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Wip1 phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII (show CAMK2G Proteins).
Findings indicate that the PPM1D-Ulk1 (show ULK1 Proteins) axis plays a pivotal role in genotoxic stress-induced autophagy.
This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB.
WIP1 phosphatase plays a pro-adipogenic role by interacting directly with PPARgamma (show PPARG Proteins) and dephosphorylating p-PPARgamma (show PPARG Proteins) S112 in vitro and in vivo.
this study shows that knock out of Wip1 in mouse aggravates colonic inflammation and increases neutrophils migration
the data indicate that the WIP1 phosphatase functions to maintain insulin (show INS Proteins) sensitivity and glucose homeostasis.
Study suggests a potential protective function of p53 (show TP53 Proteins)-induced phosphatase 1 in mood stabilization.
loss of Wip1 phosphatase induces a p53 (show TP53 Proteins)-dependent, but p21-independent, mechanism that impairs B-cell development by enhancing apoptosis in early B-cell precursors
our findings identify Wip1 as an intrinsic negative regulator of neutrophil inflammation in intestinal I/R injury process
the principal function of Wip1 in MSCs transformation is the maintenance of proliferative capacity; but knocking out Wip1 increases the migratory capacity of MSCs; this dual effect of Wip1 provides the potential for purposeful routing of MSCs
Wip1 suppressed ovarian cancer cell invasion, migration, epithelial to mesenchymal transition (EMT (show ITK Proteins)), and ovarian cancer metastasis in xenograft animal models.
model reproduces the observed cellular phenotypes in experiments: oscillatory (for low DNA damage) regulated by negative feedback loops involving mainly p53 (show TP53 Proteins) and Mdm2 (show MDM2 Proteins) and apoptotic or senescent (for high DNA damage) regulated by the positive p53 (show TP53 Proteins)/Wip1/miR-16 (show GDE1 Proteins) feedback loop
Wip1 activity and its relevance to cancer as an oncoprotein is reviewed
The authors show that a global spread of ATM (show ATM Proteins) activity on chromatin and phosphorylation of ATM (show ATM Proteins) targets including KAP1 (show CDKN3 Proteins) control Plk1 re-activation. These phosphorylations are rapidly counteracted by the chromatin-bound phosphatase Wip1, allowing cell cycle restart despite persistent ATM (show ATM Proteins) activity present at DNA lesions.
Truncating and missense PPM1D mutations are associated with prostate cancer.
this study shows that expression of Wip1 is decreased in patients with active inflammatory bowel disease
Wip1 is frequently overexpressed in nonsmall cell lung cancer, which may serve an essential role in the p38MAPK/p53/p16 signaling pathway.
Study identified 14 individuals with mild to severe Intellectual Disability (ID) and/or developmental delay and de novo truncating PPM1D mutations; all mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediated mRNA decay.
PPM1D gene silencing combined with TMZ eradicates glioma cells through cell apoptosis and cell cycle arrest
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
, p53-induced protein phosphatase 1
, protein phosphatase 1D
, protein phosphatase 2C isoform delta
, protein phosphatase magnesium-dependent 1 delta
, protein phosphatase 1D magnesium-dependent, delta isoform
, protein phosphatase 2C delta isoform
, protein phosphatase Wip1
, wild-type p53-induced phosphatase 1