Browse our CDK2 Proteins (CDK2)

Full name:
Cyclin-Dependent Kinase 2 Proteins (CDK2)
On are 34 Cyclin-Dependent Kinase 2 (CDK2) Proteins from 10 different suppliers available. Additionally we are shipping CDK2 Antibodies (465) and CDK2 Kits (41) and many more products for this protein. A total of 580 CDK2 products are currently listed.
A630093N05Rik, cdk2L, CDKN2, CINP, eg1, MGC84068, p33(CDK2), wu:fa10c02, zgc:56598, zgc:77684
list all proteins Gene Name GeneID UniProt
CDK2 362817  
CDK2 1017 P24941
CDK2 12566 P97377

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CDK2 Proteins (CDK2) by Origin

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Top referenced CDK2 Proteins

  1. Human CDK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003156 : Gu, Rosenblatt, Morgan: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. in The EMBO journal 1992 (PubMed)
    Show all 5 references for 2003156

  2. Human CDK2 Protein expressed in Escherichia coli (E. coli) - ABIN667950 : Hannon, Casso, Beach: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 2 references for 667950

  3. Human CDK2 Protein expressed in Wheat germ - ABIN1348936 : Molatore, Marinoni, Lee, Pulz, Ambrosio, degli Uberti, Zatelli, Pellegata: A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. in Human mutation 2010 (PubMed)

More Proteins for CDK2 Interaction Partners

Xenopus laevis Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. evidence that cyclin A1 (show CCNA1 Proteins)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Proteins)/Cdk2 is sufficient to induce apoptosis

Human Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. The authors find that Spy1 (show SPDYA Proteins) confers structural changes to Cdk2 that obviate the requirement of Cdk (show CDK4 Proteins) activation loop phosphorylation.

  2. CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes

  3. Date show that when Wee1 (show WEE1 Proteins) alone is inhibited, Chk1 (show CHEK1 Proteins) suppresses CDC45 (show CDC45 Proteins) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 Proteins)-activity.

  4. Results show that cyclin E1 (show CCNE1 Proteins) and CDK2 participate in STC1 (show STC1 Proteins) promoting cell proliferation of prostate neoplasm cells.

  5. The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (show CDK1 Proteins) inhibition.

  6. periodic phosphorylation of Ku70 (show XRCC6 Proteins) by cyclin-cyclin (show PCNA Proteins) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.

  7. a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 binding, and attenuated E2F-1 (show E2F1 Proteins) sequestration.

  8. These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation

  9. Dsg2 (show DSG2 Proteins) knockdown arrests non-small cell lung cancer cell cycle progression via modulation of p27 (show PAK2 Proteins)-CDK2 levels.

  10. CDK2 protects podocytes from apoptosis and reduced expression of CDK2 associates with the development of diabetic nephropathy.

Mouse (Murine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes

  2. data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals

  3. Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (show CCNE1 Proteins)/cdk2 promoting hepatocarcinogenesis.

  4. This approach allowed us to determine the identity of cyclin E (show CCNE1 Proteins) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (show PCNA Proteins) E1and cyclin E2 (show CCNE2 Proteins))and its associated kinase, Cdk2, in different mouse organs.

  5. RingoA (show SPDYA Proteins) is an important activator of Cdk2 at meiotic telomeres.

  6. Foxo3 (show FOXO3 Proteins) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.

  7. Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.

  8. Sox2 (show SOX2 Proteins) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.

  9. Our data indicate that Cdk2 and Cdk4 (show CDK4 Proteins) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.

  10. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.

Zebrafish Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

  2. PI3-kinase (show PIK3CA Proteins) and Akt (show AKT1 Proteins) participate in insulin (show INS Proteins) stimulation of p34cdc2 (show CDK1 Proteins) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.

  3. an essential role for UHRF1 (show UHRF1 Proteins) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Proteins) during early vertebrate development

Cow (Bovine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

  1. cyclin D1 (show CCND1 Proteins), CDK2 and CDK4 (show CDK4 Proteins) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

CDK2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

Alternative names and synonyms associated with CDK2

  • MGC84068 protein (MGC84068)
  • cyclin-dependent kinase 2 interacting protein (CINP)
  • Cyclin-dependent kinase 2-interacting protein (cinp)
  • cyclin dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (CDK2)
  • cyclin-dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (cdk2)
  • cyclin-dependent kinase 2 (CDK2) (Cdk2)
  • cyclin-dependent kinase-2 alpha (LOC100154715)
  • A630093N05Rik protein
  • cdk2L protein
  • CDKN2 protein
  • CINP protein
  • eg1 protein
  • MGC84068 protein
  • p33(CDK2) protein
  • wu:fa10c02 protein
  • zgc:56598 protein
  • zgc:77684 protein

Protein level used designations for CDK2

MGC84068 protein , Cyclin-dependent kinase 2-interacting protein , cyclin-dependent kinase 2 interacting protein , cyclin-dependent kinase 2-interacting protein , cell division protein kinase 2 , cyclin dependent kinase 2-alpha , cyclin-dependent kinase 2 , cdc2-related protein kinase , cell devision kinase 2 , p33 protein kinase , CDC2 homolog Eg1 protein kinase , Cell division protein kinase 2

444599 Xenopus laevis
744050 Pan troglodytes
100196126 Salmo salar
362817 Rattus norvegicus
1017 Homo sapiens
12566 Mus musculus
406715 Danio rerio
399314 Xenopus laevis
100529062 Gallus gallus
606931 Canis lupus familiaris
519217 Bos taurus
100134865 Oryctolagus cuniculus
100127490 Sus scrofa
100714324 Cavia porcellus
100860751 Capra hircus
100216433 Ovis aries
101844411 Mesocricetus auratus
100689039 Cricetulus griseus
100154715 Sus scrofa
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