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anti-Human BIM Antibodies:
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Human Polyclonal BIM Primary Antibody for ELISA, IHC - ABIN4284640
Zhang, Gillespie, Borrow, Hersey: The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. in Molecular cancer therapeutics 2004
Show all 7 Pubmed References
Human Polyclonal BIM Primary Antibody for WB - ABIN967649
Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998
Show all 6 Pubmed References
Human Polyclonal BIM Primary Antibody for WB - ABIN222941
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007
Show all 3 Pubmed References
Human Polyclonal BIM Primary Antibody for ELISA, WB - ABIN250248
Jiang, Lucas, Avery-Kiejda, Wade, deBock, Thorne, Allen, Hersey, Zhang: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. in Cancer research 2008
Show all 2 Pubmed References
Human BIM Primary Antibody for IHC - ABIN965668
Fukazawa, Noguchi, Masumi, Murakami, Uehara: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. in Molecular cancer therapeutics 2004
Show all 2 Pubmed References
Human Polyclonal BIM Primary Antibody for IHC - ABIN965669
Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. in Oncogene 2003
Show all 2 Pubmed References
Human Polyclonal BIM Primary Antibody for IF (p), IHC (p) - ABIN682873
Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. in The Journal of biological chemistry 2013
Human Polyclonal BIM Primary Antibody for IHC, IHC (p) - ABIN4284636
Cash, Gruber, Hartman, Henske, Simon: Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription. in Oncogene 2011
Human Polyclonal BIM Primary Antibody for IHC (p), WB - ABIN388101
Chen, Zhou: Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 6 Pubmed References
Cloning and functional analysis of the bim gene.
sequestration of Bim by Mcl-1 (show MCL1 Antibodies) is a mechanism of intrinsic ABT-199 resistance and supports the clinical development of ABT-199 in combination with cytarabine or daunorubicin for the treatment of AML (show RUNX1 Antibodies).
Knock down of VDR (show CYP27B1 Antibodies) and BIM reduces the enhancement of cell death treated with Cytarabine (AraC) followed by the addition of Doxercalciferol together with Carnosic acid (CA).
UMI-77 enhances TRAIL-induced apoptosis by unsequestering Bim and Bak (show BAK1 Antibodies), which provides a novel therapeutic strategy for the treatment of gliomas.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak (show BAK1 Antibodies) through Structure-Based Design.
in FOXO3 (show FOXO3 Antibodies)-death-resistant cells no point mutations in the TP53 (show TP53 Antibodies)-DBD were found-in these cells FOXO3 (show FOXO3 Antibodies)-TP53 (show TP53 Antibodies) complexes are formed and FOXO3 (show FOXO3 Antibodies)-binding to the BIM-promoter, but not the induction of the detoxifying protein SESN3 (show SESN3 Antibodies), were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (show ARHGEF16 Antibodies) cells
At BCL2L11, the authors identify a haematopoietic enhancer hub that is inactivated by the Epstein-Barr virus repressors EBNA3A (show EBNA-3A Antibodies) and EBNA3C through recruitment of the H3K27 methyltransferase EZH2 (show EZH2 Antibodies).
observations suggest that an association of a deletion polymorphism of BIM and the response to induction therapy in B-cell precursor acute lymphoblastic leukemia may be clinically minimal
expression of Bim is mediated by FoxO1 (show FOXO1 Antibodies) and indirectly downregulated by thyroid hormone/thyroid hormone (show PTH Antibodies) receptor (show THRA Antibodies), leading to chemotherapy resistance and doxorubicin-promoted metastasis of hepatoma cells.
BIM is associated with favorable prognostic markers for prediction of disease-free survival and overall survival in cervical cancer.
this study shows that BIM deletion polymorphisms are associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients with EGFR (show EGFR Antibodies) positive non-small-cell lung cancer
Bcl2l11 as the direct target of miR (show MLXIP Antibodies)-9 and manipulation of miR (show MLXIP Antibodies)-9 induces the corresponding changing of Bcl2l11 protein level.
these data suggest that the Bim may be a novel therapeutic target in the treatment of systemic lupus erythematosus.
Data show that the induction of BIM in the MYC (show MYC Antibodies)- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL).
Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction.
understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision
The central role of Bim-dependent apoptosis in Buruli Ulcer pathogenesis
we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.
loss of the BH3-only (show BBC3 Antibodies) protein BIM accelerated lymphoma development in p53 (show TP53 Antibodies)-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 Antibodies)/2-mediated antigen receptor gene rearrangement.
Overexpression of miR (show MLXIP Antibodies)-29 or miR (show MLXIP Antibodies)-24 is sufficient to inhibit the induction of Bim and Puma (show BBC3 Antibodies) in young sympathetic neurons.
Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Antibodies)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Antibodies)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Antibodies).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein