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Browse our anti-Huntingtin (HTT) Antibodies

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anti-Huntingtin Antibodies (HTT)
On are 131 Huntingtin (HTT) Antibodies from 21 different suppliers available. Additionally we are shipping Huntingtin Kits (16) and Huntingtin Proteins (2) and many more products for this protein. A total of 151 Huntingtin products are currently listed.
AI256365, C430023I11Rik, CG9995, dhtt, Dmel\\CG9995, Hd, Hdh, Hsap\\HD, htt, huntington, IT15, SLC6A4, ZHD
list all antibodies Gene Name GeneID UniProt
HTT 3064 P42858
HTT 15194 P42859
HTT 29424  

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Most Popular Reactivities for anti-Huntingtin (HTT) Antibodies

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anti-Human Huntingtin Antibodies:

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anti-Rat (Rattus) Huntingtin Antibodies:

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Top referenced anti-Huntingtin Antibodies

  1. Human Monoclonal Huntingtin Primary Antibody for WB - ABIN394270 : Aziz, Pijl, Frölich, Snel, Streefland, Roelfsema, Roos: Systemic energy homeostasis in Huntington's disease patients. in Journal of neurology, neurosurgery, and psychiatry 2010 (PubMed)
    Show all 5 references for ABIN394270

  2. Human Monoclonal Huntingtin Primary Antibody for ELISA, WB - ABIN394366 : Godin, Poizat, Hickey, Maschat, Humbert: Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. in The EMBO journal 2010 (PubMed)
    Show all 5 references for ABIN394366

  3. Human Polyclonal Huntingtin Primary Antibody for IHC, ELISA - ABIN1450584 : : A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. in Cell 1993 (PubMed)
    Show all 3 references for ABIN1450584

  4. Human Monoclonal Huntingtin Primary Antibody for IHC (fro), IP - ABIN119306 : Nucifora, Sasaki, Peters, Huang, Cooper, Yamada, Takahashi, Tsuji, Troncoso, Dawson, Dawson, Ross: Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 2 references for ABIN119306

  5. Human Polyclonal Huntingtin Primary Antibody for EIA, WB - ABIN117993 : Lee, Yoshihara, Littleton: Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 2 references for ABIN117993

  6. Human Monoclonal Huntingtin Primary Antibody for IHC (fro), IP - ABIN119305 : Wilkinson, Nguyen, Manilal, Thomas, Neal, Harper, Jones, Morris: Localization of rabbit huntingtin using a new panel of monoclonal antibodies. in Brain research. Molecular brain research 1999 (PubMed)
    Show all 2 references for ABIN119305

  7. Human Monoclonal Huntingtin Primary Antibody for ELISA, WB - ABIN516379 : Thompson, Aiken, Kaltenbach, Agrawal, Illes, Khoshnan, Martinez-Vincente, Arrasate, ORourke, Khashwji, Lukacsovich, Zhu, Lau, Massey, Hayden, Zeitlin, Finkbeiner, Green, LaFerla, Bates, Huang et al.: IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. ... in The Journal of cell biology 2009 (PubMed)

More Antibodies against Huntingtin Interaction Partners

Zebrafish Huntingtin (HTT) interaction partners

  1. These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types.

  2. the effects of Htt deficiency in early zebrafish development.

  3. In vivo, huntingtin deficient zebrafish had a severe phenotype and reduced expression of LXR (show NR1H3 Antibodies) reg'd genes. An LXR (show NR1H3 Antibodies) agonist partially rescued the phenotype and expression of LXR (show NR1H3 Antibodies) target genes in huntingtin deficient zebrafish during early development.

Fruit Fly (Drosophila melanogaster) Huntingtin (HTT) interaction partners

  1. Htt aggregates cause non-cell-autonomous pathology, including loss of vulnerable neurons that can be prevented by inhibiting endocytosis in these neurons.

  2. Glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic machinery.

  3. findings support a role for HTT on dynamin 1 (show DNM1 Antibodies) function and ER homoeostasis. Proteolysis-induced alteration of this function may be relevant to disease.

  4. Htt modulated histone H3K9 methylation levels at the heterochromatin-euchromatin boundary.

  5. In Drosophila, Huntingtin genetically interacts with autophagy pathway components.

  6. Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment

  7. Loss of huntingtin protein results in the disruption of Rab11 vesicle transport.

  8. The specific disruption of Drosophila huntingtin in neuroblast precursors leads to spindle misorientation; Drosophila huntingtin restores spindle misorientation in mammalian cells.

  9. a genomewide RNA interference screen for regulators of mutant Htt aggregation

  10. genes related to nuclear transport, nucleotide processes, and signaling are modifiers of huntingtin aggregation

Human Huntingtin (HTT) interaction partners

  1. HDAC4 (show HDAC4 Antibodies) destabilizes MAP1S (show MAP1S Antibodies), suppresses autophagy flux and promotes the accumulation of mHTT aggregates.

  2. Findings indicate that mutant huntingtin (mHTT) aggregates can be transformed into benign species by isomerase FKBP12 (show FKBP1A Antibodies).

  3. Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 (show MBNL1 Antibodies) and U2AF65 (show U2AF59 Antibodies)

  4. The Htt36Q (mutated) showed higher interaction than Htt17Q (native) with SH3GL3. This increased interaction is believed to form aggregates in the cytoplasm that might be a major trigger to cause Huntington's disorder.

  5. RNAi silencing of both HTT alleles in neural stem cells from hESCs disrupted spindle orientation and mislocalized dynein, the p150Glued (show DCTN1 Antibodies) subunit of dynactin (show DCTN1 Antibodies) and the large NuMA protein (show NUMA1 Antibodies). A 46-glutamine (show GFPT1 Antibodies) expansion was sufficient for a dominant-negative effect.

  6. USP19_b up-regulates the protein levels of the polyglutamine (polyQ)-containing proteins, ataxin-3 (Atx3 (show ATXN3 Antibodies)) and huntingtin (Htt), and thus promotes aggregation of their polyQ-expanded species in cell models

  7. Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes

  8. Alternative HTT splicing eventsin human control and patient post-mortem brains.

  9. As the cholesterol content of the membrane increased, the extent of htt insertion decreased.

  10. Studied the effects of mutant Htt on HSF1 (show HSF1 Antibodies); found under normal conditions, HSF1 (show HSF1 Antibodies) function is highly similar in cells carrying either wild-type or mutant Htt, but polyQ-expanded Htt severely blunts the HSF1 (show HSF1 Antibodies)-mediated stress response.

Mouse (Murine) Huntingtin (HTT) interaction partners

  1. findings point out age- and cell type-dependent vital functions of Htt and the safety of knocking down neuronal Htt expression in adult brains as a treatment.

  2. selective hypothalamic overexpression of mutant HTT directly leads to a reduction of the TH A13 (show UGT1A10 Antibodies) group in the zona incerta with downstream negative effects on BAT (show BAAT Antibodies)

  3. Aberrant phosphorylation of AKT (show AKT1 Antibodies) and MEK (show MDK Antibodies) signalling pathways was identified in cells carrying mutant huntingtin.

  4. Studied the role of the proline-rich region (PRR (show PVRL1 Antibodies)) in Huntingtin function using a knock-in allele of the mouse Huntington's disease gene homolog that expressed full-length normal huntingtin lacking PRR (show PVRL1 Antibodies).

  5. HdhQ111 mice, with trinucleotide repeat expansion-Htt, exhibit tissue specific metabolite profiles that include striatal lipid accumulation.

  6. Study shows endogenous mouse Huntingtin (HTT) protein is reduced in cilia and accumulates in photoreceptor cell bodies, suggesting that HTT loss function contributes to structural and functional defects of photoreceptor cilia in Huntington's disease mouse

  7. We investigated whether the PPARgamma (show PPARG Antibodies) agonist (rosiglitazone) mediates neuroprotection in the mHtt expressing neuroblastoma (show ARHGEF16 Antibodies) cell line (N2A).

  8. Data show that G protein-coupled receptor 52 (Gpr52 (show GPR52 Antibodies)) modulates huntingtin protein (Htt) levels in the striatal cells in vitro and in vivo.

  9. Htt CAG repeat (show CELF3 Antibodies) expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

  10. reduction of SUPT4H (show SUPT4H1 Antibodies) in mouse brains is associated with decreased HTT protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals.

Huntingtin (HTT) Antigen Profile

Antigen Summary

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Alternative names and synonyms associated with Huntingtin (HTT)

  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) antibody
  • huntingtin (LOC100216476) antibody
  • huntingtin (htt) antibody
  • huntingtin (Htt) antibody
  • huntingtin (HTT) antibody
  • huntingtin (HDH) antibody
  • AI256365 antibody
  • C430023I11Rik antibody
  • CG9995 antibody
  • dhtt antibody
  • Dmel\\CG9995 antibody
  • Hd antibody
  • Hdh antibody
  • Hsap\\HD antibody
  • htt antibody
  • huntington antibody
  • IT15 antibody
  • SLC6A4 antibody
  • ZHD antibody

Protein level used designations for anti-Huntingtin (HTT) Antibodies

huntingtin , etID309952.1 , CG9995-PA , CG9995-PB , htt-PA , htt-PB , Huntington's disease protein , huntingtin (Huntington disease) , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , Huntington disease , huntingtin-like , huntington disease protein , HD protein homolog , Huntington disease gene homolog , huntington disease protein homolog

100053721 Equus caballus
100216476 Ovis aries
30214 Danio rerio
43392 Drosophila melanogaster
373520 Strongylocentrotus purpuratus
461084 Pan troglodytes
493287 Xenopus (Silurana) tropicalis
700306 Macaca mulatta
100015315 Monodelphis domestica
100145818 Ciona intestinalis
100219938 Taeniopygia guttata
100329031 Saccoglossus kowalevskii
100403524 Callithrix jacchus
100466808 Ailuropoda melanoleuca
3064 Homo sapiens
15194 Mus musculus
29424 Rattus norvegicus
479074 Canis lupus familiaris
397014 Sus scrofa
615059 Bos taurus
100351801 Oryctolagus cuniculus
422878 Gallus gallus
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