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After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) cycling and induces p53 (show TP53 Proteins)-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC (show FUT1 Proteins) self-renewal and accumulation of DNA damage in p53 (show TP53 Proteins) null HSCs.
Our study demonstrates a novel role for ASPP1 and ASPP2 (show TP53BP2 Proteins) in the death of retinal ganglion cells.
Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53 (show TP53 Proteins)-independent manner.
Results showed that the protein expression levels of ASPP1 in esophageal squamous cell carcinoma (ESCC) tissues and in paired noncancerous tissues were similar but was significantly associated with histological differentiation and invasive depth which suggest that it might be involved in the progression of ESCC.
Increased expression of p53 (show TP53 Proteins) and ASPP1 and downregulation of iASPP (show PPP1R13L Proteins).
ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.
ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis.
ASPP1 and ASPP2 (show TP53BP2 Proteins) cooperate with oncogenic RAS to enhance the transcription and apoptotic function of p53 (show TP53 Proteins).
When the Px(T)PxR (show NR1I2 Proteins) motif is deleted or mutated via insertion of a phosphorylation site mimic (T311D), PP-1c fails to bind to all three ASPP proteins, ASPP1, ASPP2 (show TP53BP2 Proteins) and iASPP (show PPP1R13L Proteins).
the mRNA expression of ASPP1 and ASPP2 (show TP53BP2 Proteins) was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53 (show TP53 Proteins)
ASPP1 promoter methylation may be associated with the malignant progression of non-small cell lung cancer, and ASPP1 expression promotes cellular apoptosis.
The ability of ASPP1 to activate YAP (show YAP1 Proteins) results in the decreased expression of LATS2, which lowers the ability of p53 (show TP53 Proteins) to induce p21 (show CDKN1A Proteins), cell-cycle arrest and senescence.
overexpression of ASPP1 rendered MCF-7 and MDA-MB231 breast cancer cells more sensitive to resveratrol-mediated apoptosis via the E2F (show E2F1 Proteins) pathway
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
protein phosphatase type 2C alpha 1
, protein phosphatase 1, regulatory (inhibitor) subunit 13B
, apoptosis-stimulating protein of p53, 1
, apoptosis-stimulating of p53 protein 1-like
, apoptosis-stimulating of p53 protein 1
, protein phosphatase 1 regulatory subunit 13B
, transformation related protein 53 binding protein 2
, tumor protein p53 binding protein, 2
, tumor protein p53-binding protein, 2
, apoptosis-stimulating protein of p53