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Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
The data demonstrate that KLF13 (show KLF13 Proteins) is an important component of the transcription network required for heart development and suggest that KLF13 (show KLF13 Proteins) is a GATA-4 modifier
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.
We confirmed the significance of the HNF1B (show HNF1B Proteins) and GATA4 hypermethylation with emphasis on the need of selecting the most relevant sites for analysis. We suggest selected CpGs to be further examined as a potential positive prognostic factor.
our results indicate that since high endogenous levels of transcription factor GATA4 likely protect hepatoblastoma cells from doxorubicin-induced apoptosis, these cells can be rendered more sensitive to the drug by downregulation of GATA4.
Subsequent functional analyses revealed that the transcriptional activity and Western blot of A167D mutant GATA4 protein were not altered in a Chinese Han population. These variants may be involved in other mechanisms underlying Conotruncal heart defect (CTD) or may be unrelated to CTD occurrence.
Study demonstrated downregulation of expression of pancreatic master genes SOX9 (show SOX9 Proteins), FOXA2 (show FOXA2 Proteins), and GATA4 (2-, 5-, and 4-fold, respectively) and in PANC1 pancreatic cancer cell line stimulated with TGFbeta1 (show TGFB1 Proteins)
Mutations of GATA4 appear to be responsible for some cardiac septal defects. The aim of this work was to screen for mutations in the GATA4 gene in sample of Egyptian patients affected by isolated and non-isolated cardiac septal defects. Identified are two coding variants and four non-coding ones of GATA4 gene, but further confirmation study for familial segregation detection was recommended.
The definitive endoderm and foregut endoderm differentiation capabilities of Wnt (show WNT2 Proteins) pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 (show SOX17 Proteins) and FOXA2 (show FOXA2 Proteins) and those of the transcription activator GATA4 and the alpha-fetoprotein (AFP (show AFP Proteins)) gene, respectively.
NKX2.5 (show NKX2-5 Proteins) and GATA4 gene mutations might participate in the development of congenital heart disease and can promote bone marrow derived stroma cell differentiate into cardiomyocytes.
There was no evidence of a role for NKX2-5 (show NKX2-5 Proteins) and GATA4 CNV in fetal CHD (show CHDH Proteins); therefore, these CNV may not be common in fetal CHD (show CHDH Proteins) in China
results demonstrate that cGMP-PKG (show PRKG1 Proteins) signaling mediates transcriptional activity of GATA4 and links defective GATA4 and PKG (show PRKG1 Proteins)-1alpha mutations to the development of human heart disease.
This study showed that GATA4 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders.
investigation of genes regulated by GATA4, GATA6 (show GATA6 Proteins), and both in combination: studies in granulosa cells primed for luteinization
GATA-4 and C/EBPbeta (show CEBPB Proteins) are both required for FSH (show BRD2 Proteins) +/- IGF-I (show IGF1 Proteins) stimulation of the porcine steroidogenic acute regulatory protein (show STAR Proteins) gene promoter in homologous granulosa cell cultures.
The altered ratio of GATA4 to GATA6 (show GATA6 Proteins) after ovulation may allow GATA6 (show GATA6 Proteins) to enhance STAR mRNA accumulation.
Histone acetylation/methylation and DNA methylation (show HELLS Proteins) were both involved in regulating GATA4 expression, but Nkx2.5 (show NKX2-5 Proteins) expression was not regulated by DNA methylation (show HELLS Proteins). These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.
GATA4 acts as a negative regulator of Bsp (show KLK6 Proteins) expression in osteoblasts.
Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs (show NR2E3 Proteins) by negatively regulating the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway and positively regulating the cardiogenic TF Gata4
GATA4 and GATA6 (show GATA6 Proteins) are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 and GATA6 (show GATA6 Proteins) are also required for the expression of the receptors for prolactin (show PRL Proteins) and luteinizing hormone.
Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine (show CCL1 Proteins) signaling.
data support the concept that under physiological conditions microbiota stimulate Gata4, which suppresses Asbt (show SLC10A2 Proteins) expression
MITF (show MITF Proteins) interacts with BRG1 (show SMARCA4 Proteins) to promote GATA4 expression in cardiac hypertrophy.
Data show that three transcriptional factors Gata4, Mef2c (show MEF2C Proteins), and Tbx5 (show TBX5 Proteins) (abbreviated as GMT (show GAMT Proteins)) significantly improved murine embryonic stem cells (ESCs (show NR2E3 Proteins)) differentiated into cardiomyocytes.
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 and SF-1 (show SF1 Proteins) expression.
GATA4/6-mediated inhibition of hedgehog (show SHH Proteins) signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut (show GUSB Proteins) tube
The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS (show ETS1 Proteins) sites.
Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.
ATOH8, GATA4, and FOG2 associate in a single complex
gata4 gene regulates sdf1a (show CXCL12 Proteins) levels during early embryogenesis
mga restricts the normal levels of Gata4 required for heart tube looping.
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
Gata4 and Gata6 (show GATA6 Proteins) have distinct non-redundant functions in cardiac morphogenesis, but are redundant for an early step of liver development; and Gata4 and Gata6 (show GATA6 Proteins) are essential and non-redundant for liver growth following initial budding
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 (show GATA6 Proteins) or GATA6 (show GATA6 Proteins), suggesting redundancy in this family during myocardial development.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
GATA binding protein 4
, glutamyl-tRNA(Gln) amidotransferase subunit A
, GATA-4 zinc-finger transcription factor
, gata4 transcription factor
, GATA-4 transcription factor
, GATA-binding factor 4
, transcription factor GATA-4
, GATA-binding protein 4
, DNA-binding protein GATA-GT2
, transcription factor GATA4
, transcription factor xGATA-4