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Human CDK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003156
Gu, Rosenblatt, Morgan: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. in The EMBO journal 1992
Show all 5 references for ABIN2003156
Human CDK2 Protein expressed in Escherichia coli (E. coli) - ABIN667950
Hannon, Casso, Beach: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 2 references for ABIN667950
Human CDK2 Protein expressed in Wheat germ - ABIN1348936
Molatore, Marinoni, Lee, Pulz, Ambrosio, degli Uberti, Zatelli, Pellegata: A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. in Human mutation 2010
evidence that cyclin A1 (show CCNA1 Proteins)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Proteins)/Cdk2 is sufficient to induce apoptosis
show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 (show CDKN1A Proteins) and CDK2.
our study reveals a novel function of CDK2 in EGF (show EGF Proteins)-induced cell transformation and the associated signal transduction pathways. This indicates that CDK2 is a useful molecular target for the chemoprevention and therapy against skin cancer.
Study describes a positive feedback loop centred on cyclin A2 (show CCNA2 Proteins)-Cdk2 inhibition of interphase APC (show APC Proteins)/C-Cdc20 (show CDC20 Proteins) to allow further cyclin A2 (show CCNA2 Proteins) accumulation and mitotic entry.
both cell lines feature a significant reduction of CDK2 expression verified at the RNA and protein level, respectively
ovary tumors with elevated CCNE1 (show CCNE1 Proteins) expression may be staged for Cdk2-targeted therapy
Centriolar satellites build a centrosomal microcephaly protein complex critical for human neurodevelopment that promotes CDK2 centrosomal localization and centriole duplication.
PIWIL2 has a role in promoting progression of non-small cell lung cancer by inducing CDK2 and Cyclin A (show CCNA2 Proteins) expression
In G28 cells, a dosedependent induction of CDK2, p21 and cyclin D was observed between 10 and 50 microM roscovitine after 72 h, however, at the highest concentration of 100 microM, all investigated genes were downregulated.
Identified ING5 (show ING5 Proteins) as a novel CDK2 substrate. ING5 (show ING5 Proteins) is phosphorylated at a single site, threonine 152, by cyclin E (show CCNE1 Proteins)/CDK2 and cyclin A (show CCNA2 Proteins)/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate.
RingoA (show SPDYA Proteins) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
Sox2 (show SOX2 Proteins) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.
Our data indicate that Cdk2 and Cdk4 (show CDK4 Proteins) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.
ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.
CDK4 (show CDK4 Proteins) is a critical downstream target of MEN1 (show MEN1 Proteins)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumorigenesis in these neuroendocrine cell types.
Our results highlight an important role for p-CDK2(39) in influencing silencing of the sex chromosomes during male meiosis by interacting with gamma-H2AX.
abnormal pairing and synapsis of homologous chromosomes, heterologous chromosome associations, unrepaired double-strand DNA breaks, disruptions in telomeric structure and defects in cyclin-dependent-kinase 2 localization
Results show that CDK2 phosphorylates Thr (show TRH Proteins)-156 in GATA3 (show GATA3 Proteins).
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.
PI3-kinase (show PIK3CA Proteins) and Akt (show AKT1 Proteins) participate in insulin (show INS Proteins) stimulation of p34cdc2 (show CDK1 Proteins) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Proteins) during early vertebrate development
cyclin D1 (show CCND1 Proteins), CDK2 and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, cell division protein kinase 2
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, cdc2-related protein kinase
, cell devision kinase 2
, p33 protein kinase
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2