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Browse our CDK2 Proteins (CDK2)

Full name:
Cyclin-Dependent Kinase 2 Proteins (CDK2)
On are 34 Cyclin-Dependent Kinase 2 (CDK2) Proteins from 10 different suppliers available. Additionally we are shipping CDK2 Antibodies (353) and CDK2 Kits (37) and many more products for this protein. A total of 464 CDK2 products are currently listed.
A630093N05Rik, cdk2L, CDKN2, CINP, eg1, MGC84068, p33(CDK2), wu:fa10c02, zgc:56598, zgc:77684
list all proteins Gene Name GeneID UniProt
CDK2 362817  
CDK2 1017 P24941
CDK2 12566 P97377

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CDK2 Proteins (CDK2) by Origin

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Top referenced CDK2 Proteins

  1. Human CDK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003156 : Gu, Rosenblatt, Morgan: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. in The EMBO journal 1992 (PubMed)
    Show all 5 references for ABIN2003156

  2. Human CDK2 Protein expressed in Wheat germ - ABIN1348934 : Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006 (PubMed)
    Show all 2 references for ABIN1348934

  3. Human CDK2 Protein expressed in Escherichia coli (E. coli) - ABIN667950 : Hannon, Casso, Beach: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 2 references for ABIN667950

More Proteins for CDK2 Interaction Partners

Xenopus laevis Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. evidence that cyclin A1 (show CCNA1 Proteins)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Proteins)/Cdk2 is sufficient to induce apoptosis

Human Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. Dsg2 (show DSG2 Proteins) knockdown arrests non-small cell lung cancer cell cycle progression via modulation of p27 (show PAK2 Proteins)-CDK2 levels.

  2. CDK2 protects podocytes from apoptosis and reduced expression of CDK2 associates with the development of diabetic nephropathy.

  3. CDK2 controls a wide-spread epigenetic program that drives transcription at differentiation-related gene promoters specifically in G1. (Review)

  4. SATB2 (show SATB2 Proteins) regulates the mitosis of cell cycle and affects G1 cell cycle via interaction with CDK2.

  5. Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 or Cyclin A2 (show CCNA2 Proteins) knockdown. These findings support G2 exit as the more significant effect of Wee1 (show WEE1 Proteins) inhibition in pancreatic cancers.

  6. A novel link has been discussed between CDK2 expression and cell migration by characterizing the CDK2-mediated phosphorylation of BRMS1 (show BRMS1 Proteins).

  7. the results suggest that CK1delta activity can be modulated by the interplay between CK1delta and CDK2/E or CDK5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins).

  8. Inappropriate activation of CDK2 in S phase underlies the sensitivity of a subset of cell lines to Chk1 (show CHEK1 Proteins) inhibitors.

  9. CDK2 and DNA-PK regulate PR transcriptional activity by distinct mechanisms.

  10. The expression of cdk2 in malignancy of ovarian tumors.

Mouse (Murine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. RingoA (show SPDYA Proteins) is an important activator of Cdk2 at meiotic telomeres.

  2. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.

  3. Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.

  4. Sox2 (show SOX2 Proteins) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.

  5. Our data indicate that Cdk2 and Cdk4 (show CDK4 Proteins) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.

  6. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.

  7. CDK4 (show CDK4 Proteins) is a critical downstream target of MEN1 (show MEN1 Proteins)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumorigenesis in these neuroendocrine cell types.

  8. Our results highlight an important role for p-CDK2(39) in influencing silencing of the sex chromosomes during male meiosis by interacting with gamma-H2AX.

  9. abnormal pairing and synapsis of homologous chromosomes, heterologous chromosome associations, unrepaired double-strand DNA breaks, disruptions in telomeric structure and defects in cyclin-dependent-kinase 2 localization

  10. Results show that CDK2 phosphorylates Thr (show TRH Proteins)-156 in GATA3 (show GATA3 Proteins).

Zebrafish Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

  2. PI3-kinase (show PIK3CA Proteins) and Akt (show AKT1 Proteins) participate in insulin (show INS Proteins) stimulation of p34cdc2 (show CDK1 Proteins) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.

  3. an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Proteins) during early vertebrate development

Cow (Bovine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. cyclin D1 (show CCND1 Proteins), CDK2 and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

CDK2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

Alternative names and synonyms associated with CDK2

  • MGC84068 protein (MGC84068)
  • cyclin-dependent kinase 2 interacting protein (CINP)
  • Cyclin-dependent kinase 2-interacting protein (cinp)
  • cyclin dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (CDK2)
  • cyclin-dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (cdk2)
  • cyclin-dependent kinase 2 (CDK2) (Cdk2)
  • cyclin-dependent kinase-2 alpha (LOC100154715)
  • A630093N05Rik protein
  • cdk2L protein
  • CDKN2 protein
  • CINP protein
  • eg1 protein
  • MGC84068 protein
  • p33(CDK2) protein
  • wu:fa10c02 protein
  • zgc:56598 protein
  • zgc:77684 protein

Protein level used designations for CDK2

MGC84068 protein , Cyclin-dependent kinase 2-interacting protein , cyclin-dependent kinase 2 interacting protein , cyclin-dependent kinase 2-interacting protein , cell division protein kinase 2 , cyclin dependent kinase 2-alpha , cyclin-dependent kinase 2 , cdc2-related protein kinase , cell devision kinase 2 , p33 protein kinase , CDC2 homolog Eg1 protein kinase , Cell division protein kinase 2

444599 Xenopus laevis
744050 Pan troglodytes
100196126 Salmo salar
362817 Rattus norvegicus
1017 Homo sapiens
12566 Mus musculus
406715 Danio rerio
399314 Xenopus laevis
100529062 Gallus gallus
606931 Canis lupus familiaris
519217 Bos taurus
100134865 Oryctolagus cuniculus
100127490 Sus scrofa
100714324 Cavia porcellus
100860751 Capra hircus
100216433 Ovis aries
101844411 Mesocricetus auratus
100689039 Cricetulus griseus
100154715 Sus scrofa
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