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Browse our MTOR Proteins (FRAP1)

Full name:
Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteins (FRAP1)
On are 3 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteins from 3 different suppliers available. Additionally we are shipping MTOR Antibodies (344) and MTOR Kits (39) and many more products for this protein. A total of 400 MTOR products are currently listed.
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
list all proteins Gene Name GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

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MTOR Proteins (FRAP1) by Origin

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Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. our findings provide for the first time that PF-04691502 inhibits the constitutively activated PI3K/mTOR pathway in aggressive B-cell NHL cell lines associated with inhibition of cell cycle progression, cell proliferation and promotion of apoptosis.

  2. Data suggest that combination of proto-oncogene (show RAB1A Proteins) protein B (show LEPREL2 Proteins)-raf (BRAF (show BRAF Proteins)) and mTOR serine-threonine kinase (show TLK2 Proteins) (mTOR) inhibition forms the basis of a treatment regimen of thyroid cancer.

  3. the combination of an mTOR inhibitor and an autophagy inhibitor may be effective in the treatment of osteosarcoma because it effectively induces the apoptotic pathway.

  4. Data suggest that nitroxoline induces anticancer activity through AMP (show APRT Proteins)-activated kinase (AMPK (show PRKAA1 Proteins))/mTOR serine-threonine kinase (show TLK2 Proteins) (mTOR) signaling pathway via checkpoint kinase 2 (Chk2 (show CHEK2 Proteins)) activation.

  5. Collybistin (show Arhgef9 Proteins) forms a complex with mTOR and eIF3 (show EIF3A Proteins) and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism.

  6. Akt (show AKT1 Proteins)/mTOR signaling was hyperactive in low miR (show MLXIP Proteins)-149 expressing gliomas.

  7. 4E-BP1 (show EIF4EBP1 Proteins) and p53 (show TP53 Proteins) gene expressions were increased, but p-4E-BP1 (show EIF4EBP1 Proteins) and p-mTOR protein expressions were decreased in nsclc.

  8. Study provides further evidence for the role of mTOR hyperactivation and reduced autophagy in the accumulation of protein oxidative damage during Down's Syndrome

  9. Data show that puquitinib mesylate (XC-302) induced autophagy in nasopharyngeal cancer cells CNE-2 by promoting cell autophagy and inhibits the phosphatidylinositol 3-Kinase (PI3K (show PIK3CA Proteins))/AKT (show AKT1 Proteins) protein/TOR (show RORC Proteins) serine-threonine kinases (mTOR) signaling pathway.

  10. Data show that mTOR serine-threonine kinase (show TLK2 Proteins) (mTOR) inhibitor AZD2014 has broad antiproliferative effects across multiple cell lines.

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. analysis of mTORC2 components mTOR, Rictor and mSin1 reveals diurnal variation in mouse perivascular adipose tissue

  2. Study provides further evidence for the role of mTOR hyperactivation and reduced autophagy in the accumulation of protein oxidative damage during Down's Syndrome

  3. Chronic treatment with fluoxetine can induce synaptic protein expression by activating the mTOR signaling pathway.

  4. Hyperactive mTOR signaling combined with loss of p53 (show TP53 Proteins) in mice induces tumors similar to human acinar cell carcinoma.

  5. miR (show MLXIP Proteins)-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1 (show FOXO1 Proteins)-modulated positive feedback loop with mTOR-p-PI3K/AKT (show AKT1 Proteins)-c-JUN (show JUN Proteins).

  6. sustained activation of mTORC1 signaling in skeletal muscle regulated whole-body metabolism through the induction of FGF21 (show FGF21 Proteins), which, over the long term, caused severe lipodystrophy

  7. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  8. Our study suggests that Ab25-35 induces autophagy and the PI3K/AKT (show AKT1 Proteins)/mTOR/p70S6K (show RPS6KB1 Proteins) pathway is involved in the process, which improves our understanding of the pathogenesis of Alzheimer's disease and provides an additional model for AD research

  9. mTOR signaling pathway did not play a major role in lung injury and autophagy of lung tissue cells induced by lipopolysaccharide

  10. mTOR inhibitor, sirolimus, suppresses the tumor's growth, suggesting that mTOR inhibitors might be effective in control of FLCN (show FLCN Proteins)-deficient RCC (show XRCC1 Proteins).

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.

  2. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  3. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).

  4. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  5. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.

  2. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).

  3. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  4. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.

  5. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.

  6. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

  7. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  8. Findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb (show RHEB Proteins) and mTORC1 and promotion of a differentiated vascular smooth muscle cell phenotype.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. 14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  2. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.

  3. Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  4. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.

  5. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates

  6. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  7. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner

  8. mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik protein
  • AI327068 protein
  • flat protein
  • FRAP protein
  • frap1 protein
  • FRAP2 protein
  • RAFT1 protein
  • RAPT1 protein
  • tor protein
  • wu:fc22h08 protein

Protein level used designations for FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
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