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Browse our Cathepsin D Proteins (CTSD)

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Cathepsin D Proteins (CTSD)
On are 67 Cathepsin D (CTSD) Proteins from 18 different suppliers available. Additionally we are shipping Cathepsin D Antibodies (320) and Cathepsin D Kits (79) and many more products for this protein. A total of 483 Cathepsin D products are currently listed.
CatD, Cathd, CD, CLN10, CPSD, CTSD, DDBDRAFT_0205785, DDBDRAFT_0215012, DDB_0205785, DDB_0215012, DKFZp469J0315, fb93e11, fj17b09, LOC398557, LOC100136761, wu:fb93e11, wu:fj17b09
list all proteins Gene Name GeneID UniProt
CTSD 1509 P07339
CTSD 13033 P18242
CTSD 171293  

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Cathepsin D Proteins (CTSD) by Origin

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Top referenced Cathepsin D Proteins

  1. Human Cathepsin D Protein expressed in HEK-293 - ABIN2666497 : Bidère, Lorenzo, Carmona, Laforge, Harper, Dumont, Senik: Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. in The Journal of biological chemistry 2003 (PubMed)
    Show all 8 references for ABIN2666497

  2. Human Cathepsin D Protein expressed in HEK-293 Cells - ABIN2180944 : Zhang, Li, Martin, Aebersold: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. in Nature biotechnology 2003 (PubMed)
    Show all 3 references for ABIN2180944

  3. Human Cathepsin D Protein expressed in Escherichia coli (E. coli) - ABIN1046778 : Faust, Kornfeld, Chirgwin: Cloning and sequence analysis of cDNA for human cathepsin D. in Proceedings of the National Academy of Sciences of the United States of America 1985 (PubMed)
    Show all 3 references for ABIN1046778

More Proteins for Cathepsin D Interaction Partners

Zebrafish Cathepsin D (CTSD) interaction partners

Silk Worm Cathepsin D (CTSD) interaction partners

  1. These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.

Human Cathepsin D (CTSD) interaction partners

  1. Secreted PGRN (show GRN Proteins) is incorporated into cells via sortilin (show SORT1 Proteins) or cation-independent mannose 6-phosphate receptor (show IGF2R Proteins), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (show GRN Proteins) levels led to a cell-type-specific increase of insoluble TDP-43 (show TARDBP Proteins). In the brain tissue of FTLD-TDP patients with PGRN (show GRN Proteins) deficiency, CTSD and phosphorylated TDP-43 (show TARDBP Proteins) accumulated in neurons

  2. CTSD, in need of its catalytic activity, may promote proliferation in advanced glycation end products-treated human umbilical vein endothelial cells independent of the autophagy-lysosome pathway.

  3. Cathepsin D facilitates the TRAIL-induced apoptosis of MDA-MB-231 breast cancer cells in enzymatic activity-dependent manner. Caspase-8 (show CASP8 Proteins) and Bid (show BID Proteins) proteins are the CD targets. The modulatory role of CD in cell response to TRAIL was also confirmed in another breast cancer cell line SKBR3.

  4. Gene expression level of CTSD is significantly higher in AD patients when compared to normal controls.

  5. There was a significant difference between groups with and without endothelial dysfunction in terms of cathepsin D levels, and negative and significant correlations were found between brachial artery FMD (show FLNA Proteins)% and cathepsin D levels. Cathepsin D, which is known to be associated with atherosclerosis, may play a role in the proce

  6. Serum CTSB (show CTSB Proteins) and CTSD concentrations were found to have a diagnostic value in NPC (show NPC1 Proteins). However, the CTSB (show CTSB Proteins) and CTSD serum levels had no prognostic role for the outcome in nasopharyngeal carcinoma patients.

  7. Fibroblasts from Niemann-Pick type C (NPC (show NPC1 Proteins)) disease patients with low levels of NPC1 (show NPC1 Proteins) protein have high amounts of procathepsin D but reduced quantities of the mature protein, thus showing a diminished cathepsin D activity.

  8. Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).

  9. Data show that co-silencing of tricho-rhino (show RHNO1 Proteins)-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation.

  10. Transcellular transmission of alpha-synuclein aggregates is increased in CTSD mutated cells.

Mouse (Murine) Cathepsin D (CTSD) interaction partners

  1. Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (show DNAJC5 Proteins)-dependent cathepsins B and L, but not the Asp (show C3 Proteins)-dependent cathepsin D.

  2. these results suggest that inhibition of lysosomal proteases, such as CtsD, could be a new therapeutic approach to reduce renal fibrosis and slow progression of chronic kidney disease.

  3. The neuroectoderm specific cathepsin D (Ctsd) knock-out mice survived about 5.5 days longer.

  4. Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).

  5. This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.

  6. Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.

  7. Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB.

  8. Mouse prolactin (show PRL Proteins) was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin (show PRL Proteins) fragment and Cath D expression increased during mammary gland involution.

  9. Cathepsin D was not inherent to sperm themselves, but rather of epididymal origin and was presumably transported to the sperm surface via epididymosomes.

  10. TGase 2 (show TGM2 Proteins) may regulate the balance between cell survival and cell death through the modulation of CTSD levels.

Cow (Bovine) Cathepsin D (CTSD) interaction partners

  1. Association of polymorphisms in calpain 1 (show CAPN1 Proteins), (mu/I) large subunit, calpastatin (show CAST Proteins), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.

  2. findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease

Pig (Porcine) Cathepsin D (CTSD) interaction partners

Rabbit Cathepsin D (CTSD) interaction partners

  1. The effect of heavy metal cations on the activity of cathepsin D, was studied.

Cathepsin D (CTSD) Protein Profile

Protein Summary

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Alternative names and synonyms associated with Cathepsin D (CTSD)

  • cathepsin D (ctsd)
  • cathepsin D (LOC398557)
  • cathepsin D (Cathd)
  • cathepsin d (AaeL_AAEL006169)
  • cathepsin D (LOC100136761)
  • cathepsin D (CTSD)
  • cathepsin D (ctsD)
  • cathepsin D (catd)
  • cathepsin D (Ctsd)
  • cathepsin D (LOC100101595)
  • CatD protein
  • Cathd protein
  • CD protein
  • CLN10 protein
  • CPSD protein
  • CTSD protein
  • DDBDRAFT_0205785 protein
  • DDBDRAFT_0215012 protein
  • DDB_0205785 protein
  • DDB_0215012 protein
  • DKFZp469J0315 protein
  • fb93e11 protein
  • fj17b09 protein
  • LOC398557 protein
  • LOC100136761 protein
  • wu:fb93e11 protein
  • wu:fj17b09 protein

Protein level used designations for Cathepsin D Proteins (CTSD)

etID16901.18 , cathepsin D , aspartic protease , cathepsin d , preprocathepsin D , ceroid-lipofuscinosis, neuronal 10 , lysosomal aspartyl peptidase , lysosomal aspartyl protease , cathepsin D (lysosomal aspartyl peptidase) , cathepsin D (lysosomal aspartyl protease) , prepro-cathepsin D, prepro-CD

65225 Danio rerio
398557 Xenopus laevis
443721 Xenopus laevis
692768 Bombyx mori
5567565 Aedes aegypti
100136761 Oncorhynchus mykiss
100137367 Papio anubis
100168373 Acyrthosiphon pisum
100172401 Pongo abelii
8622052 Dictyostelium discoideum AX4
100528208 Ictalurus punctatus
1509 Homo sapiens
101094625 Felis catus
13033 Mus musculus
171293 Rattus norvegicus
282883 Bos taurus
483662 Canis lupus familiaris
494568 Sus scrofa
100101595 Oryctolagus cuniculus
100735735 Cavia porcellus
396090 Gallus gallus
443060 Ovis aries
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