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Human BIM Protein expressed in Escherichia coli (E. coli) - ABIN1098664
Liu, Chandra, Tang, Chopra, Tang: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. in Cancer research 2002
Show all 2 references for ABIN1098664
Cloning and functional analysis of the bim gene.
miR (show MLXIP Proteins)-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of gastric cancer
The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 (show BCL2 Proteins) and cyclin D expression and upregulation of BAX (show BAX Proteins) and Bim expression.
mRNA expression of BIM and MTOR (show FRAP1 Proteins) in 57 patients with EGFR (show EGFR Proteins)-mutant non-small-cell lung cancer.
miR (show MLXIP Proteins)-24 promotes tumor growth and angiogenesis by suppressing Bim expression in a model of pancreatic carcinoma
miR (show MLXIP Proteins)-181b/Bim pathway may be a novel target used to overcome the chemoresistance in breast cancer
Bcl-2 (show BCL2 Proteins) dependent NB cell lines are exquisitely sensitive to ABT-199 . Treatment with ABT-199 displaces Bim from Bcl-2 (show BCL2 Proteins) in NB to activate caspase 3 (show CASP3 Proteins), confirming the restoration of mitochondrial apoptosis
Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM upregulation.
LA provoked a down regulation of two anti-apoptotic proteins, Mcl-1 (show MCL1 Proteins) and Bcl-xL (show BCL2L1 Proteins) protein and a strong induction of the BH3-only (show BBC3 Proteins) protein Bim.
JNK/c-Jun activation and BIM induction is a late pro-apoptotic response of glioma cells treated with alkylating anticancer drugs.
analysis of the intricate network regulating Bim activity and its involvement in physiological and pathophysiological processes [review]
Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.
Consistent with a contribution of BCL2 (show BCL2 Proteins) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase
The current study demonstrated that the BH3-only (show BBC3 Proteins) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.
Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf (show BMF Proteins)), mediate apoptosis in the context of TACI (show TNFRSF13B Proteins)-Ig overexpression that effectively neutralizes BAFF (show TNFSF13B Proteins) as well as APRIL.
these results indicate that 1alpha,25(OH)2D3 and TX 527 trigger apoptosis by Bim protein increase which turns into the activation of caspase-3 (show CASP3 Proteins) in SVEC and vGPCR cells
miR (show MLXIP Proteins)-155 regulates the delicate balance between PAK1 (show PAK1 Proteins)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
The findings reveal an essential role for TRIM33 (show TRIM33 Proteins) in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation.
BIM deficiency prevents diabetes in NOD mice by diverting thymocytes to Treg cells via reduced thymic deletion.
with age, enhanced ICOS (show ICOS Proteins) expression on eTregs likely limits Bim expression via activation of the PI3K/Akt (show AKT1 Proteins)/FOXO (show FOXO3 Proteins) pathway, promoting eTreg survival.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Proteins).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein