence regulate assembly of PML and pRB (show PGR Proteins) to establish heterochromatin and create a permanent cell cycle arrest.

  7. Data suggest that acute promyelocytic leukemia (APL (show FASL Proteins)) differentiation is a default program triggered by clearance of promyelocytic leukemia-retinoic acid receptor alpha (show RARA Proteins) fusion oncoprotein PML/RARA (show RARA Proteins)-bound promoters.

  8. Our results add PML/TRIM19 to the growing list of TRIM (show TRAT1 Proteins) proteins implicated in both intrinsic and innate immunity.

  9. Oxidized PML spherical meshes recruit UBC9 (show UBE2I Proteins) and enhances PML sumoylation.

  10. ORF61 encoded the viral ribonucleotide reductase large subunit (show RRM1 Proteins) is a second PML-modifying protein.

PML Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PML

  • promyelocytic leukemia (PML)
  • promyelocytic leukemia (Pml)
  • 1200009E24Rik protein
  • AI661194 protein
  • MYL protein
  • PML protein
  • PP8675 protein
  • RGD1562602 protein
  • RNF71 protein
  • Trim19 protein

Protein level used designations for Promyelocytic Leukemia Proteins (PML)

promyelocytic leukemia , probable transcription factor PML , promyelocytic leukemia protein , protein PML , probable transcription factor PML-like , RING finger protein 71 , promyelocytic leukemia, inducer of , tripartite motif protein TRIM19 , tripartite motif-containing protein 19

415302 Gallus gallus
415304 Gallus gallus
453736 Pan troglodytes
700379 Macaca mulatta
100138545 Bos taurus
100388843 Callithrix jacchus
100607016 Nomascus leucogenys
5371 Homo sapiens
18854 Mus musculus
315713 Rattus norvegicus
Selected quality suppliers for PML Proteins (PML)
Did you look for something else?