Browse our DPP4 Proteins (DPP4)

Full name:
Dipeptidyl-Peptidase 4 Proteins (DPP4)
On are 52 Dipeptidyl-Peptidase 4 (DPP4) Proteins from 15 different suppliers available. Additionally we are shipping DPP4 Antibodies (626) and DPP4 Kits (82) and many more products for this protein. A total of 779 DPP4 products are currently listed.
ADABP, ADCP2, Cd26, Dpp-4, DPP4, DPPIV, FAPA, im:7145318, MGC81966, MOP9.8, MOP9_8, si:ch73-2d23.3, THAM, TP103, zgc:152900
list all proteins Gene Name GeneID UniProt
DPP4 1803 P27487
DPP4 13482 P28843
DPP4 25253 P14740

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DPP4 Proteins (DPP4) by Origin

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Top referenced DPP4 Proteins

  1. Cynomolgus DPP4 Protein expressed in Human Cells - ABIN2009956 : Morimoto, Lord, Zhang, Duke-Cohan, Letvin, Schlossman: Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 5 references for 2009956

  2. Human DPP4 Protein expressed in Human Cells - ABIN2003230 : Hinke, Pospisilik, Demuth, Mannhart, Kühn-Wache, Hoffmann, Nishimura, Pederson, McIntosh: Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs. in The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for 2003230

  3. Cynomolgus DPP4 Protein expressed in Human Cells - ABIN2009954 : Reinhold, Kähne, Steinbrecher, Wrenger, Neubert, Ansorge, Brocke: The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. in Biological chemistry 2002 (PubMed)
    Show all 5 references for 2009954

  4. Human DPP4 Protein expressed in HEK-293 Cells - ABIN2180984 : Endo, Harigae, Nagai, Fujie, Meguro, Watanabe, Furuyama, Kameoka, Okuda, Hayashi: Two chronic myelogenous leukaemia cell lines which represent different stages of erythroid differentiation. in British journal of haematology 1994 (PubMed)
    Show all 5 references for 2180984

  5. Mouse (Murine) DPP4 Protein expressed in Human Cells - ABIN2008231 : Steinbrecher, Reinhold, Quigley, Gado, Tresser, Izikson, Born, Faust, Neubert, Martin, Ansorge, Brocke: Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
    Show all 5 references for 2008231

  6. Human DPP4 Protein expressed in Human Cells - ABIN2003228 : Pro, Dang: CD26/dipeptidyl peptidase IV and its role in cancer. in Histology and histopathology 2004 (PubMed)
    Show all 4 references for 2003228

  7. Human DPP4 Protein expressed in Hi-5 - ABIN666712 : Barnett: DPP-4 inhibitors and their potential role in the management of type 2 diabetes. in International journal of clinical practice 2006 (PubMed)
    Show all 2 references for 666712

More Proteins for DPP4 Interaction Partners

Human Dipeptidyl-Peptidase 4 (DPP4) interaction partners

  1. Suggest DPP-4 inhibition has a neutral effect on cardiovascular risk in type 2 diabetics without a history of heart failure or renal insufficiency.

  2. To clarify whether DPP4 alters its general or partial structure according to the inhibitor used and whether DPP4 has a common rule for inhibitor binding, this study comprehensively analyzed X-ray cocrystal structures of DPP-4 and its inhibitor. All the main and side chains in the inhibitor binding area were minimally altered, except for a few side chains, despite binding to inhibitors of various shapes.

  3. DPP-4-dependent insulin like growth factor-1 (show IGF1 Proteins) inhibition in valvular interstitial cells contributes to aortic calcification.

  4. Fibroblast activation protein (P=.00117) was stronger than grade and stage in predicting clinical aggressiveness in clear cell renal cell carcinoma (show MOK Proteins).

  5. Data suggest that, in obesity, serum levels of active GLP1 (show GCG Proteins) are down-regulated and serum levels of soluble DPP4 are up-regulated; DPP4 levels correlate negatively with active GLP-1 (show GCG Proteins) levels but are positively associated with insulin (show INS Proteins) resistance; thus, DPP4 may be biomarker for insulin (show INS Proteins) resistance. This study was conducted in Malaysia. (GLP1 (show GCG Proteins) = glucagon-like peptide 1 (show GCG Proteins); DPP4 = dipeptidyl peptidase 4)

  6. YS110 is a humanised IgG1 monoclonal antibody with high affinity to the CD26 antigen. YS110 demonstrated preclinical anti-tumour effects without significant side effects

  7. Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides

  8. like AprA, DPPIV is a chemorepellent for, and inhibits the proliferation of, D. discoideum cells, and that AprA binds some DPPIV binding partners such as fibronectin (show FN1 Proteins).

  9. CD26 expression should be incorporated in B-CLL patients risk assessment along with well known prognostic factors, since it seems to have a relationship with the tumor mass and influences TTT.

  10. expression of FAP in primary tumors and in their metastases was associated both with synchronous metastases and also with metastases to the lymph nodes

Cow (Bovine) Dipeptidyl-Peptidase 4 (DPP4) interaction partners

  1. Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV).

  2. Data demonstrate that dipeptidyl peptidase II (show DPP7 Proteins) can form a complex with adenosine deaminase (show ADA Proteins), but with one order of magnitude higher dissociation constant than that of DPPIV.

Pig (Porcine) Dipeptidyl-Peptidase 4 (DPP4) interaction partners

  1. This study shows that porcine DPP-IV is generally inhibited with greater potency by protein-derived peptides than is the human enzyme

  2. DPP-IV from porcine kidney cortex was characterized.

  3. Neutral endopeptidase 24.11 (show MME Proteins) and DPP-IV is superior to DPP-IV inhibition alone in preserving intact GLP-1 (show GCG Proteins), which implies possibility that the combination has therapeutic potential.

  4. Results describe the distribution of dipeptidyl peptidase IV-like activity enzymes in porcine tissue sections by RT-PCR.

Mouse (Murine) Dipeptidyl-Peptidase 4 (DPP4) interaction partners

  1. these findings identify distinct roles for DPP4 in the endothelial cell versus the bone marrow compartment for selective incretin degradation and DPP4 inhibition-mediated glucoregulation.

  2. The trimeric form receptor-binding domain of MERS-CoV spike protein bound strongly to the receptor of MERS-CoV, dipeptidyl peptidase 4 (DPP4), and elicited robust RBD (show CACNA1D Proteins)-specific neutralizing antibodies in mice.

  3. the data show that glucose-induced expression of Dpp4 in the liver is facilitated by demethylation of the Dpp4 gene early in life. This might contribute to early deteriorations in hepatic function, which in turn result in metabolic disease such as hepatosteatosis later in life.

  4. study reveals a cross talk between ATR signaling and DPP4 activation in the regulation of megalin (show LRP2 Proteins) and underscores the significance of targeting DPP4 in the prevention of obesity related kidney injury progression.

  5. Data (including data from studies in knockout mice) suggest that Cd26 (dipeptidyl peptidase IV) plays role in development and progression vs. resolution of ulcerative colitis; Cd26 deficiency in knockout mice is associated with heightened response to DSS (show PMP22 Proteins) (dextran sulfate sodium) in inducing colitis and is accompanied by increased expression of NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit and distinct changes in leukocyte trafficking/infiltra...

  6. DPP4 posttranslational modification of selected chemokines by truncation modifies their functional activities.

  7. DPP (show DSPP Proteins)-4I, MK0626, but not native incretins has protective effects against AAA (show AAAS Proteins) in Ang II (show AGT Proteins)-infused Apoe (show APOE Proteins)/ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall

  8. Plasminogen (show PLG Proteins) may regulate DPP-4 activity and glucose metabolism.

  9. DPP-4 inhibition may have direct protective effects on the post-myocardial infarction heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1a/CXCR4 (show CXCR4 Proteins)-mediated STAT3 (show STAT3 Proteins) signaling pathway.

  10. Data suggest that pharmacological stimulation of serotonin 5Ht1b (show HTR1B Proteins) receptor enhances up-regulation of plasma Glp1 (glucagon-like peptide 1 (show GCG Proteins)) induced by Dpp4 (dipeptidylpeptidase 4) inhibition independently of feeding and also improves glucose tolerance.

DPP4 Protein Profile

Protein Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

Alternative names and synonyms associated with DPP4

  • dipeptidyl-peptidase 9 (dpp9)
  • dipeptidyl-peptidase 4 (dpp4)
  • dipeptidyl-peptidase 4 (DPP4)
  • prolyl oligopeptidase family protein (AT5G24260)
  • dipeptidylpeptidase 4 (Dpp4)
  • fibroblast activation protein, alpha (FAP)
  • ADABP protein
  • ADCP2 protein
  • Cd26 protein
  • Dpp-4 protein
  • DPP4 protein
  • DPPIV protein
  • FAPA protein
  • im:7145318 protein
  • MGC81966 protein
  • MOP9.8 protein
  • MOP9_8 protein
  • si:ch73-2d23.3 protein
  • THAM protein
  • TP103 protein
  • zgc:152900 protein

Protein level used designations for Dipeptidyl-Peptidase 4 Proteins (DPP4)

dipeptidyl peptidase 9 , dipeptidyl-peptidase 4 , dipeptidyl-peptidase IV , dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) , dipeptidylpeptidase IV , dipeptidyl peptidase 4 , ADCP-2 , DPP IV , T-cell activation antigen CD26 , adenosine deaminase complexing protein 2 , dipeptidyl peptidase IV , dipeptidylpeptidase 4 , dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) , ACT3 , ADCP-I , WC10 , activation molecule 3 , adenosine deaminase complexing protein , dipeptidyl-peptidase iv , thymocyte-activating molecule , GP110 glycoprotein , bile canaliculus domain-specific membrane glycoprotein , 170 kDa melanoma membrane-bound gelatinase , integral membrane serine protease , seprase

768170 Danio rerio
397888 Xenopus laevis
459689 Pan troglodytes
478767 Canis lupus familiaris
654491 Macaca mulatta
832493 Arabidopsis thaliana
8955655 Sphingobium japonicum UT26S
100022348 Monodelphis domestica
100170324 Ovis aries
100173322 Pongo abelii
100605220 Nomascus leucogenys
1803 Homo sapiens
281122 Bos taurus
397492 Sus scrofa
493787 Felis catus
100301982 Danio rerio
13482 Mus musculus
25253 Rattus norvegicus
2191 Homo sapiens
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