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Browse our MTOR Proteins (FRAP1)

Full name:
Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteins (FRAP1)
On www.antibodies-online.com are 4 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteins from 4 different suppliers available. Additionally we are shipping MTOR Antibodies (350) and MTOR Kits (35) and many more products for this protein. A total of 403 MTOR products are currently listed.
Synonyms:
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
list all proteins Gene Name GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

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MTOR Proteins (FRAP1) by Origin

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Top referenced MTOR Proteins

  1. Human MTOR Protein expressed in Human - ABIN2726555 : Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016 (PubMed)

More Proteins for MTOR Interaction Partners

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. A slight overexpression of PIK3CA (show PIK3CA Proteins), PIK3CB, AKT1 (show AKT1 Proteins), MTOR, RPS6KB1 (show RPS6KB1 Proteins), EIF4EBP1 (show EIF4EBP1 Proteins) and EIF4E (show EIF4E Proteins) genes.

  2. The biological association between mTOR activation and AR pathway suggests that there may exist a subgroup of TNBC.

  3. The proteins of the pathways p-Akt (show AKT1 Proteins), p-mTOR, p-p70S6K (show RPS6KB1 Proteins) and p-4E-BP1 (show EIF4EBP1 Proteins) were downregulated.

  4. Tan-IIA was able to decrease the protein expression levels of EGFR (show EGFR Proteins), IGFR, PI3K (show PIK3CA Proteins), AKT (show AKT1 Proteins) and mTOR.

  5. Phosphorylation level of Akt (show AKT1 Proteins) declined from 138.45+/-13.8 to 69.9+/-29.7% in SGC (show SGCB Proteins)-7901, and from 115.5+/-26.6 to 49.07+/-27% in MGC-803 and phosphorylation level of mTOR also significantly decreased.While apoptosis of gastric cancer(GA) cells increased which we verified with apoptosis proteins and staining analysis. Our data showed that RLIP76 (show RALBP1 Proteins) plays a significant oncogenic role in GC and it maybe a potential target in GC

  6. Our results demonstrated that NC inhibits development of glioblastoma multiforme (GBM) by targeting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR signaling pathway and provides a potential therapeutic agent for the treatment of GBM.

  7. The PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins)-mTOR pathway coordinates the uptake and utilization of multiple nutrients.

  8. Temsirolimus could act as an mTOR inhibitor to induce autophagy in adenoid cystic carcinoma both in vitro and in vivo.

  9. Brefeldin A appears to attenuate TNF-alpha (show TNF Proteins)-stimulated inflammatory mediator production in keratinocytes by suppressing the activation of the Akt (show AKT1 Proteins), mTOR, and NF-kappaB (show NFKB1 Proteins) pathways.

  10. RCE-4 isolated from Reineckia carnea exerted beneficially anti-cervical cancer effect on HeLa cells, mainly inhibiting PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR signaling pathway phosphorylation and NF-kappaB (show NFKB1 Proteins) activation, promoting HeLa cell apoptosis.

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. Suggest the involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms.

  2. Data suggest that a combined inhibition of mechanistic target of rapamycin protein (mTOR) and beta-catenin (show CTNNB1 Proteins) signaling transduction may be a therapeutic strategy for patients with chronic kidney.

  3. Temsirolimus could act as an mTOR inhibitor to induce autophagy in adenoid cystic carcinoma both in vitro and in vivo.

  4. The present study indicates that regulation of DEPTOR (show DEPTOR Proteins)/mTOR signaling may be an important mechanism for glutamine (show GFPT1 Proteins) in prevention against the development of colitis-associated colorectal cancer (CAC (show SLC25A20 Proteins)): the chemopreventive effect of dietary glutamine (show GFPT1 Proteins) on CAC (show SLC25A20 Proteins) is, at least in part, associated with the induction of autophagy.

  5. Shengmai injection provides remarkable protection against cerebral ischemia/reperfusion injury, which may be partly due to the inhibition of autophagy via AMPK (show PRKAA1 Proteins)/mTOR/JNK (show MAPK8 Proteins) pathways.

  6. These results suggested that inhibition of mTOR had a neuroprotective effect on serumdeprived 661W cells. In conclusion, the mTOR pathway is a critical molecular signal for cell cycle regulation and energy metabolism, and inhibiting the mTOR pathway may attenuate neurotrophin (show BDNF Proteins) withdrawalinduced damage.

  7. The down-regulation of p27 (show CDKN1B Proteins) and the activation of mTOR pathway may be involved in miR (show MLXIP Proteins)-222-induced heart failure and autophagy inhibition.

  8. The results suggest that KCa3.1 (show KCNN4 Proteins) activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt (show AKT1 Proteins)/mTOR signaling pathways.

  9. Uhrf1 (show UHRF1 Proteins) regulation of the Akt (show AKT1 Proteins)-mTOR signaling pathway is required for invariant natural killer T cell development.

  10. The predominant AKT (show AKT1 Proteins) isoform in the central nervous system, AKT3 (show AKT3 Proteins), induces much more robust axon regeneration than AKT1 (show AKT1 Proteins) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Proteins)-induced axon regeneration.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.

  2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.

  3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).

  5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

  2. AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.

  4. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).

  5. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  6. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.

  7. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.

  8. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

  9. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  10. Findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb (show RHEB Proteins) and mTORC1 and promotion of a differentiated vascular smooth muscle cell phenotype.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. 14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  2. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.

  3. Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  4. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.

  5. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates

  6. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  7. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner

  8. mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik protein
  • AI327068 protein
  • flat protein
  • FRAP protein
  • frap1 protein
  • FRAP2 protein
  • RAFT1 protein
  • RAPT1 protein
  • tor protein
  • wu:fc22h08 protein

Protein level used designations for FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

GENE ID SPECIES
100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
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