Browse our MAP3K8 Proteins (MAP3K8)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 8 Proteins (MAP3K8)
On are 9 Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Proteins from 5 different suppliers available. Additionally we are shipping MAP3K8 Antibodies (105) and MAP3K8 Kits (5) and many more products for this protein. A total of 132 MAP3K8 products are currently listed.
c-COT, Cot, Cot/Tpl2, D17TPL2, Est, Estf, MAP3K8, MEKK8, Tpl-2, Tpl2
list all proteins Gene Name GeneID UniProt
MAP3K8 1326 P41279
MAP3K8 26410 Q07174
MAP3K8 116596 Q63562

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MAP3K8 Proteins (MAP3K8) by Origin

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Top referenced MAP3K8 Proteins

  1. Human MAP3K8 Protein expressed in Baculovirus infected Insect Cells - ABIN2003406 : Aparecida Alves, Silva, Villanova, Nicolau, Custódio, Bortoletto, Gonçalves: Differential gene expression profile reveals overexpression of MAP3K8 in invasive endometrioid carcinoma. in European journal of gynaecological oncology 2007 (PubMed)
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More Proteins for MAP3K8 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. role of p105 (show CDH13 Proteins)/Tpl2 signaling in lung homeostasis

  2. rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.

  3. MAP3K8 is a direct target of miR (show MLXIP Proteins)-144-3p, and miR (show MLXIP Proteins)-144-3p downregulation is a factor in renal cell carcinoma (show MOK Proteins) progression through potentiation of MAP3K8 expression.

  4. Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (show IL8 Proteins) secretion and CagA (show S100A8 Proteins)-dependent late IL-8 (show IL8 Proteins) secretion as an alternative signaling molecule in the Erk (show EPHB2 Proteins) pathway.

  5. Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.

  6. the results of the present study demonstrated that the miR (show MLXIP Proteins)-509-3p RCC (show XRCC1 Proteins) suppressor was a significant regulator of the MAP3K8 oncogene (show RAB1A Proteins), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (show MOK Proteins)

  7. findings provide a novel perspective on the role of the IL-33 (show IL33 Proteins)/ST2 (show SULT2A1 Proteins)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment

  8. structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors

  9. TPL2 mediates the phosphorylation of a fraction of nucleophosmin (show NPM1 Proteins) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (show NPM1 Proteins) levels.

  10. MAP3K8 and miR-17-5p expression were inversely correlated with treatment response

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. TPL-2-regulated Ccl24 (show CCL24 Proteins) in CD11c (show ITGAX Proteins)+CD11b (show ITGAM Proteins)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.

  2. role of p105 (show NEDD9 Proteins)/Tpl2 signaling in lung homeostasis

  3. this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice

  4. The kinase TPL2 activates ERK (show EPHB2 Proteins) and p38 (show CRK Proteins) signaling to promote neutrophilic inflammation

  5. TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.

  6. Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.

  7. Map3k8 decreases apoptosis of monocytes and enhances CCR2 (show CCR2 Proteins) expression on Ly6C(high)CD11c (show ITGAX Proteins)(low) monocytes of atherosclerotic ApoE (show APOE Proteins)(-/-) mice fed an high fat diet.

  8. results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (show FOXP3 Proteins) expression and Treg immunosuppressive functions.

  9. Tpl2 plays a significant role in promoting HCC (show FAM126A Proteins) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (show FAM126A Proteins) prevention.

  10. Tpl2 null mice displayed low COX-2 mRNA induction in adipose tissue.

MAP3K8 Protein Profile

Protein Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with MAP3K8

  • mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
  • mitogen-activated protein kinase kinase kinase 8 (map3k8)
  • mitogen-activated protein kinase kinase kinase 8 (Map3k8)
  • c-COT protein
  • Cot protein
  • Cot/Tpl2 protein
  • D17TPL2 protein
  • Est protein
  • Estf protein
  • MAP3K8 protein
  • MEKK8 protein
  • Tpl-2 protein
  • Tpl2 protein

Protein level used designations for MAP3K8

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)

450384 Pan troglodytes
100018684 Monodelphis domestica
100063602 Equus caballus
100355566 Oryctolagus cuniculus
100385107 Callithrix jacchus
100480593 Ailuropoda melanoleuca
100541097 Meleagris gallopavo
100562883 Anolis carolinensis
100579516 Nomascus leucogenys
420479 Gallus gallus
1326 Homo sapiens
487085 Canis lupus familiaris
535622 Bos taurus
26410 Mus musculus
116596 Rattus norvegicus
449002 Sus scrofa
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