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Human BIM Protein expressed in Escherichia coli (E. coli) - ABIN1098664
Liu, Chandra, Tang, Chopra, Tang: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. in Cancer research 2002
Show all 2 references for ABIN1098664
Cloning and functional analysis of the bim gene.
FOXO4 (show FOXO4 Proteins) has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim in the mitochondria-dependent pathway.
Results indicate that upregulation of miR (show MLXIP Proteins)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Proteins) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons
the Bim activated by doxorubicin-induced DNA damage might directly interrupt the interaction of Bcl-xl (show BCL2L1 Proteins) with pro-apoptotic proteins, Bak (show BAK1 Proteins)/Bax (show BAX Proteins), to activate mitochondriadriven apoptosis.
the BIM deletion polymorphism enhanced the emergence of populations with complete imatinib resistance, mimicking the situation in patients.
BimEL-Bax pro-apoptotic cascade is activated by cAMP signalling of Bordetella adenylate cyclase toxin through SHP-1 phosphatase in phagocytes.
miR (show MLXIP Proteins)-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of gastric cancer
The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 (show BCL2 Proteins) and cyclin D expression and upregulation of BAX (show BAX Proteins) and Bim expression.
mRNA expression of BIM and MTOR (show FRAP1 Proteins) in 57 patients with EGFR (show EGFR Proteins)-mutant non-small-cell lung cancer.
miR (show MLXIP Proteins)-24 promotes tumor growth and angiogenesis by suppressing Bim expression in a model of pancreatic carcinoma
miR (show MLXIP Proteins)-181b/Bim pathway may be a novel target used to overcome the chemoresistance in breast cancer
Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.
Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM upregulation.
Consistent with a contribution of BCL2 (show BCL2 Proteins) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase
The current study demonstrated that the BH3-only (show BBC3 Proteins) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.
Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf (show BMF Proteins)), mediate apoptosis in the context of TACI (show TNFRSF13B Proteins)-Ig overexpression that effectively neutralizes BAFF (show TNFSF13B Proteins) as well as APRIL.
these results indicate that 1alpha,25(OH)2D3 and TX 527 trigger apoptosis by Bim protein increase which turns into the activation of caspase-3 (show CASP3 Proteins) in SVEC and vGPCR cells
miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
The findings reveal an essential role for TRIM33 (show TRIM33 Proteins) in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation.
BIM deficiency prevents diabetes in NOD mice by diverting thymocytes to Treg cells via reduced thymic deletion.
Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Proteins)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Proteins)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Proteins).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein