Huntingtin antibody (AA 2703-2911)

Catalog No. ABIN790678

Product Details anti-Huntingtin Antibody

Target: Huntingtin (HTT)

Binding Specificity: AA 2703-2911

Reactivity: Human, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This Huntingtin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Brand: IHC-plus™

Specificity: Reacts with an epitope corresponding to the human HDC region (2703-2911 amino acids) of the huntingtin protein. Detects a 350kD band on Western Blots but also detects smaller degradation products of Huntingtin. Recognizes both denatured and native Huntingtin in human brain.

Purification: Protein G purified

Immunogen: Recombinant protein corresponding to amino acids 2703 - 2911 of huntingtin.

Type of Immunogen: Recombinant protein

Isotype: IgG1

Application Details

Application Notes: Approved: IHC, IHC-Fr, IHC-P (10 μg/mL), IP, WB

Usage: Suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Immunohistochemistry: Frozen, FFPE (human). Increased cytoplasmic staining, relative to nuclear, has been reported using formaldehyde as a fixative compared with acetone/methanol. Positive control: IHC frozen-rabbit btain.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Huntingtin

Target: Huntingtin (HTT)

Alternative Name: HTT / Huntingtin (HTT Products)

Background: Name/Gene ID: HTT
Family: Hungtintin

Synonyms: HTT, Huntingtin, Huntington disease protein, IT15, HD, HD protein

Gene ID: 3064

UniProt: P42858

Pathways: PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport