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This data indicates that 14-3-3sigma contributes to P-gp (show ABCB4 Proteins) overexpression through interaction with PXR (show NR1I2 Proteins) with rifampin and paclitaxel treatment.
The impact of AKT1 (show AKT1 Proteins) on glucocorticoid receptor (GR (show NR3C1 Proteins))-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (show YWHAQ Proteins), was examined.
Data showed that 14-3-3s contributed to ionizing radiation (IR) resistance possibly by regulating cell cycle progression and non-homologous end joining repair of IR-induced DNA double strand breaks via regulating the expression of Chk2 (show CHEK2 Proteins) and PARP1 (show PARP1 Proteins). These findings suggest that 14-3-3s may be an upstream master regulator in chemo and radiation resistance and cancer cell survival.
Structural basis for the interaction of a human HSPB6 (show HSPB6 Proteins) protein with the 14-3-3 (show YWHAQ Proteins) universal signaling regulator has been reported.
Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 (show YWHAQ Proteins) binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 (show YWHAQ Proteins) isoforms of a different type.
Data suggest that 14-3-3 sigma protein exhibits two individual secondary binding sites for peptide fragments of TAZ (show TAZ Proteins) protein; these two pockets appear to be part of at least three physiologically relevant and structurally characterized 14-3-3 protein (show YWHAE Proteins)-protein interaction interfaces.
These results suggest that SFN facilitates lung tumor development and progression. SFN appears to be a novel oncogene (show RAB1A Proteins) with potential as a therapeutic target
SFN regulates cancer metabolic reprogramming. It opposes tumor-promoting metabolic programs by enhancing c-Myc (show MYC Proteins) poly-ubiquitination and degradation. SFN suppresses cancer glycolysis, glutaminolysis, and mitochondrial biogenesis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (show TUBB Proteins) cytoskeleton mediated by binding Tau protein.
K17 (show KRT17 Proteins) expression is accompanied by cytoplasmic expression of 14-3-3 sigma, indicative of their functional relationship in oral squamous cell carcinoma
14-3-3sigma stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion.
these data provides the first evidence that 14-3-3 sigma is a Smad3 (show SMAD3 Proteins)-dependent target gene of TGF-beta1 (show TGFB1 Proteins).
14-3-3sigma plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3beta and enhancing Wnt-signaled GSK-3beta inactivation.
study shows that p63 and 14-3-3sigma play opposing roles in the development of skin tumors and that the accumulation of p63 is essential for Ras/14-3-3sigma mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
Data show that endogenous 14-3-3sigma protein formed a complex with FOXO1 (show FOXO1 Proteins) protein.
14-3-3 sigma is required for TGF-beta1 (show TGFB1 Proteins)-mediated growth inhibition in mouse mammary epithelial cells.
14-3-3 sigma is needed for normal hair growth
14-3-3sigma is critical for regulating corneal epithelial proliferation and differentiation by regulating Notch (show NOTCH1 Proteins) signaling activity.
14-3-3 (show YWHAQ Proteins) can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 (show YWHAQ Proteins) complex in the cytoplasm.
Efp (show TRIM25 Proteins) targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
, 14-3-3 protein sigma
, epithelial cell marker protein 1
, 14-3-3 sigma protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide