Browse our anti-RFWD2 (RFWD2) Antibodies

Full name:
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase Antibodies (RFWD2)
On are 77 Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) Antibodies from 16 different suppliers available. Additionally we are shipping RFWD2 Proteins (5) and RFWD2 Kits (4) and many more products for this protein. A total of 92 RFWD2 products are currently listed.
list all antibodies Gene Name GeneID UniProt
RFWD2 64326 Q8NHY2
RFWD2 26374 Q9R1A8
RFWD2 360860  

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anti-Human RFWD2 Antibodies:

anti-Mouse (Murine) RFWD2 Antibodies:

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Top referenced anti-RFWD2 Antibodies

  1. Human Polyclonal RFWD2 Primary Antibody for WB - ABIN1881747 : Li, Ohshiro, Reddy, Pakala, Lee, Zhang, Rayala, Kumar: E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 references for 1881747

  2. Human Polyclonal RFWD2 Primary Antibody for ELISA, WB - ABIN1450737 : Wertz, ORourke, Zhang, Dornan, Arnott, Deshaies, Dixit: Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. in Science (New York, N.Y.) 2004 (PubMed)

More Antibodies against RFWD2 Interaction Partners

Arabidopsis thaliana Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. DHU1 negatively regulates UV-B signaling via its direct interaction with COP1 and RUP1 (show SCGB1A1 Antibodies) (At5g52250).

  2. BBX21 is a pivotal component involved in the COP1-HY5 regulatory hub.

  3. Meanwhile, transcript levels of ABA biosynthesis genes are higher in cip1 (show CDKN1A Antibodies)-1 than in the wild-type. These results suggested that CIP1 (show CDKN1A Antibodies) is positively involved in ABA response.

  4. salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1.

  5. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  6. Data indicate a coordinated regulation of Arabidopsis proteins SHW1, COP1, and HY5 in seedling development.

  7. The COP1 role in CONSTANS protein degradation during photoperiodic flowering

  8. CSU2 interacts with COP1 via the coiled-coil domain association. CSU2 negatively regulates COP1 E3 ubiquitin ligase (show MUL1 Antibodies) activity. [COP1]

  9. propose that light perceived by phytochromes causes a switch in the ubiquitination activity of COP1/SPA2 from ubiquitinating downstream substrates to ubiquitinating SPA2, which subsequently causes a repression of COP1/SPA2 function

  10. CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis.

Mouse (Murine) Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Prenatal inactivation of Rfwd2 gene in the lung epithelium led to a striking halt in branching morphogenesis shortly after secondary branch formation.

  2. Study shows that post-translational regulation of the transcription factors ETV1 (show ETV1 Antibodies), ETV4 (show ETV4 Antibodies), and ETV5 (show ETV5 Antibodies) by the ubiquitin ligase (show RNF123 Antibodies) COP1 (also called RFWD2) in beta cells is critical for insulin (show INS Antibodies) secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin (show INS Antibodies) granule docking defects that were fully rescued by genetic deletion of Etv1 (show ETV1 Antibodies), Etv4 (show ETV4 Antibodies), and Etv5 (show ETV5 Antibodies).

  3. These results indicate that COP1 and Trib1 (show TRIB1 Antibodies) act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA Antibodies), and its ligase activity is crucial for leukemogenesis.

  4. COP1 physically interacted with PTP1B (show PTPN1 Antibodies) and suppressed PTP1B (show PTPN1 Antibodies) phosphatase activity as well as the association of PTP1B (show PTPN1 Antibodies) with IRbeta.

  5. Modulation of fatty acid synthase (show FASN Antibodies) degradation by concerted action of p38 MAP kinase (show MAPK14 Antibodies), E3 ligase COP1, and SH2 (show MYO15 Antibodies)-tyrosine phosphatase Shp2 (show PTPN11 Antibodies).

  6. the ubiquitin ligase (show RNF123 Antibodies) COP1 (also known as RFWD2) is a tumour suppressor that negatively regulates ETV1 (show ETV1 Antibodies), ETV4 (show ETV4 Antibodies) and ETV5 (show ETV5 Antibodies); ETV1 (show ETV1 Antibodies), which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1

  7. Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun (show JUN Antibodies) oncogenic activity.

  8. Rfwd2 is associated with acute lung injury

  9. description of a pathway in which Tribbles 3 (TRB3 (show TRIB3 Antibodies)) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC (show ACACA Antibodies)) in adipose tissue; TRB3 (show TRIB3 Antibodies) promoted ACC (show ACACA Antibodies) ubiquitination through an association with the E3 ubiquitin ligase (show MUL1 Antibodies) COP1

  10. Disruption of the COP1-mediated proteolysis by ionizing radiation leads to MTA1 (show MTA1 Antibodies) stabilization.

Human Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. In conclusion, miR (show MLXIP Antibodies)-214 functions as a tumor suppressor by regulating the RFWD2-p53 (show TP53 Antibodies) cascade, thus delivery of miR (show MLXIP Antibodies)-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53 (show TP53 Antibodies).

  2. the reduced expression of COP1 (show CARD16 Antibodies) and the upregulated expression of ETV1 (show ETV1 Antibodies) in RCC (show XRCC1 Antibodies) tissue samples, which was associated with a high tumor-node-metastasis stage of RCC (show XRCC1 Antibodies). Furthermore, the overexpression of COP1 (show CARD16 Antibodies) in the RCC (show XRCC1 Antibodies) ACHN (show LARP6 Antibodies) cells inhibited the migration and invasion of ACHN (show LARP6 Antibodies) cells, and downregulated ETV1 (show ETV1 Antibodies) and MMP7 (show MMP7 Antibodies) expression levels.

  3. COP1 (show CARD16 Antibodies) expression was an independent predictor of overall survival.

  4. the present study revealed that COP1 (show CARD16 Antibodies) plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes.

  5. COP1 (show CARD16 Antibodies) directly interacts with p27 (show PAK2 Antibodies) through a VP motif on p27 (show PAK2 Antibodies) and functions as an E3 ligase of p27 (show PAK2 Antibodies) to accelerate the ubiquitin-mediated degradation of p27 (show PAK2 Antibodies). COP1 (show CARD16 Antibodies)-p27 (show PAK2 Antibodies) axis deregulation is involved in tumorigenesis.

  6. COP1 (show CARD16 Antibodies) overexpression leads to the cytoplasmic distribution of p27 (show PAK2 Antibodies), thereby accelerating p27 (show PAK2 Antibodies) degradation.

  7. COP1 (show CARD16 Antibodies) negatively regulates ETV1 (show ETV1 Antibodies) in patients with triple-negative breast cancer.

  8. TRIB2 (show TRIB2 Antibodies) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC Antibodies)), COP1 (show CARD16 Antibodies) and Smad ubiquitination regulatory factor 1 (Smurf1 (show SMURF1 Antibodies)) reduced TCF4 (show TCF4 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) expression, and these effects could be enhanced by TRIB2 (show TRIB2 Antibodies).

  9. Phosphorylation of the ETS1 (show ETS1 Antibodies) and ETS2 (show ETS2 Antibodies) transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 (show CARD16 Antibodies) tumor suppressor protein (show TP53 Antibodies).

  10. while the role of COP1 (show CARD16 Antibodies) in malignancies is controversial, our current data support that COP1 (show CARD16 Antibodies) acts as a tumor suppressor in gastric cancer.

RFWD2 Antigen Profile

Antigen Summary

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

Alternative names and synonyms associated with RFWD2

  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2) antibody
  • ring finger and WD repeat domain 2 (Rfwd2) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (Rfwd2) antibody
  • ring finger and WD repeat domain 2 (RFWD2) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (rfwd2) antibody
  • ring finger and WD repeat domain 2-like 1 (Rfwd2l1) antibody
  • ring finger and WD repeat domain 2 (rfwd2) antibody
  • ring finger and WD repeat domain 2 (LOC100360800) antibody
  • E3 ubiquitin-protein ligase COP1 (COP1) antibody
  • AI316802 antibody
  • ATCOP1 antibody
  • C80879 antibody
  • cop1 antibody
  • DEETIOLATED MUTANT 340 antibody
  • DET340 antibody
  • EMB168 antibody
  • EMBRYO DEFECTIVE 168 antibody
  • FUS1 antibody
  • FUSCA 1 antibody
  • Rfwd2 antibody
  • RGD1304773 antibody
  • rnf200 antibody
  • T21L14.11 antibody
  • T21L14_11 antibody

Protein level used designations for RFWD2

E3 ubiquitin-protein ligase RFWD2 , RING finger and WD repeat domain protein 2 , RING finger protein 200 , constitutive photomorphogenesis protein 1 homolog , constitutive photomorphogenic protein (COP1) , hCOP1 , putative ubiquitin ligase COP1 , constitutive photomorphogenic protein 1 , mCOP1 , ring finger and WD repeat domain 2 , rp11-318c24.3 , ring finger and WD repeat domain 2-like 1

64326 Homo sapiens
26374 Mus musculus
360860 Rattus norvegicus
429072 Gallus gallus
457541 Pan troglodytes
480060 Canis lupus familiaris
519896 Bos taurus
548953 Xenopus (Silurana) tropicalis
689375 Rattus norvegicus
100158422 Xenopus laevis
100360800 Rattus norvegicus
100021432 Monodelphis domestica
100553769 Anolis carolinensis
100582328 Nomascus leucogenys
817857 Arabidopsis thaliana
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