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Browse our anti-Huntingtin (HTT) Antibodies

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anti-Huntingtin Antibodies (HTT)
On are 156 Huntingtin (HTT) Antibodies from 20 different suppliers available. Additionally we are shipping Huntingtin Kits (23) and Huntingtin Proteins (2) and many more products for this protein. A total of 183 Huntingtin products are currently listed.
AI256365, C430023I11Rik, CG9995, dhtt, Dmel\\CG9995, Hd, Hdh, Hsap\\HD, htt, huntington, IT15, SLC6A4, ZHD
list all antibodies Gene Name GeneID UniProt
HTT 3064 P42858
HTT 15194 P42859
HTT 29424  

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Most Popular Reactivities for anti-Huntingtin (HTT) Antibodies

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anti-Human Huntingtin Antibodies:

anti-Mouse (Murine) Huntingtin Antibodies:

anti-Rat (Rattus) Huntingtin Antibodies:

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Top referenced anti-Huntingtin Antibodies

  1. Human Polyclonal Huntingtin Primary Antibody for ELISA, ICC - ABIN4320700 : Hall, Georgel: CHD proteins: a diverse family with strong ties. in Biochemistry and cell biology = Biochimie et biologie cellulaire 2007 (PubMed)
    Show all 3 references for ABIN4320700

  2. Human Polyclonal Huntingtin Primary Antibody for IHC, ELISA - ABIN1450584 : : A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. in Cell 1993 (PubMed)
    Show all 3 references for ABIN1450584

  3. Human Polyclonal Huntingtin Primary Antibody for EIA, WB - ABIN117993 : Lee, Yoshihara, Littleton: Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 2 references for ABIN117993

  4. Human Monoclonal Huntingtin Primary Antibody for IHC (fro), IP - ABIN119305 : Nucifora, Sasaki, Peters, Huang, Cooper, Yamada, Takahashi, Tsuji, Troncoso, Dawson, Dawson, Ross: Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 2 references for ABIN119305

  5. Human Monoclonal Huntingtin Primary Antibody for IHC (fro), IP - ABIN119306 : Wilkinson, Nguyen, Manilal, Thomas, Neal, Harper, Jones, Morris: Localization of rabbit huntingtin using a new panel of monoclonal antibodies. in Brain research. Molecular brain research 1999 (PubMed)
    Show all 2 references for ABIN119306

  6. Human Monoclonal Huntingtin Primary Antibody for ELISA, WB - ABIN516379 : Thompson, Aiken, Kaltenbach, Agrawal, Illes, Khoshnan, Martinez-Vincente, Arrasate, ORourke, Khashwji, Lukacsovich, Zhu, Lau, Massey, Hayden, Zeitlin, Finkbeiner, Green, LaFerla, Bates, Huang et al.: IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. ... in The Journal of cell biology 2009 (PubMed)

More Antibodies against Huntingtin Interaction Partners

Zebrafish Huntingtin (HTT) interaction partners

  1. These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types.

  2. the effects of Htt deficiency in early zebrafish development.

  3. In vivo, huntingtin deficient zebrafish had a severe phenotype and reduced expression of LXR (show NR1H3 Antibodies) reg'd genes. An LXR (show NR1H3 Antibodies) agonist partially rescued the phenotype and expression of LXR (show NR1H3 Antibodies) target genes in huntingtin deficient zebrafish during early development.

Fruit Fly (Drosophila melanogaster) Huntingtin (HTT) interaction partners

  1. Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.

  2. Htt aggregates cause non-cell-autonomous pathology, including loss of vulnerable neurons that can be prevented by inhibiting endocytosis in these neurons.

  3. Glia regulate steady-state numbers of Htt aggregates expressed in neurons through a clearance mechanism that requires the glial scavenger receptor Draper and downstream phagocytic machinery.

  4. findings support a role for HTT on dynamin 1 (show DNM1 Antibodies) function and ER homoeostasis. Proteolysis-induced alteration of this function may be relevant to disease.

  5. Htt modulated histone H3K9 methylation levels at the heterochromatin-euchromatin boundary.

  6. In Drosophila, Huntingtin genetically interacts with autophagy pathway components.

  7. Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment

  8. Loss of huntingtin protein results in the disruption of Rab11 vesicle transport.

  9. The specific disruption of Drosophila huntingtin in neuroblast precursors leads to spindle misorientation; Drosophila huntingtin restores spindle misorientation in mammalian cells.

  10. a genomewide RNA interference screen for regulators of mutant Htt aggregation

Human Huntingtin (HTT) interaction partners

  1. Results suggest that the disruption of untranslated region upstream to the open reading frame (uORF) through CRISPR-Cas9 influences the translation of the mutant Huntingtin gene (mHTT) negatively and, to a lesser extent, disrupts the exon1-intron boundary, which affects the translation of the mHTT.

  2. alleles with a CAG repeat (show CELF3 Antibodies) length of 36-38 occur at high frequency in the general population. The infrequent diagnosis of HD at this CAG length is likely due to low penetrance.

  3. We found that steady state levels of HTT mRNA and protein were not associated with expanded CAG repeat (show CELF3 Antibodies) length. Rather, the products of mutant and normal alleles, both mRNA and protein, were balanced, thereby arguing that a cis (show CISH Antibodies)-regulatory effect of the expanded CAG repeat (show CELF3 Antibodies) is not a critical component of the underlying mechanism of Huntington's disease.

  4. HTT gene intermediate alleles (IAs) show 27 to 35 CAG repeats. The frequency of Intermediate alleles within the chromosomes of the general population ranged from 0.45 to 8.7% and of individuals with family history of Huntington's disease ranged from 0.05 to 5.1%. The higher frequency of Intermediate alleles in the general population (8.7%) was found in one Brazilian cohort.

  5. The +1 trans-frame-encoded product can directly influence the aggregation of the parental Htt exon 1.

  6. analysis of mutation landscape of the Htt-N-terminal region and explore amino acid residue mutations that affect its structural stability and hydrophobic interactions with the polyQ domain

  7. Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.

  8. Data show that huntingtin 25 glutamines (Htt25Q) can form sodium dodecyl sulfate (SDS (show SDS Antibodies))-insoluble polymers and cause cytotoxicity.

  9. Huntingtin is an E2-inducible protein involved in the first steps of E2-induced signaling pathways committed to neuronal protection against oxidative stress.

  10. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Antibodies)) which suggests that MDR1 (show TBC1D9 Antibodies) might be a potential therapeutic target for Huntington's disease.

Mouse (Murine) Huntingtin (HTT) interaction partners

  1. N-terminal acetylation influences the aggregation of htt and its interaction with lipid bilayers

  2. Myelinosomes secreted from testis somatic TM4 (show TPM4 Antibodies) Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (show S100A8 Antibodies) (CF), F508delCFTR.

  3. Hu128/21 mice will be useful for investigations of human HTT that cannot be addressed in Hu97/18 mice, for developing therapies targeted to exon 1, and for preclinical screening of personalized HTT lowering therapies in HD patients of East Asian descent.

  4. We studied the effects of the HttQ111 allele on the C57BL/6J, CD-1 (show KY Antibodies), FVB/NCr1 (show NCR1 Antibodies), and 129S2/SvPasCrl genetic backgrounds, and of two additional alleles, HttQ92 and HttQ50, on the C57BL/6J background. We describe the emergence of a transcriptomic signature in HttQ111/+ mice involving hundreds of differentially expressed genes and changes in diverse molecular pathways

  5. SK2 (show PAPSS2 Antibodies) is nuclear in primary neurons and, unexpectedly, overexpressed SK2 (show PAPSS2 Antibodies) is neurotoxic in a dose-dependent manner.. We also found that SK2 (show PAPSS2 Antibodies) is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease

  6. hese findings imply a possible therapeutic benefit of removing the N-terminal region of HTT containing the polyQ repeat to treat the neurodegeneration in Huntington's disease (HD)

  7. Important caspase (show CASP3 Antibodies) cleavage sites were identified and encoded by exon 12 of the huntingtin protein.

  8. Results suggest a role for p75 (show NGFR Antibodies) in augmenting survival signaling in the striata of Hdh+/Q175 mice, and that the loss of this early pro-survival signaling leads to earlier onset of striatal dysfunction/degeneration

  9. Selective exposure to mutant Htt during development recapitulates characteristic features of the Huntington's disease phenotype.

  10. Htt-deficient round spermatids did not progress beyond step 3.

Huntingtin (HTT) Antigen Profile

Antigen Summary

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Alternative names and synonyms associated with Huntingtin (HTT)

  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) antibody
  • huntingtin (LOC100216476) antibody
  • huntingtin (htt) antibody
  • huntingtin (Htt) antibody
  • huntingtin (HTT) antibody
  • huntingtin (HDH) antibody
  • AI256365 antibody
  • C430023I11Rik antibody
  • CG9995 antibody
  • dhtt antibody
  • Dmel\\CG9995 antibody
  • Hd antibody
  • Hdh antibody
  • Hsap\\HD antibody
  • htt antibody
  • huntington antibody
  • IT15 antibody
  • SLC6A4 antibody
  • ZHD antibody

Protein level used designations for anti-Huntingtin (HTT) Antibodies

huntingtin , etID309952.1 , CG9995-PA , CG9995-PB , htt-PA , htt-PB , Huntington's disease protein , huntingtin (Huntington disease) , solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 , Huntington disease , huntingtin-like , huntington disease protein , HD protein homolog , Huntington disease gene homolog , huntington disease protein homolog

100053721 Equus caballus
100216476 Ovis aries
30214 Danio rerio
43392 Drosophila melanogaster
373520 Strongylocentrotus purpuratus
461084 Pan troglodytes
493287 Xenopus (Silurana) tropicalis
700306 Macaca mulatta
100015315 Monodelphis domestica
100145818 Ciona intestinalis
100219938 Taeniopygia guttata
100329031 Saccoglossus kowalevskii
100403524 Callithrix jacchus
100466808 Ailuropoda melanoleuca
3064 Homo sapiens
15194 Mus musculus
29424 Rattus norvegicus
479074 Canis lupus familiaris
397014 Sus scrofa
615059 Bos taurus
100351801 Oryctolagus cuniculus
422878 Gallus gallus
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