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Browse our BIM Proteins (BCL2L11)

Full name:
BCL2-Like 11 (Apoptosis Facilitator) Proteins (BCL2L11)
On are 12 BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Proteins from 7 different suppliers available. Additionally we are shipping BIM Antibodies (331) and BIM Kits (14) and many more products for this protein. A total of 377 BIM products are currently listed.
1500006F24Rik, BAM, Bim, BIMEL, BimL, Bod
list all proteins Gene Name GeneID UniProt
BCL2L11 10018 O43521
BCL2L11 12125 O54918
BCL2L11 64547 O88498

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BIM Proteins (BCL2L11) by Origin

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Top referenced BIM Proteins

  1. Human BIM Protein expressed in Escherichia coli (E. coli) - ABIN1098664 : Liu, Chandra, Tang, Chopra, Tang: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. in Cancer research 2002 (PubMed)
    Show all 2 references for ABIN1098664

More Proteins for BIM Interaction Partners

Zebrafish BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Cloning and functional analysis of the bim gene.

Human BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. patients with BIM-g had significantly shorter progression-free survival than those without BIM-gamma (median: 304 vs. 732 days; p=0.023). CONCLUSION: Expression of BIM-gamma mRNA and BIM deletion polymorphism were strongly associated. BIM-gamma overexpression may have a role in apoptosis related to EGFR (show EGFR Proteins)-tyrosine kinase (show TXK Proteins) inhibitor

  2. MicroRNA-301b directly targets the expression of Bim, a well-known pro-apoptotic protein.

  3. FOXO4 (show FOXO4 Proteins) has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim in the mitochondria-dependent pathway.

  4. Results indicate that upregulation of miR (show MLXIP Proteins)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Proteins) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons

  5. the Bim activated by doxorubicin-induced DNA damage might directly interrupt the interaction of Bcl-xl (show BCL2L1 Proteins) with pro-apoptotic proteins, Bak (show BAK1 Proteins)/Bax (show BAX Proteins), to activate mitochondriadriven apoptosis.

  6. the BIM deletion polymorphism enhanced the emergence of populations with complete imatinib resistance, mimicking the situation in patients.

  7. BimEL-Bax pro-apoptotic cascade is activated by cAMP signalling of Bordetella adenylate cyclase toxin through SHP-1 phosphatase in phagocytes.

  8. miR (show MLXIP Proteins)-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of gastric cancer

  9. The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 (show BCL2 Proteins) and cyclin D expression and upregulation of BAX (show BAX Proteins) and Bim expression.

  10. mRNA expression of BIM and MTOR (show FRAP1 Proteins) in 57 patients with EGFR (show EGFR Proteins)-mutant non-small-cell lung cancer.

Mouse (Murine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Results indicate that upregulation of miR (show MLXIP Proteins)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Proteins) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons

  2. Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  3. Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM upregulation.

  4. Consistent with a contribution of BCL2 (show BCL2 Proteins) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase

  5. The current study demonstrated that the BH3-only (show BBC3 Proteins) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.

  6. Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf (show BMF Proteins)), mediate apoptosis in the context of TACI (show TNFRSF13B Proteins)-Ig overexpression that effectively neutralizes BAFF (show TNFSF13B Proteins) as well as APRIL.

  7. these results indicate that 1alpha,25(OH)2D3 and TX 527 trigger apoptosis by Bim protein increase which turns into the activation of caspase-3 (show CASP3 Proteins) in SVEC and vGPCR cells

  8. miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  9. The findings reveal an essential role for TRIM33 (show TRIM33 Proteins) in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation.

  10. BIM deficiency prevents diabetes in NOD mice by diverting thymocytes to Treg cells via reduced thymic deletion.

Pig (Porcine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Proteins)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Proteins)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.

  2. BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Proteins).

  3. It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.

BIM (BCL2L11) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Alternative names and synonyms associated with BIM (BCL2L11)

  • BCL2-like 11 (bcl2l11)
  • BCL2-like 11 (LOC100345483)
  • BCL2-like 11 (apoptosis facilitator) (BCL2L11)
  • BCL2-like 11 (apoptosis facilitator) (Bcl2l11)
  • 1500006F24Rik protein
  • BAM protein
  • Bim protein
  • BIMEL protein
  • BimL protein
  • Bod protein

Protein level used designations for BCL2L11

BCL2-like 11 , Bcl-2 interacting mediator of cell death , bcl-2 interacting mediator of cell death , bcl-2 interacting protein Bim , bcl-2-like protein 11 , bcl-2-related ovarian death agonist , Bcl2 interacting mediator of cell death , bcl2-L-11 , bcl2-interacting mediator of cell death , Bcl-2 related apoptotic gene product BimL , bcl-2-related ovarian death protein

100190951 Danio rerio
100345483 Oryctolagus cuniculus
10018 Homo sapiens
12125 Mus musculus
64547 Rattus norvegicus
507390 Bos taurus
396632 Sus scrofa
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