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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006
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evidence that cyclin A1 (show CCNA1 Proteins)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Proteins)/Cdk2 is sufficient to induce apoptosis
Here, we introduce a transcriptional signature to specifically track CDK2 activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 Proteins)-RB-E2F (show E2F1 Proteins) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (show Cep76 Proteins)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2) and is a bona fide substrate of this kinase. Cep76 (show Cep76 Proteins) is preferentially phosphorylated by cyclin A (show CCNA2 Proteins)/CDK2 at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (show SPDYA Proteins) confers structural changes to Cdk2 that obviate the requirement of Cdk (show CDK4 Proteins) activation loop phosphorylation.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (show WEE1 Proteins) alone is inhibited, Chk1 (show CHEK1 Proteins) suppresses CDC45 (show CDC45 Proteins) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 Proteins)-activity.
Results show that cyclin E1 (show CCNE1 Proteins) and CDK2 participate in STC1 (show STC1 Proteins) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (show CDK1 Proteins) inhibition.
periodic phosphorylation of Ku70 (show XRCC6 Proteins) by cyclin-cyclin (show PCNA Proteins) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 binding, and attenuated E2F-1 (show E2F1 Proteins) sequestration.
These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (show CCNE1 Proteins)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (show CCNE1 Proteins) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (show PCNA Proteins) E1and cyclin E2 (show CCNE2 Proteins))and its associated kinase, Cdk2, in different mouse organs.
RingoA (show SPDYA Proteins) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
Sox2 (show SOX2 Proteins) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.
Our data indicate that Cdk2 and Cdk4 (show CDK4 Proteins) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.
PI3-kinase (show PIK3CA Proteins) and Akt (show AKT1 Proteins) participate in insulin (show INS Proteins) stimulation of p34cdc2 (show CDK1 Proteins) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Proteins) during early vertebrate development
cyclin D1 (show CCND1 Proteins), CDK2 and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (show ATM Proteins)-P53 (show TP53 Proteins)-P21 (show CDKN1A Proteins) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, cell division protein kinase 2
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, cdc2-related protein kinase
, cell devision kinase 2
, p33 protein kinase
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2