Browse our anti-BIM (BCL2L11) Antibodies

Full name:
anti-BCL2-Like 11 (Apoptosis Facilitator) Antibodies (BCL2L11)
On www.antibodies-online.com are 339 BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Antibodies from 30 different suppliers available. Additionally we are shipping BIM Kits (19) and BIM Proteins (12) and many more products for this protein. A total of 390 BIM products are currently listed.
Synonyms:
1500006F24Rik, BAM, Bim, BIMEL, BimL, Bod
list all antibodies Gene Name GeneID UniProt
BCL2L11 10018 O43521
BCL2L11 12125 O54918
BCL2L11 64547 O88498

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Most Popular Reactivities for anti-BIM (BCL2L11) Antibodies

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anti-Human BIM Antibodies:

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anti-Rat (Rattus) BIM Antibodies:

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Top referenced anti-BIM Antibodies

  1. Human Polyclonal BIM Primary Antibody for IHC (p), WB - ABIN388101 : Chen, Zhou: Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 6 references for 388101

  2. Human Polyclonal BIM Primary Antibody for WB - ABIN967649 : Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 6 references for 967649

  3. Human Polyclonal BIM Primary Antibody for WB - ABIN222941 : Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007 (PubMed)
    Show all 3 references for 222941

  4. Human Polyclonal BIM Primary Antibody for IF, WB - ABIN264887 : Hsu, Lin, Hsueh: BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. in Molecular endocrinology (Baltimore, Md.) 1998 (PubMed)
    Show all 2 references for 264887

  5. Human Polyclonal BIM Primary Antibody for ELISA, WB - ABIN250248 : Jiang, Lucas, Avery-Kiejda, Wade, deBock, Thorne, Allen, Hersey, Zhang: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. in Cancer research 2008 (PubMed)
    Show all 2 references for 250248

  6. Human Polyclonal BIM Primary Antibody for IHC (fro), WB - ABIN264852 : OConnor, Strasser, OReilly, Hausmann, Adams, Cory, Huang: Bim: a novel member of the Bcl-2 family that promotes apoptosis. in The EMBO journal 1998 (PubMed)
    Show all 2 references for 264852

  7. Human Polyclonal BIM Primary Antibody for EIA, WB - ABIN453531 : Putcha, Le, Frank, Besirli, Clark, Chu, Alix, Youle, LaMarche, Maroney, Johnson: JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. in Neuron 2003 (PubMed)
    Show all 2 references for 453531

  8. Human Polyclonal BIM Primary Antibody for FACS, IHC (p) - ABIN652493 : Hippe, Weber, Zhou, Chang, Häcker, Lüder: Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax. in Journal of cell science 2009 (PubMed)
    Show all 2 references for 652493

  9. Human Polyclonal BIM Primary Antibody for IF (p), IHC (p) - ABIN682873 : Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. in The Journal of biological chemistry 2013 (PubMed)

  10. Human Polyclonal BIM Primary Antibody for WB - ABIN374444 : Marani, Tenev, Hancock, Downward, Lemoine: Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. in Molecular and cellular biology 2002 (PubMed)

More Antibodies against BIM Interaction Partners

Zebrafish BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Cloning and functional analysis of the bim gene.

Human BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2 (show PON2 Antibodies)) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (show ROS1 Antibodies)) production and induces Bim protein production that inhibits cancer progression via the PON2 (show PON2 Antibodies)-Bim cascade.

  2. Little difference in Bim expression among CD20 (show MS4A1 Antibodies)+ cells was seen between tonsil primary follicles, tonsil germinal centers, and lupus nephritis renal tissue. The frequency of Bim-positive cells among CD4 (show CD4 Antibodies)+ lymphocytes was significantly lower in lupus nephritis kidneys compared to tonsil controls.

  3. Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Antibodies) phosphorylation leads to decreased expression of c-MYC (show MYC Antibodies) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Antibodies) family member PUMA (show BBC3 Antibodies), whereas inhibition of mTORC2 (show CRTC2 Antibodies) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Antibodies)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.

  4. miR (show MLXIP Antibodies)-423-3p activates oncogenic and Beclin-1 (show BECN1 Antibodies)-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR (show MLXIP Antibodies)-423-3p-Bim axis might be a potential therapeutic target in GC.

  5. activation of the PI3K (show PIK3CA Antibodies) pathway does not suppress activation of the ARF (show CDKN2A Antibodies) or BIM gene by over-expressed E2F1 (show E2F1 Antibodies)

  6. have shown that Bim protein expression in CM is an independent predictor for advanced disease confirming that this pro-apoptotic BH3-only (show BBC3 Antibodies) protein might be a potent biomarker and promising therapeutic target

  7. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

  8. BIM deletion polymorphism does not account for intrinsic resistance to EGFR (show EGFR Antibodies)-TKI in Patients With Lung Adenocarcinoma

  9. Mechanistically, G-Rg1 (show PPP1R3A Antibodies) promoted the phosphorylation of Akt (show AKT1 Antibodies) and FoxO3a (show FOXO3 Antibodies) and led to the cytoplasmic translocation of FoxO3a (show FOXO3 Antibodies), which in turn suppressed FoxO3a (show FOXO3 Antibodies)-modulated expression of proapoptotic Bim and elevated the ratio of Bcl-2 (show BCL2 Antibodies) to Bax (show BAX Antibodies).

  10. Dnd1 (show DND1 Antibodies) facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR (show MLXIP Antibodies)-221 in Bim-3'UTR (show UTS2R Antibodies).

Mouse (Murine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.

  2. loss of the BH3-only (show BBC3 Antibodies) protein BIM accelerated lymphoma development in p53 (show TP53 Antibodies)-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 Antibodies)/2-mediated antigen receptor gene rearrangement.

  3. Overexpression of miR (show MLXIP Antibodies)-29 or miR (show MLXIP Antibodies)-24 is sufficient to inhibit the induction of Bim and Puma (show BBC3 Antibodies) in young sympathetic neurons.

  4. the activation of ERK5 (show MAPK7 Antibodies)-AKT (show AKT1 Antibodies)-FoxO3a (show FOXO3 Antibodies) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL Antibodies) and Bim and an inhibition of caspase-3 (show CASP3 Antibodies) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  5. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

  6. Results indicate that upregulation of miR (show MLXIP Antibodies)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Antibodies) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons

  7. Rapid activation of AMPK (show PRKAA1 Antibodies) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Antibodies) activation but not increased intracellular AMP (show TMPRSS5 Antibodies) levels or CaMKKbeta activation.

  8. Fluorizoline bind to prohibitin (show PHB Antibodies), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Antibodies) and BIM upregulation.

  9. Consistent with a contribution of BCL2 (show BCL2 Antibodies) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase

  10. The current study demonstrated that the BH3-only (show BBC3 Antibodies) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.

Pig (Porcine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Antibodies)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Antibodies)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.

  2. BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Antibodies).

  3. It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.

BIM (BCL2L11) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Alternative names and synonyms associated with BIM (BCL2L11)

  • BCL2-like 11 (bcl2l11) antibody
  • BCL2-like 11 (LOC100345483) antibody
  • BCL2-like 11 (apoptosis facilitator) (BCL2L11) antibody
  • BCL2-like 11 (apoptosis facilitator) (Bcl2l11) antibody
  • 1500006F24Rik antibody
  • BAM antibody
  • Bim antibody
  • BIMEL antibody
  • BimL antibody
  • Bod antibody

Protein level used designations for BCL2L11

BCL2-like 11 , Bcl-2 interacting mediator of cell death , bcl-2 interacting mediator of cell death , bcl-2 interacting protein Bim , bcl-2-like protein 11 , bcl-2-related ovarian death agonist , Bcl2 interacting mediator of cell death , bcl2-L-11 , bcl2-interacting mediator of cell death , Bcl-2 related apoptotic gene product BimL , bcl-2-related ovarian death protein

GENE ID SPECIES
100190951 Danio rerio
100345483 Oryctolagus cuniculus
10018 Homo sapiens
12125 Mus musculus
64547 Rattus norvegicus
507390 Bos taurus
396632 Sus scrofa
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