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Browse our MTOR Proteins (FRAP1)

Full name:
Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteins (FRAP1)
On www.antibodies-online.com are 3 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteins from 3 different suppliers available. Additionally we are shipping MTOR Antibodies (344) and MTOR Kits (33) and many more products for this protein. A total of 394 MTOR products are currently listed.
Synonyms:
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
list all proteins Gene Name GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

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MTOR Proteins (FRAP1) by Origin

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Top referenced MTOR Proteins

  1. Human MTOR Protein expressed in Human - ABIN2726555 : Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016 (PubMed)

More Proteins for MTOR Interaction Partners

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. ROS (show ROS1 Proteins)-mediated autophagy depends on the inhibition of the Akt (show AKT1 Proteins)/mTOR pathway.

  2. AMPK/mTOR pathway may involve in CSC-3436 switched tamoxifen-induced autophagy to apoptosis.

  3. PiR (show PIR Proteins)-55490 was found to bind 3'UTR of mTOR messenger RNA.

  4. Increased expression of mTOR was found in placenta from women with gestational diabetes.

  5. Results indicate that eIF4B (show EIF4B Proteins) integrates the signals from Pim (show PIM1 Proteins) and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR pathways in Abl (show ABL1 Proteins)-expressing leukemic cells.

  6. This study demonstrated the interaction of mTOR signalling pathway and testicular seminoma by showing intense cytoplasmic mTOR pathway proteins immunoreactivity in the seminoma, for the first time in humans.

  7. The results suggest that KCa3.1 (show KCNN4 Proteins) activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR signaling pathways.

  8. miR (show MLXIP Proteins)-496 is involved in the regulation of human aging through the control of mTOR.

  9. by targeting mTOR signal pathway, miR (show MLXIP Proteins)-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR (show MLXIP Proteins)-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively.

  10. combination therapy in mRCC has not provided clinical benefit. Several trials over the past decade have explored combinations, largely of VEGF (show VEGFA Proteins) inhibitors plus VEGF (show VEGFA Proteins) inhibitors or VEGF (show VEGFA Proteins) inhibitors plus mTOR inhibitors

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. The down-regulation of p27 (show CDKN1B Proteins) and the activation of mTOR pathway may be involved in miR (show MLXIP Proteins)-222-induced heart failure and autophagy inhibition.

  2. The results suggest that KCa3.1 (show KCNN4 Proteins) activation contributes to dysfunctional tubular autophagy in diabetic nephropathy through PI3K/Akt (show AKT1 Proteins)/mTOR signaling pathways.

  3. Uhrf1 (show UHRF1 Proteins) regulation of the Akt (show AKT1 Proteins)-mTOR signaling pathway is required for invariant natural killer T cell development.

  4. The predominant AKT (show AKT1 Proteins) isoform in the central nervous system, AKT3 (show AKT3 Proteins), induces much more robust axon regeneration than AKT1 (show AKT1 Proteins) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Proteins)-induced axon regeneration.

  5. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (show HDAC1 Proteins) and HdAC2 (show HDAC2 Proteins), tuberous sclerosis complex 2 (TSC2), and mTOR srine-threonine kinases (mTOR).

  6. This work provides tantalizing evidence that mTOR plays a role in controlling lysosome morphology and trafficking by modulating microtubule-based motor activity in leukocytes

  7. brain somatic activating mutations in MTOR cause Focal cortical dysplasia type II.

  8. Gene expression profiling reveals transcriptional regulation by Fbxw7 (show FBXW7 Proteins)/mTOR pathway in radiation-induced mouse thymic lymphomas.

  9. constitutive TGF-beta (show TGFB1 Proteins) signaling or depletion of mTOR arrested NK cell development, whereas deletion of the TGF-beta (show TGFB1 Proteins) receptor subunit TGF-betaRII enhanced mTOR activity and the cytotoxic activity of the NK cells in response to IL-15 (show IL15 Proteins).

  10. In osteoclasts, the lysosome plays a key role not only in mTOR activation but also in its deactivation through protein degradation.

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.

  2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.

  3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).

  5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  2. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.

  3. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).

  4. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  5. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.

  6. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.

  7. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

  8. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  9. Findings illustrate a mechanism for the cardioprotective effects of lovastatin through inhibition of Rheb (show RHEB Proteins) and mTORC1 and promotion of a differentiated vascular smooth muscle cell phenotype.

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. 14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  2. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.

  3. Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  4. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.

  5. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates

  6. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  7. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner

  8. mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik protein
  • AI327068 protein
  • flat protein
  • FRAP protein
  • frap1 protein
  • FRAP2 protein
  • RAFT1 protein
  • RAPT1 protein
  • tor protein
  • wu:fc22h08 protein

Protein level used designations for FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

GENE ID SPECIES
100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
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