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Browse our MAP3K8 Proteins (MAP3K8)

Full name:
Mitogen-Activated Protein Kinase Kinase Kinase 8 Proteins (MAP3K8)
On are 7 Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) Proteins from 5 different suppliers available. Additionally we are shipping MAP3K8 Antibodies (97) and MAP3K8 Kits (5) and many more products for this protein. A total of 121 MAP3K8 products are currently listed.
c-COT, Cot, Cot/Tpl2, D17TPL2, Est, Estf, MAP3K8, MEKK8, Tpl-2, Tpl2
list all proteins Gene Name GeneID UniProt
MAP3K8 1326 P41279
MAP3K8 26410 Q07174
MAP3K8 116596 Q63562

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MAP3K8 Proteins (MAP3K8) by Origin

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Top referenced MAP3K8 Proteins

  1. Human MAP3K8 Primary Antibody for - ABIN2003406 : Aparecida Alves, Silva, Villanova, Nicolau, Custódio, Bortoletto, Gonçalves: Differential gene expression profile reveals overexpression of MAP3K8 in invasive endometrioid carcinoma. in European journal of gynaecological oncology 2007 (PubMed)
    Show all 2 references for ABIN2003406

More Proteins for MAP3K8 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (show IL8 Proteins) secretion and CagA (show S100A8 Proteins)-dependent late IL-8 (show IL8 Proteins) secretion as an alternative signaling molecule in the Erk (show EPHB2 Proteins) pathway.

  2. Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.

  3. the results of the present study demonstrated that the miR (show MLXIP Proteins)-509-3p RCC (show XRCC1 Proteins) suppressor was a significant regulator of the MAP3K8 oncogene (show RAB1A Proteins), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (show MOK Proteins)

  4. findings provide a novel perspective on the role of the IL-33 (show IL33 Proteins)/ST2 (show SULT2A1 Proteins)/COT signaling pathway in supporting cancer-associated inflammation in the tumor microenvironment

  5. structurally versatile active site significantly impacts the design of potent, low molecular weight COT kinase inhibitors

  6. TPL2 mediates the phosphorylation of a fraction of nucleophosmin (show NPM1 Proteins) at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state nucleophosmin (show NPM1 Proteins) levels.

  7. MAP3K8 and miR-17-5p expression were inversely correlated with treatment response

  8. COT interacts with and phosphorylates Pin1 (show PIN1 Proteins) on Ser16. Consequently, Pin1 (show PIN1 Proteins) Ser16 phosphorylation by COT increases cyclin D1 (show CCND1 Proteins) abundance and enhances tumorigenecity of MCF7 cells.

  9. Aberrant expression of A-, B-, and C-RAF (show RAF1 Proteins), and COT is frequent in PTC (show F9 Proteins); increased expression of COT is correlated with recurrence of PTC (show F9 Proteins).

  10. Tpl2 overexpression and downregulation showed significant stimulatory and inhibitory effects on tumorigenic and metastatic potential of ADI PC cells.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) interaction partners

  1. results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (show FOXP3 Proteins) expression and Treg immunosuppressive functions.

  2. Tpl2 plays a significant role in promoting HCC (show FAM126A Proteins) development by its pro-inflammatory effect, which suggested that Tpl2 could be a molecular target for HCC (show FAM126A Proteins) prevention.

  3. Tpl2 null mice displayed low COX-2 mRNA induction in adipose tissue.

  4. The stimulating effect of estradiol on progesterone synthesis relies on the estrogen no-classical protein-coupled receptor 30, and MAP3K8.

  5. these findings establish an essential role for Tpl2 in antiviral host defense mechanisms.

  6. Tpl2 promotes Th1 (show HAND1 Proteins), but not Th17, differentiation in a T cell transfer model of colitis.

  7. Tpl2 is an essential regulator of reactive oxygen species production during TLR3 (show TLR3 Proteins)/9 signaling.

  8. Following epithelial injury, intestinal myofibroblasts sense innate or inflammatory signals and activate, via Tpl2, the cyclooxygenase-2 (Cox-2 (show PTGS2 Proteins))-prostaglandin E2 (PGE2) pathway, which are essential for the epithelial homeostatic response.

  9. Tpl2 regulates various inflammatory pathways by activating the ERK (show EPHB2 Proteins) mediated MAP kinase (show MAPK1 Proteins) pathway in innate immune cells such as macrophages and dendritic cells in humans but not in mice.

  10. This study demonstrates a Tpl2-dependent mechanism for macrophage expression of select chemokine (show CCL1 Proteins) receptors.

MAP3K8 Protein Profile

Protein Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with MAP3K8

  • mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
  • mitogen-activated protein kinase kinase kinase 8 (map3k8)
  • mitogen-activated protein kinase kinase kinase 8 (Map3k8)
  • c-COT protein
  • Cot protein
  • Cot/Tpl2 protein
  • D17TPL2 protein
  • Est protein
  • Estf protein
  • MAP3K8 protein
  • MEKK8 protein
  • Tpl-2 protein
  • Tpl2 protein

Protein level used designations for MAP3K8

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)

450384 Pan troglodytes
100018684 Monodelphis domestica
100063602 Equus caballus
100355566 Oryctolagus cuniculus
100385107 Callithrix jacchus
100480593 Ailuropoda melanoleuca
100541097 Meleagris gallopavo
100562883 Anolis carolinensis
100579516 Nomascus leucogenys
420479 Gallus gallus
1326 Homo sapiens
487085 Canis lupus familiaris
535622 Bos taurus
26410 Mus musculus
116596 Rattus norvegicus
449002 Sus scrofa
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