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Browse our MTOR Proteins (FRAP1)

Full name:
Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteins (FRAP1)
On are 4 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteins from 4 different suppliers available. Additionally we are shipping MTOR Antibodies (347) and MTOR Kits (38) and many more products for this protein. A total of 403 MTOR products are currently listed.
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
list all proteins Gene Name GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

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MTOR Proteins (FRAP1) by Origin

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Top referenced MTOR Proteins

  1. Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555 : Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016 (PubMed)

More Proteins for MTOR Interaction Partners

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. 4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR/p70S6K (show RPS6KB1 Proteins) signaling pathway.

  2. mTORC2 (show CRTC2 Proteins) is crucial for Notch (show NOTCH1 Proteins) signaling to regulate Akt (show AKT1 Proteins) and NF-kappaB (show NFKB1 Proteins).

  3. The PLD1/PA-mTORC2 (show CRTC2 Proteins) signal pathway is overactivated in endometrial carcinomas.

  4. results suggest that mTOR could be a primary resistance factor of resminostat. Targeted inhibition of mTOR may thus significantly sensitize HCC (show FAM126A Proteins) cells to resminostat

  5. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Proteins) activates mTORC2 (show CRTC2 Proteins) remains poorly defined.

  6. multiple-site acetylation of Rictor signals for increased activation of mTORC2 (show CRTC2 Proteins), providing a critical link between nutrient-sensitive deacetylases and mTORC2 (show CRTC2 Proteins) signaling to Akt (show AKT1 Proteins)

  7. Rictor phosphorylation takes place in mammalian target of rapamycin (mTORC)2-deficient cells; this modification may play a role in regulating not only mTORC2 but also the mTORC2-independent function of rictor.

  8. mTORC2 (show CRTC2 Proteins) signaling promotes GBM growth and survival and activates NF-kappaB (show NFKB1 Proteins).

  9. Data show that mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2 (show CRTC2 Proteins)) are up-regulated in neoplastic and developing immature mast cells compared with their terminally differentiated counterparts.

  10. In neuroblastoma (show ARHGEF16 Proteins), transcription of HIF2A (show EPAS1 Proteins) is strongly dependent on mTORC2 (show CRTC2 Proteins).

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. our results demonstrate that mTOR is critically required for cardiomyocyte growth, viability and oxygen supply in early postnatal myocardium and provide insight into the molecular mechanisms involved in apoptosis of mTOR-depleted cardiomyocytes.

  2. mTORC2 (show CRTC2 Proteins) is crucial for Notch (show NOTCH1 Proteins) signaling to regulate Akt (show AKT1 Proteins) and NF-kappaB (show NFKB1 Proteins).

  3. findings provide the first linkage of host signals to parasite-mediated host cell reorganization and demonstrate migratory suppression as a novel functional consequence of this process that is associated with mTORC2 (show CRTC2 Proteins)-mediated centrosome constraint

  4. mTORC1 is a novel downstream pathway of Ang II (show AGT Proteins) type 1 receptor signaling in the brain and selectively mediates the effect of Ang II (show AGT Proteins) on drinking behavior.

  5. Sin1 (show MAPKAP1 Proteins)-mTORC2 (show CRTC2 Proteins) suppresses rag1,2 and il7r (show IL7R Proteins) gene expression through Akt2 (show AKT2 Proteins) in B cells.

  6. Rictor phosphorylation takes place in mammalian target of rapamycin (mTORC)2-deficient cells; this modification may play a role in regulating not only mTORC2 but also the mTORC2-independent function of rictor.

  7. Deletion of Rac1 in primary cells using an inducible-Cre/Lox (show LOX Proteins) approach inhibits basal and growth-factor activation of both mTORC1 and mTORC2 (show CRTC2 Proteins).

  8. Mammalian target of rapamycin complex 2 regulates inflammatory response to stress

  9. Loss of mTORC2 (show CRTC2 Proteins) signaling in the cortex independent of mTORC1 can disrupt normal brain development and function and may contribute to some of the neurologic manifestations seen in TSC (show SLC12A3 Proteins)

  10. The phosphorylation of SIN1 (show MAPKAP1 Proteins) by Akt (show AKT1 Proteins) was found to regulate mTORC2 (show CRTC2 Proteins) activity in response to growth factors, revealing topological insights into the Akt (show AKT1 Proteins)/mTOR signaling network.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.

  2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.

  3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).

  5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

  2. AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.

  4. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).

  5. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  6. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.

  7. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.

  8. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

  9. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  10. Findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb (show RHEB Proteins) and mTORC1 and promotion of a differentiated vascular smooth muscle cell phenotype.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

  2. 14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.

  4. Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  5. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.

  6. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates

  7. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner

  9. mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik protein
  • AI327068 protein
  • flat protein
  • FRAP protein
  • frap1 protein
  • FRAP2 protein
  • RAFT1 protein
  • RAPT1 protein
  • tor protein
  • wu:fc22h08 protein

Protein level used designations for FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
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