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Human Stratifin Protein expressed in Escherichia coli (E. coli) - ABIN2003467
Leffers, Madsen, Rasmussen, Honoré, Andersen, Walbum, Vandekerckhove, Celis: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. in Journal of molecular biology 1993
Show all 3 references for ABIN2003467
Mouse (Murine) Stratifin Protein expressed in Escherichia coli (E. coli) - ABIN2007990
Wilker, Grant, Artim, Yaffe: A structural basis for 14-3-3sigma functional specificity. in The Journal of biological chemistry 2005
Show all 3 references for ABIN2007990
Human Stratifin Protein expressed in Escherichia coli (E. coli) - ABIN666918
Benzinger, Muster, Koch, Yates, Hermeking: Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. in Molecular & cellular proteomics : MCP 2005
Show all 2 references for ABIN666918
These results suggest that SFN facilitates lung tumor development and progression. SFN appears to be a novel oncogene (show RAB1A Proteins) with potential as a therapeutic target
SFN regulates cancer metabolic reprogramming. It opposes tumor-promoting metabolic programs by enhancing c-Myc (show MYC Proteins) poly-ubiquitination and degradation. SFN suppresses cancer glycolysis, glutaminolysis, and mitochondrial biogenesis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (show TUBB Proteins) cytoskeleton mediated by binding Tau protein.
K17 (show KRT17 Proteins) expression is accompanied by cytoplasmic expression of 14-3-3 sigma, indicative of their functional relationship in oral squamous cell carcinoma
SFN affects the water-holding capacity, barrier function and dermal matrix components in photoaging skin. An increase of SFN triggered by UVB irradiation may be one of the causes of alterations observed in photoaging skin.
Results suggest a role of Wig-1 (show ZMAT3 Proteins) as a survival factor that directs the p53 (show TP53 Proteins) stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS (show FAS Proteins) and 14-3-3sigma mRNA levels.
14-3-3sigma alone or combined with HSP70 (show HSP70 Proteins) are potential prognostic biomarkers for HCC (show FAM126A Proteins)
Cdc25B (show CDC25B Proteins) upregulation and 14-3-3sigma downregulation might promote development of bladder cancer and suggested a poor prognosis.
Studied differential protein expression of an anoikis-resistant CCA (show FBN2 Proteins) cell line culture, under attachment and nonattachment conditions. Data reveal 14-3-3sigma protein was intensely upregulated in detached CCA (show FBN2 Proteins) cells.
stratifin plays a role in regulating plakophilin-3 (show PKP3 Proteins) incorporation into the desmosomal plaque by forming a plakophilin-3 (show PKP3 Proteins) stratifin complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.
14-3-3sigma stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion.
these data provides the first evidence that 14-3-3 sigma is a Smad3 (show SMAD3 Proteins)-dependent target gene of TGF-beta1 (show TGFB1 Proteins).
14-3-3sigma plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3beta and enhancing Wnt-signaled GSK-3beta inactivation.
study shows that p63 and 14-3-3sigma play opposing roles in the development of skin tumors and that the accumulation of p63 is essential for Ras/14-3-3sigma mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
Data show that endogenous 14-3-3sigma protein formed a complex with FOXO1 (show FOXO1 Proteins) protein.
14-3-3 sigma is required for TGF-beta1 (show TGFB1 Proteins)-mediated growth inhibition in mouse mammary epithelial cells.
14-3-3 sigma is needed for normal hair growth
14-3-3sigma is critical for regulating corneal epithelial proliferation and differentiation by regulating Notch (show NOTCH1 Proteins) signaling activity.
14-3-3 (show YWHAQ Proteins) can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 (show YWHAQ Proteins) complex in the cytoplasm.
Efp (show TRIM25 Proteins) targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
, 14-3-3 protein sigma
, epithelial cell marker protein 1
, 14-3-3 sigma protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide