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Fos and phosphorylation of extracellular signal-regulated kinases (ERK (show EPHB2 ELISA Kits)) were used to look for evidence that interneurons expressing GRP (show UCMA ELISA Kits) were activated following intradermal injection of chloroquine.
GRP (show UCMA ELISA Kits) is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway
BNP-NPRA (show NPR1 ELISA Kits) signaling is involved in both itch and pain and does not function upstream of the GRP (show UCMA ELISA Kits)-GRPR (show GRPR ELISA Kits) dedicated neuronal pathway.
The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons.
nonamidated peptides derived from the C terminus of pro-GRP (show UCMA ELISA Kits) are expressed in significant quantities in colorectal cancer cell lines
GRP (show UCMA ELISA Kits) delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN (show SRI ELISA Kits) cells
The GRP (show UCMA ELISA Kits) receptor system does not mediate kappa opioid receptor (show OPRK1 ELISA Kits) antagonist (GNTI (show MGAT1 ELISA Kits))-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor (show OPRK1 ELISA Kits) agonist nalfurafine.
These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR (show GRPR ELISA Kits)-expressing cells.
A general possible effect of GRP (show UCMA ELISA Kits) on cortical inhibitory transmission, was shown.
GRP/GRP (show UCMA ELISA Kits)-R (show GRPR ELISA Kits) play a transient and non-critical role in intestinal development
Serum Pro-GRP (show LSM4 ELISA Kits) was promising biomarker for SCLC diagnosis.
CEA (show CEACAM5 ELISA Kits), NSE (show ENO2 ELISA Kits), CA125 (show MUC16 ELISA Kits) and pro-GRP (show LSM4 ELISA Kits) could serve as biomarkers for SCLC, and CEA (show CEACAM5 ELISA Kits) and CYFRA21-1 could serve as biomarkers for NSCLC. Pro-GRP (show LSM4 ELISA Kits), CA125 (show MUC16 ELISA Kits) and CEA (show CEACAM5 ELISA Kits) were related to the clinical stages of lung cancer
Data show that serum neuron-specific enolase (show ENO2 ELISA Kits), cytokeratin 19 (show KRT19 ELISA Kits) fragment 21-1, pro-gastrin-releasing peptide, squamous cell carcinoma antigen, tissue inhibitor of metalloproteinase-1, and human epididymis protein 4 are not associated with brain metastases.
No association of 16 GRP (show LSM4 ELISA Kits) and 7 GRPR (show GRPR ELISA Kits) variants were found with agoraphobia with/without panic disorder.
the role of autophagy in the degradation of gastrin-releasing peptide and subsequent inhibition of angiogenesis
The Gastrin-releasing peptide(GRP)triggers the growth of HepG2 cells through blocking the ER stress-mediated pathway.
GRP (show LSM4 ELISA Kits) silencing decreases anchorage-independent growth, inhibits cell migration and neuroblastoma (show ARHGEF16 ELISA Kits) cell-mediated angiogenesis.
GRP (show LSM4 ELISA Kits)-expressing C and A delta fibers that coexpress SP or CGRP (show S100A12 ELISA Kits) makes these neurons pruriceptors.
The levels of GRP (show LSM4 ELISA Kits) were upregulated in cells treated with HGF (show HGF ELISA Kits) in a dose-dependent manner. HGF (show HGF ELISA Kits)-induced expression of Ets-1 (show ETS1 ELISA Kits) and IL-8 (show IL8 ELISA Kits) was increased more by GRP (show LSM4 ELISA Kits) treatment.
GRP (show LSM4 ELISA Kits) serum level is higher in patients with pruritus in patients with atopic dermatitis.
GRP may be important both in the endometrial remodeling during the estrous cycle and in the implantation and development of blastocysts
The present results revealed the localization of GRP in the uterine gland cells at light- and electron-microscopic levels and suggested the release of GRP from the cell into the lumen of the gland by exocrine manner.
GRP may be important both in the development of the fetal cervix and secretory activity of the epithelial cells of the cervix.
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
, neuromedin C
, pre-progastrin releasing peptide
, proventricular peptide
, submandibular gland secretory Glx-rich protein
, uncharacterized protein LOC232426
, Gla-rich protein
, unique cartilage matrix-associated protein