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the data indicate that the WIP1 phosphatase functions to maintain insulin (show INS ELISA Kits) sensitivity and glucose homeostasis.
Study suggests a potential protective function of p53 (show TP53 ELISA Kits)-induced phosphatase 1 in mood stabilization.
loss of Wip1 phosphatase induces a p53 (show TP53 ELISA Kits)-dependent, but p21-independent, mechanism that impairs B-cell development by enhancing apoptosis in early B-cell precursors
our findings identify Wip1 as an intrinsic negative regulator of neutrophil inflammation in intestinal I/R injury process
the principal function of Wip1 in MSCs transformation is the maintenance of proliferative capacity; but knocking out Wip1 increases the migratory capacity of MSCs; this dual effect of Wip1 provides the potential for purposeful routing of MSCs
Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.
We identified Wip1 as a potentiator of prolactin (show PRL ELISA Kits) and HER2/neu (show ERBB2 ELISA Kits) signaling strictly in the molecular context of hormone-sensing cells.
Wip1 prevents the induction of cellular senescence at physiological oxygen levels by attenuating DDR (show DDR1 ELISA Kits) signaling in response to endogenous double-stranded breaks that form during DNA replication.
the absence of Wip1 blocked radiation-induced intestinal tumorigenesis irrespective of radiation quality.
augmenting WIP1 expression in aged animals markedly improved neuron formation and rescued a functional defect in fine odor discrimination in aged mice
squalene inhibits the ATM-dependent signaling pathway following DNA damage through intracellular induction of Wip1 expression.
Chemotherapy exposure and age influence the accumulation of PPM1D mutations in the peripheral blood mononuclear cells of ovarian cancer patients.
Knockdown of Wip1 enhances sensitivity to radiation in HeLa cells by inhibiting cell proliferation and inducing apoptosis through activation of p38 MAPK (show MAPK14 ELISA Kits).
Results showed evidence that Wip1 underwent Cdh1-dependent proteolysis during mitosis and sustained Wip1 activity during mitosis, resulting in mitotic delay at the metaphase to anaphase transition.
Study reveals a mechanism of stem cell aging, in which distinct effects of p53 and mTORC1 pathways on HSC aging are governed by Wip1.
WIP1 silencing reduced expression of MMP-9, VEGF-C, cyclin D1, and c-Myc, as well as migration and invasion of salivary adenoid cystic carcinoma cells. WIP1 expression was positively associated with ACC metastasis and prognosis.
Wip1 may be involved in the biological processes of nasopharyngeal cancer cell proliferation, apoptosis, and migration and invasion.
p21 (show CDKN1A ELISA Kits) might contribute to positive regulation of WIP1, resulting in dephosphorylation of the histone H2A variant gammaH2AX (show H2AFX ELISA Kits).
PPM1D plays an important role in promoting CDDP resistance.
data suggests that WIP1 inhibition represents a novel therapeutic approach to neuroblastoma (show ARHGEF16 ELISA Kits) that could be integrated with current chemotherapeutic approaches
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
, p53-induced protein phosphatase 1
, protein phosphatase 1D
, protein phosphatase 2C isoform delta
, protein phosphatase magnesium-dependent 1 delta
, protein phosphatase 1D magnesium-dependent, delta isoform
, protein phosphatase 2C delta isoform
, protein phosphatase Wip1
, wild-type p53-induced phosphatase 1