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Human SERPINB5 ELISA Kit for Sandwich ELISA - ABIN419075
Baek, Yeo, Chang, Kim, Kim, Park, Park, Choi, Kim, Oh: Serpin B5 is a CEA-interacting biomarker for colorectal cancer. in International journal of cancer. Journal international du cancer 2014
maspin is a powerful context-dependent tumor suppressor.
these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR (show EGFR ELISA Kits) ligands, but EGF (show EGF ELISA Kits) appears to be the only able to induce SerpinB5 nuclear localization.
perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression
evidence demonstrates that D(346) is a critical cis (show CISH ELISA Kits)-element in maspin sequence that determines the molecular context and subcellular localization of maspin.
a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth.
results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation
The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo.
SERPINB5 and AKAP12 (show AKAP12 ELISA Kits) may have a role in increased metastasis in pancreatic ductal adenocarcinoma
PAR-1 (show MARK2 ELISA Kits) negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype
Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway.
Mechanistic investigations found that quercetin suppressed Snail (show SNAI1 ELISA Kits)-dependent Akt (show AKT1 ELISA Kits) activation by upregulating maspin and Snail (show SNAI1 ELISA Kits)-independent a disintegrin and metalloproteinase (ADAM) 9 (show ADAM9 ELISA Kits) expression pathways to modulate the invasive ability of NSCLC cells.
High HDAC1 (show HDAC1 ELISA Kits) expression may contribute to the aggressiveness of human breast cancer with cytoplasmic-only expression of maspin
These results reveal a novel biological function of Maspin in modulating macrophage activity
Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer.
Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence
Cytoplasmic expression of maspin could be an independent unfavourable prognostic indicator in patients with lung squamous cell carcinoma (SCC (show CYP11A1 ELISA Kits)).
Results demonstrated that Maspin suppressed growth, proliferation and invasion by delaying cell cycle transition and promoting apoptosis in cutaneous squamous cell carcinoma cells.
This is the first time that these parts of maspin have been highlighted as having key roles affecting cell function
In GC with associated metaplasia, cytoplasmic maspin is predominant; the nuclear shift induces local aggressiveness and risk of node metastases, whereas total loss can indicate a risk of distant metastases
maspin mRNA is significantly up-regulated in tissues of pulmonary adenocarcinoma patients
may act as a tumor suppressor
peptidase inhibitor 5
, protease inhibitor 5
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
, serine (or cysteine) proteinase inhibitor, clade B, member 5
, serine protease inhibitor 7
, serpin B5
, protease inhibitor 5 (maspin)
, serine (or cysteine) peptidase inhibitor, clade B, member 5