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Cloning and functional analysis of the bim gene.
expression of Bim is mediated by FoxO1 (show FOXO1 Proteins) and indirectly downregulated by thyroid hormone/thyroid hormone (show PTH Proteins) receptor (show THRA Proteins), leading to chemotherapy resistance and doxorubicin-promoted metastasis of hepatoma cells.
BIM is associated with favorable prognostic markers for prediction of disease-free survival and overall survival in cervical cancer.
this study shows that BIM deletion polymorphisms are associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients with EGFR (show EGFR Proteins) positive non-small-cell lung cancer
The Bim deletion polymorphism was found to be associated with primary resistance to crizotinib in patients with ALK fusion-positive NSCLC.
increased apoptosis resistance was associated with significantly reduced up-regulation of proapoptotic Bim in T cells from patients with primary sclerosing cholangitis.
Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2 (show PON2 Proteins)) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (show ROS1 Proteins)) production and induces Bim protein production that inhibits cancer progression via the PON2 (show PON2 Proteins)-Bim cascade.
Little difference in Bim expression among CD20 (show MS4A1 Proteins)+ cells was seen between tonsil primary follicles, tonsil germinal centers, and lupus nephritis renal tissue. The frequency of Bim-positive cells among CD4 (show CD4 Proteins)+ lymphocytes was significantly lower in lupus nephritis kidneys compared to tonsil controls.
Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Proteins) phosphorylation leads to decreased expression of c-MYC (show MYC Proteins) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Proteins) family member PUMA (show BBC3 Proteins), whereas inhibition of mTORC2 (show CRTC2 Proteins) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Proteins)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.
miR (show MLXIP Proteins)-423-3p activates oncogenic and Beclin-1 (show BECN1 Proteins)-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR (show MLXIP Proteins)-423-3p-Bim axis might be a potential therapeutic target in GC.
activation of the PI3K (show PIK3CA Proteins) pathway does not suppress activation of the ARF or BIM gene by over-expressed E2F1 (show E2F1 Proteins)
Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction.
understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision
The central role of Bim-dependent apoptosis in Buruli Ulcer pathogenesis
we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.
loss of the BH3-only (show BBC3 Proteins) protein BIM accelerated lymphoma development in p53 (show TP53 Proteins)-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 Proteins)/2-mediated antigen receptor gene rearrangement.
Overexpression of miR (show MLXIP Proteins)-29 or miR (show MLXIP Proteins)-24 is sufficient to inhibit the induction of Bim and Puma (show BBC3 Proteins) in young sympathetic neurons.
the activation of ERK5 (show MAPK7 Proteins)-AKT (show AKT1 Proteins)-FoxO3a (show FOXO3 Proteins) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL Proteins) and Bim and an inhibition of caspase-3 (show CASP3 Proteins) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.
long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Results indicate that upregulation of miR (show MLXIP Proteins)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Proteins) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons
Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.
Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Proteins)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Proteins)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Proteins).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein