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anti-Human Cyclin A Antibodies:
anti-Mouse (Murine) Cyclin A Antibodies:
anti-Rat (Rattus) Cyclin A Antibodies:
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Cow (Bovine) Monoclonal Cyclin A Primary Antibody for ICC, WB - ABIN3043070
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
Show all 5 Pubmed References
Human Polyclonal Cyclin A Primary Antibody for ICC, IF - ABIN441337
Pan, Nakade, Huang, Zhu, Masuzaki, Hasegawa, Murata, Yoshiki, Yamaguchi, Lee, Yang, Tsai, Obata, Yokoyama: Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. in Oncogene 2010
Show all 2 Pubmed References
Human Polyclonal Cyclin A Primary Antibody for ChIP, ICC - ABIN4301457
Mazurek, Luo, Krasnitz, Hicks, Powers, Stillman: DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. in Cancer discovery 2012
Human Polyclonal Cyclin A Primary Antibody for IF (p), IHC (p) - ABIN670281
Zhang, Pan, Xu, Niu, Ma, Xu: Interleukin 18 augments growth ability via NF-?B and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells. in Gene 2015
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (show CCND1 Antibodies) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (show RAD51 Antibodies) interaction with the BRCA2 (show BRCA2 Antibodies) C-terminal domain
inhibition of PDK4 (show PDK4 Antibodies) activity in Hepatocellular carcinoma cells increased cyclin E1 (show CCNE1 Antibodies), cyclin A2, and E2F1 (show E2F1 Antibodies) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (show CDK2 Antibodies) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (show WEE1 Antibodies) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A Antibodies), p27 (show PAK2 Antibodies)-cyclin E (show CCNE1 Antibodies),A/Cdk2 (show CDK2 Antibodies) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (show CCNB1 Antibodies)) expression, positive staining in 90% cases of PTC (show F9 Antibodies) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 Antibodies).
Study describes a positive feedback loop centred on cyclin A2-Cdk2 (show CDK2 Antibodies) inhibition of interphase APC (show APC Antibodies)/C-Cdc20 (show CDC20 Antibodies) to allow further cyclin A2 accumulation and mitotic entry.
PIWIL2 (show PIWIL2 Antibodies) has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (show CDK2 Antibodies) and Cyclin A expression
Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (show AMH Antibodies)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (show MRE11A Antibodies) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (show MRE11A Antibodies) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (show MLXIP Antibodies)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (show EEF2K Antibodies) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (show CTNNB1 Antibodies) and phospholipase C (show PLC Antibodies) pathways.
Ccn2 (show CTGF Antibodies) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT (show ITK Antibodies)).
B-Myb (show MYBL2 Antibodies) represses SMC (show DYM Antibodies) elastin (show ELN Antibodies) gene expression and cyclin A plays a role in the developmental regulation of elastin (show ELN Antibodies) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (show UHRF1 Antibodies) phosphorylation by cyclin-dependent kinase 2 (show CDK2 Antibodies)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)