Browse our RFWD2 Proteins (RFWD2)

Full name:
Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase Proteins (RFWD2)
On are 5 Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) Proteins from 3 different suppliers available. Additionally we are shipping RFWD2 Antibodies (75) and RFWD2 Kits (4) and many more products for this protein. A total of 88 RFWD2 products are currently listed.
list all proteins Gene Name GeneID UniProt
RFWD2 26374 Q9R1A8
Rat RFWD2 RFWD2 689375  
RFWD2 64326 Q8NHY2

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RFWD2 Proteins (RFWD2) by Origin

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More Proteins for RFWD2 Interaction Partners

Arabidopsis thaliana Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. BBX21 is a pivotal component involved in the COP1-HY5 regulatory hub.

  2. Meanwhile, transcript levels of ABA biosynthesis genes are higher in cip1 (show CDKN1A Proteins)-1 than in the wild-type. These results suggested that CIP1 (show CDKN1A Proteins) is positively involved in ABA response.

  3. salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1.

  4. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  5. Data indicate a coordinated regulation of Arabidopsis proteins SHW1, COP1, and HY5 in seedling development.

  6. The COP1 role in CONSTANS protein degradation during photoperiodic flowering

  7. CSU2 interacts with COP1 via the coiled-coil domain association. CSU2 negatively regulates COP1 E3 ubiquitin ligase (show MUL1 Proteins) activity. [COP1]

  8. propose that light perceived by phytochromes causes a switch in the ubiquitination activity of COP1/SPA2 from ubiquitinating downstream substrates to ubiquitinating SPA2, which subsequently causes a repression of COP1/SPA2 function

  9. CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis.

  10. genetic analyses with transgenes expressing a genomic pmARI12:ARI12-GFP construct confirm the epistatic interaction between COP1 and ARI12 in growth responses to high fluence rate UV-B.

Mouse (Murine) Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Prenatal inactivation of Rfwd2 gene in the lung epithelium led to a striking halt in branching morphogenesis shortly after secondary branch formation.

  2. Study shows that post-translational regulation of the transcription factors ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins), and ETV5 (show ETV5 Proteins) by the ubiquitin ligase (show RNF123 Proteins) COP1 (also called RFWD2) in beta cells is critical for insulin (show INS Proteins) secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin (show INS Proteins) granule docking defects that were fully rescued by genetic deletion of Etv1 (show ETV1 Proteins), Etv4 (show ETV4 Proteins), and Etv5 (show ETV5 Proteins).

  3. These results indicate that COP1 and Trib1 (show TRIB1 Proteins) act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA Proteins), and its ligase activity is crucial for leukemogenesis.

  4. COP1 physically interacted with PTP1B (show PTPN1 Proteins) and suppressed PTP1B (show PTPN1 Proteins) phosphatase activity as well as the association of PTP1B (show PTPN1 Proteins) with IRbeta.

  5. Modulation of fatty acid synthase (show FASN Proteins) degradation by concerted action of p38 MAP kinase (show MAPK14 Proteins), E3 ligase COP1, and SH2-tyrosine phosphatase Shp2 (show PTPN11 Proteins).

  6. the ubiquitin ligase (show RNF123 Proteins) COP1 (also known as RFWD2) is a tumour suppressor that negatively regulates ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins) and ETV5 (show ETV5 Proteins); ETV1 (show ETV1 Proteins), which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1

  7. Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun (show JUN Proteins) oncogenic activity.

  8. Rfwd2 is associated with acute lung injury

  9. description of a pathway in which Tribbles 3 (TRB3 (show TRIB3 Proteins)) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC) in adipose tissue; TRB3 (show TRIB3 Proteins) promoted ACC ubiquitination through an association with the E3 ubiquitin ligase (show MUL1 Proteins) COP1

  10. Disruption of the COP1-mediated proteolysis by ionizing radiation leads to MTA1 (show MTA1 Proteins) stabilization.

Human Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. In conclusion, miR (show MLXIP Proteins)-214 functions as a tumor suppressor by regulating the RFWD2-p53 (show TP53 Proteins) cascade, thus delivery of miR (show MLXIP Proteins)-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53 (show TP53 Proteins).

  2. the reduced expression of COP1 (show CARD16 Proteins) and the upregulated expression of ETV1 (show ETV1 Proteins) in RCC (show XRCC1 Proteins) tissue samples, which was associated with a high tumor-node-metastasis stage of RCC (show XRCC1 Proteins). Furthermore, the overexpression of COP1 (show CARD16 Proteins) in the RCC (show XRCC1 Proteins) ACHN (show LARP6 Proteins) cells inhibited the migration and invasion of ACHN (show LARP6 Proteins) cells, and downregulated ETV1 (show ETV1 Proteins) and MMP7 (show MMP7 Proteins) expression levels.

  3. COP1 (show CARD16 Proteins) expression was an independent predictor of overall survival.

  4. the present study revealed that COP1 (show CARD16 Proteins) plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes.

  5. COP1 (show CARD16 Proteins) directly interacts with p27 (show PAK2 Proteins) through a VP motif on p27 (show PAK2 Proteins) and functions as an E3 ligase of p27 (show PAK2 Proteins) to accelerate the ubiquitin-mediated degradation of p27 (show PAK2 Proteins). COP1 (show CARD16 Proteins)-p27 (show PAK2 Proteins) axis deregulation is involved in tumorigenesis.

  6. COP1 (show CARD16 Proteins) overexpression leads to the cytoplasmic distribution of p27 (show PAK2 Proteins), thereby accelerating p27 (show PAK2 Proteins) degradation.

  7. COP1 (show CARD16 Proteins) negatively regulates ETV1 (show ETV1 Proteins) in patients with triple-negative breast cancer.

  8. TRIB2 (show TRIB2 Proteins) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC Proteins)), COP1 (show CARD16 Proteins) and Smad ubiquitination regulatory factor 1 (Smurf1 (show SMURF1 Proteins)) reduced TCF4 (show TCF4 Proteins)/beta-Catenin (show CTNNB1 Proteins) expression, and these effects could be enhanced by TRIB2 (show TRIB2 Proteins).

  9. Phosphorylation of the ETS1 (show ETS1 Proteins) and ETS2 (show ETS2 Proteins) transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 (show CARD16 Proteins) tumor suppressor protein (show TP53 Proteins).

  10. while the role of COP1 (show CARD16 Proteins) in malignancies is controversial, our current data support that COP1 (show CARD16 Proteins) acts as a tumor suppressor in gastric cancer.

RFWD2 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

Alternative names and synonyms associated with RFWD2

  • E3 ubiquitin-protein ligase COP1 (COP1)
  • ring finger and WD repeat domain 2 (Rfwd2)
  • ring finger and WD repeat domain 2-like 1 (Rfwd2l1)
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2)
  • AI316802 protein
  • ATCOP1 protein
  • C80879 protein
  • COP1 protein
  • DEETIOLATED MUTANT 340 protein
  • DET340 protein
  • EMB168 protein
  • EMBRYO DEFECTIVE 168 protein
  • FUS1 protein
  • FUSCA 1 protein
  • Rfwd2 protein
  • RNF200 protein
  • T21L14.11 protein
  • T21L14_11 protein

Protein level used designations for RFWD2

E3 ubiquitin-protein ligase RFWD2 , RING finger and WD repeat domain protein 2 , constitutive photomorphogenesis protein 1 homolog , constitutive photomorphogenic protein 1 , mCOP1 , ring finger and WD repeat domain 2-like 1 , ring finger and WD repeat domain 2 , RING finger protein 200 , constitutive photomorphogenic protein (COP1) , hCOP1 , putative ubiquitin ligase COP1

817857 Arabidopsis thaliana
26374 Mus musculus
689375 Rattus norvegicus
64326 Homo sapiens
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