Browse our PPM1D Proteins (PPM1D)

Full name:
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D Proteins (PPM1D)
On are 5 Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) Proteins from 3 different suppliers available. Additionally we are shipping PPM1D Antibodies (75) and many more products for this protein. A total of 82 PPM1D products are currently listed.
AV338790, PP2C-DELTA, WIP1
list all proteins Gene Name GeneID UniProt
PPM1D 53892 Q9QZ67
PPM1D 8493 O15297
Rat PPM1D PPM1D 287585  

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PPM1D Proteins (PPM1D) by Origin

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More Proteins for PPM1D Interaction Partners

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) interaction partners

  1. WIP1 phosphatase plays a pro-adipogenic role by interacting directly with PPARgamma (show PPARG Proteins) and dephosphorylating p-PPARgamma (show PPARG Proteins) S112 in vitro and in vivo.

  2. this study shows that knock out of Wip1 in mouse aggravates colonic inflammation and increases neutrophils migration

  3. the data indicate that the WIP1 phosphatase functions to maintain insulin (show INS Proteins) sensitivity and glucose homeostasis.

  4. Study suggests a potential protective function of p53 (show TP53 Proteins)-induced phosphatase 1 in mood stabilization.

  5. loss of Wip1 phosphatase induces a p53 (show TP53 Proteins)-dependent, but p21-independent, mechanism that impairs B-cell development by enhancing apoptosis in early B-cell precursors

  6. our findings identify Wip1 as an intrinsic negative regulator of neutrophil inflammation in intestinal I/R injury process

  7. the principal function of Wip1 in MSCs transformation is the maintenance of proliferative capacity; but knocking out Wip1 increases the migratory capacity of MSCs; this dual effect of Wip1 provides the potential for purposeful routing of MSCs

  8. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.

  9. We identified Wip1 as a potentiator of prolactin (show PRL Proteins) and HER2/neu (show ERBB2 Proteins) signaling strictly in the molecular context of hormone-sensing cells.

  10. Wip1 prevents the induction of cellular senescence at physiological oxygen levels by attenuating DDR (show DDR1 Proteins) signaling in response to endogenous double-stranded breaks that form during DNA replication.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) interaction partners

  1. Wip1 activity and its relevance to cancer as an oncoprotein is reviewed

  2. The authors show that a global spread of ATM (show ATM Proteins) activity on chromatin and phosphorylation of ATM (show ATM Proteins) targets including KAP1 (show CDKN3 Proteins) control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM (show ATM Proteins) activity present at DNA lesions.

  3. Truncating and missense PPM1D mutations are associated with prostate cancer.

  4. this study shows that expression of Wip1 is decreased in patients with active inflammatory bowel disease

  5. Wip1 is frequently overexpressed in nonsmall cell lung cancer, which may serve an essential role in the p38MAPK/p53/p16 signaling pathway.

  6. Study identified 14 individuals with mild to severe Intellectual Disability (ID) and/or developmental delay and de novo truncating PPM1D mutations; all mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediated mRNA decay.

  7. PPM1D gene silencing combined with TMZ eradicates glioma cells through cell apoptosis and cell cycle arrest

  8. High PPM1D expression is associated with breast cancer.

  9. PPM1D in the chromosomal location 17q22-24 might be the most relevant candidate gene with respect to a potential functional implication in meningioma progression.

  10. PPM1D suppresses pancreatic cancer cell apoptosis via inhibition of the p38 MAPK (show MAPK14 Proteins)/p53 (show TP53 Proteins) pathway through both dephosphorylation of p38 MAPK (show MAPK14 Proteins) and downregulation of ASPP2 (show TP53BP2 Proteins).

PPM1D Protein Profile

Protein Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Alternative names and synonyms associated with PPM1D

  • protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d)
  • AV338790 protein
  • PP2C-DELTA protein
  • WIP1 protein

Protein level used designations for PPM1D

PP2C-delta , p53-induced protein phosphatase 1 , protein phosphatase 1D , protein phosphatase 2C isoform delta , protein phosphatase magnesium-dependent 1 delta , protein phosphatase 1D magnesium-dependent, delta isoform , protein phosphatase 2C delta isoform , protein phosphatase Wip1 , wild-type p53-induced phosphatase 1

53892 Mus musculus
8493 Homo sapiens
287585 Rattus norvegicus
417644 Gallus gallus
612934 Canis lupus familiaris
100525714 Sus scrofa
514005 Bos taurus
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