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the data indicate that the WIP1 phosphatase functions to maintain insulin (show INS Proteins) sensitivity and glucose homeostasis.
Study suggests a potential protective function of p53 (show TP53 Proteins)-induced phosphatase 1 in mood stabilization.
loss of Wip1 phosphatase induces a p53 (show TP53 Proteins)-dependent, but p21-independent, mechanism that impairs B-cell development by enhancing apoptosis in early B-cell precursors
our findings identify Wip1 as an intrinsic negative regulator of neutrophil inflammation in intestinal I/R injury process
the principal function of Wip1 in MSCs transformation is the maintenance of proliferative capacity; but knocking out Wip1 increases the migratory capacity of MSCs; this dual effect of Wip1 provides the potential for purposeful routing of MSCs
Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.
We identified Wip1 as a potentiator of prolactin (show PRL Proteins) and HER2/neu (show ERBB2 Proteins) signaling strictly in the molecular context of hormone-sensing cells.
Wip1 prevents the induction of cellular senescence at physiological oxygen levels by attenuating DDR (show DDR1 Proteins) signaling in response to endogenous double-stranded breaks that form during DNA replication.
the absence of Wip1 blocked radiation-induced intestinal tumorigenesis irrespective of radiation quality.
augmenting WIP1 expression in aged animals markedly improved neuron formation and rescued a functional defect in fine odor discrimination in aged mice
PPM1D gene silencing combined with TMZ eradicates glioma cells through cell apoptosis and cell cycle arrest
High PPM1D expression is associated with breast cancer.
PPM1D in the chromosomal location 17q22-24 might be the most relevant candidate gene with respect to a potential functional implication in meningioma progression.
PPM1D suppresses pancreatic cancer cell apoptosis via inhibition of the p38 MAPK (show MAPK14 Proteins)/p53 (show TP53 Proteins) pathway through both dephosphorylation of p38 MAPK (show MAPK14 Proteins) and downregulation of ASPP2 (show TP53BP2 Proteins).
squalene inhibits the ATM-dependent signaling pathway following DNA damage through intracellular induction of Wip1 expression.
Chemotherapy exposure and age influence the accumulation of PPM1D mutations in the peripheral blood mononuclear cells of ovarian cancer patients.
Knockdown of Wip1 enhances sensitivity to radiation in HeLa cells by inhibiting cell proliferation and inducing apoptosis through activation of p38 MAPK (show MAPK14 Proteins).
Results showed evidence that Wip1 underwent Cdh1-dependent proteolysis during mitosis and sustained Wip1 activity during mitosis, resulting in mitotic delay at the metaphase to anaphase transition.
Study reveals a mechanism of stem cell aging, in which distinct effects of p53 and mTORC1 pathways on HSC aging are governed by Wip1.
WIP1 silencing reduced expression of MMP-9, VEGF-C, cyclin D1, and c-Myc, as well as migration and invasion of salivary adenoid cystic carcinoma cells. WIP1 expression was positively associated with ACC metastasis and prognosis.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
, p53-induced protein phosphatase 1
, protein phosphatase 1D
, protein phosphatase 2C isoform delta
, protein phosphatase magnesium-dependent 1 delta
, protein phosphatase 1D magnesium-dependent, delta isoform
, protein phosphatase 2C delta isoform
, protein phosphatase Wip1
, wild-type p53-induced phosphatase 1