Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
Hydrogen sulfide (show SQRDL Proteins) influences multiple biological functions of HCC (show FAM126A Proteins) cells through inhibiting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR signaling pathway.
Results show that expression level of mTOR and BCL2 (show BCL2 Proteins) are regulated by miR497 and provide evidence for their role in the development of TMZ-resistance phenotype of glioma cells.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Proteins) activates mTORC2 (show CRTC2 Proteins) remains poorly defined.
activation of MTOR in the epithelium promotes LPS (show IRF6 Proteins)-induced acute lung injury.
Authors identified active mTOR as a novel inducer of NED, and elucidated a mechanism underlying the malignant transformation of NEPCa by recapitulating NED in vitro.
PKN (show PKN1 Proteins) kinase activity was measured by incorporation of (32) P into protein substrates. Phosphorylation of the turn-motif (TM) in PKN (show PKN1 Proteins) proteins by mTOR was analyzed using the TORC2 (show CRTC2 Proteins)-specific inhibitor torin (show PRDX2 Proteins) and a PKN1 (show PKN1 Proteins) phospho-TM-specific antibody.
Data suggest that high expression of phosphorylated mTOR (p-mTORS2448) and YAP1 (show YAP1 Proteins) correlates with poor prognosis of glioma patients; potential interaction between mTOR and YAP1 (show YAP1 Proteins) signaling pathways may participate in development/progression of gliomas. (mTOR = rapamycin and FKBP12 target 1 protein; YAP1 (show YAP1 Proteins) = Yes-associated protein 1 (show YAP1 Proteins))
IL-1beta (show IL1B Proteins) induced apoptosis and the expression of catabolic mediators by inducing autophagy, and the autophagy in part was mediated through the activation of AKT (show AKT1 Proteins)/mTOR/P70S6K (show RPS6KB1 Proteins) signaling pathway in human osteoarthritis chondrocytes.
High mTOR expression is associated with Lung cancer.
Inhibits CD25 (show IL2RA Proteins) translation through regulation of the LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins)-mTOR pathway to suppress T cells.
MDSCs ameliorated AKI and the protective effect was enhanced by mTOR signal inhibition.
The involvement of mTOR-PGC-1alpha pathway in the connection between FTO (show FTO Proteins) and muscle differentiation is displayed.
Taken together, the above results clearly demonstrated an mTORC2 (show CRTC2 Proteins)-dependent regulation of actin polymerization that contributed to the effects of ERalpha (show ESR1 Proteins) and ERbeta (show ESR2 Proteins) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
activation of MTOR in the epithelium promotes LPS (show TLR4 Proteins)-induced acute lung injury.
results demonstrated that Rictor/mTORC2 (show CRTC2 Proteins) might play an important role in the cardiomyocyte differentiation of mES (show PTCH1 Proteins) cells.
Chemerin (show RARRES2 Proteins)-CMKLR1 (show CMKLR1 Proteins) activates Akt (show AKT1 Proteins)/mTOR and ERK (show EPHB2 Proteins) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (show MEOX2 Proteins) weakens the effect of chemerin (show RARRES2 Proteins) on preadipocyte biofunctions.
exploration of the role of AMPK (show PRKAA1 Proteins) in lipopolysaccharide (LPS (show TLR4 Proteins))-induced myocardial dysfunction and elucidated the potential mechanisms of AMPK (show PRKAA1 Proteins)/mTOR pathway regulating autophagy in young and aged mice
ENPP2 (show ENPP2 Proteins) links Activin-A (show INHBA Proteins) enhanced mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Together, these results indicate that Mtor expression in Sertoli cells is required for the maintenance of spermatogenesis and the progression of germ cell development through the pachytene spermatocyte stage. One mechanism of mTOR action may be to regulate gap junction dynamics by inhibiting AKT (show AKT1 Proteins), thereby decreasing GJA1 (show GJA1 Proteins) phosphorylation and internalization.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.
By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 (show IGF1 Proteins) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.
Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner
mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin