Browse our BIM Proteins (BCL2L11)

Full name:
BCL2-Like 11 (Apoptosis Facilitator) Proteins (BCL2L11)
On are 12 BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Proteins from 7 different suppliers available. Additionally we are shipping BIM Antibodies (332) and BIM Kits (19) and many more products for this protein. A total of 383 BIM products are currently listed.
1500006F24Rik, BAM, Bim, BIMEL, BimL, Bod
list all proteins Gene Name GeneID UniProt
BCL2L11 10018 O43521
BCL2L11 12125 O54918
BCL2L11 64547 O88498

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BIM Proteins (BCL2L11) by Origin

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Top referenced BIM Proteins

  1. Human BIM Protein expressed in Escherichia coli (E. coli) - ABIN1098664 : Liu, Chandra, Tang, Chopra, Tang: Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. in Cancer research 2002 (PubMed)
    Show all 2 references for 1098664

More Proteins for BIM Interaction Partners

Zebrafish BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Cloning and functional analysis of the bim gene.

Human BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2 (show PON2 Proteins)) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (show ROS1 Proteins)) production and induces Bim protein production that inhibits cancer progression via the PON2 (show PON2 Proteins)-Bim cascade.

  2. Little difference in Bim expression among CD20 (show MS4A1 Proteins)+ cells was seen between tonsil primary follicles, tonsil germinal centers, and lupus nephritis renal tissue. The frequency of Bim-positive cells among CD4 (show CD4 Proteins)+ lymphocytes was significantly lower in lupus nephritis kidneys compared to tonsil controls.

  3. Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 Proteins) phosphorylation leads to decreased expression of c-MYC (show MYC Proteins) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 Proteins) family member PUMA (show BBC3 Proteins), whereas inhibition of mTORC2 (show CRTC2 Proteins) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (show EGR1 Proteins)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.

  4. miR (show MLXIP Proteins)-423-3p activates oncogenic and Beclin-1 (show BECN1 Proteins)-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR (show MLXIP Proteins)-423-3p-Bim axis might be a potential therapeutic target in GC.

  5. activation of the PI3K (show PIK3CA Proteins) pathway does not suppress activation of the ARF or BIM gene by over-expressed E2F1 (show E2F1 Proteins)

  6. have shown that Bim protein expression in CM is an independent predictor for advanced disease confirming that this pro-apoptotic BH3-only (show BBC3 Proteins) protein might be a potent biomarker and promising therapeutic target

  7. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

  8. BIM deletion polymorphism does not account for intrinsic resistance to EGFR (show EGFR Proteins)-TKI in Patients With Lung Adenocarcinoma

  9. Mechanistically, G-Rg1 (show PPP1R3A Proteins) promoted the phosphorylation of Akt (show AKT1 Proteins) and FoxO3a (show FOXO3 Proteins) and led to the cytoplasmic translocation of FoxO3a (show FOXO3 Proteins), which in turn suppressed FoxO3a (show FOXO3 Proteins)-modulated expression of proapoptotic Bim and elevated the ratio of Bcl-2 (show BCL2 Proteins) to Bax (show BAX Proteins).

  10. Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR.

Mouse (Murine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.

  2. loss of the BH3-only (show BBC3 Proteins) protein BIM accelerated lymphoma development in p53 (show TP53 Proteins)-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 Proteins)/2-mediated antigen receptor gene rearrangement.

  3. Overexpression of miR (show MLXIP Proteins)-29 or miR (show MLXIP Proteins)-24 is sufficient to inhibit the induction of Bim and Puma (show BBC3 Proteins) in young sympathetic neurons.

  4. the activation of ERK5 (show MAPK7 Proteins)-AKT (show AKT1 Proteins)-FoxO3a (show FOXO3 Proteins) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL Proteins) and Bim and an inhibition of caspase-3 (show CASP3 Proteins) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  5. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

  6. Results indicate that upregulation of miR (show MLXIP Proteins)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 Proteins) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons

  7. Rapid activation of AMPK (show PRKAA1 Proteins) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 Proteins) activation but not increased intracellular AMP (show TMPRSS5 Proteins) levels or CaMKKbeta activation.

  8. Fluorizoline bind to prohibitin (show PHB Proteins), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 Proteins) and BIM upregulation.

  9. Consistent with a contribution of BCL2 (show BCL2 Proteins) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase

  10. The current study demonstrated that the BH3-only (show BBC3 Proteins) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.

Pig (Porcine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) interaction partners

  1. Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 Proteins)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 Proteins)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.

  2. BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 Proteins).

  3. It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.

BIM (BCL2L11) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Alternative names and synonyms associated with BIM (BCL2L11)

  • BCL2-like 11 (bcl2l11)
  • BCL2-like 11 (LOC100345483)
  • BCL2-like 11 (apoptosis facilitator) (BCL2L11)
  • BCL2-like 11 (apoptosis facilitator) (Bcl2l11)
  • 1500006F24Rik protein
  • BAM protein
  • Bim protein
  • BIMEL protein
  • BimL protein
  • Bod protein

Protein level used designations for BCL2L11

BCL2-like 11 , Bcl-2 interacting mediator of cell death , bcl-2 interacting mediator of cell death , bcl-2 interacting protein Bim , bcl-2-like protein 11 , bcl-2-related ovarian death agonist , Bcl2 interacting mediator of cell death , bcl2-L-11 , bcl2-interacting mediator of cell death , Bcl-2 related apoptotic gene product BimL , bcl-2-related ovarian death protein

100190951 Danio rerio
100345483 Oryctolagus cuniculus
10018 Homo sapiens
12125 Mus musculus
64547 Rattus norvegicus
507390 Bos taurus
396632 Sus scrofa
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