You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our MTOR Proteins (FRAP1)

Full name:
Mechanistic Target of Rapamycin (serine/threonine Kinase) Proteins (FRAP1)
On www.antibodies-online.com are 4 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) Proteins from 4 different suppliers available. Additionally we are shipping MTOR Antibodies (348) and MTOR Kits (41) and many more products for this protein. A total of 408 MTOR products are currently listed.
Synonyms:
2610315D21Rik, AI327068, flat, FRAP, frap1, FRAP2, RAFT1, RAPT1, tor, wu:fc22h08
list all proteins Gene Name GeneID UniProt
FRAP1 2475 P42345
FRAP1 56717 Q9JLN9
FRAP1 56718 P42346

Show all synonyms

MTOR Proteins (FRAP1) by Origin

Select your origin of interest

Top referenced MTOR Proteins

  1. Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555 : Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016 (PubMed)

More Proteins for MTOR Interaction Partners

Horse (Equine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

Human Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Proteins) activates mTORC2 (show CRTC2 Proteins) remains poorly defined.

  2. results suggested that mTOR-siRNA could effectively inhibit the proliferation, migration and EMT (show ITK Proteins) of HLE (show ELANE Proteins) B3 cells through the inhibition of p70S6K (show RPS6KB1 Proteins) and AKT (show AKT1 Proteins).

  3. Polyphenolic compounds have been shown to delay the ageing process by targeting mTOR and related pathways

  4. We revealed that activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway was the main cause of impaired autophagy in ELK3 (show ELK3 Proteins) KD. Our results suggest that targeting ELK3 (show ELK3 Proteins) may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics.

  5. SPOP (show SPOP Proteins) mutation activates both PI3K (show PIK3CA Proteins)/mTOR and androgen receptor (show AR Proteins) signaling, effectively uncoupling the normal negative feedback between these two pathways.

  6. 4EBP1 (show EIF4EBP1 Proteins)/c-MYC (show MYC Proteins)/PUMA (show BBC3 Proteins) and NF-kappaB (show NFKB1 Proteins)/EGR1 (show EGR1 Proteins)/BIM (show BCL2L11 Proteins) pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.

  7. It has been demonstrated that branched-chain amino acid (BCAA) catabolism is activated in human breast cancer, and abolishment of BCAA catabolism by knocking down BCAT1 (show BCAT1 Proteins) inhibits breast cancer cell growth by repressing mTOR-mediated mitochondrial biogenesis and function.

  8. This study demonstrates that one of the critical mechanisms underlying curcumin inhibiting heat-induced apoptosis is through suppressing NADPH Oxidase 2 (show CYBB Proteins) and activating the Akt (show AKT1 Proteins)/mTOR signaling pathway in bronchial epithelial cells.

  9. Likewise, inhibiting the PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)-mTOR pathway with the ATP-competitive mTOR inhibitor PP242 reduced CD44 (show CD44 Proteins) protein in SNU-423 and SNU-449 cells without altering CD44 (show CD44 Proteins) mRNA levels.

  10. Compelling evidence suggests that mTOR is an arising regulator of male fertility and better understanding of this atypical protein kinase coordinated action in testis will provide insightful information concerning its biological significance in other tissues/organs.

Mouse (Murine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. mTOR regulates IL-23 (show IL23A Proteins)-driven IL-17 (show IL17A Proteins) and IL-22 (show IL22 Proteins) production in neutrophils

  2. selective mTORC1 activation in smooth muscle cells induced by deleting the negative mTORC1 regulator tuberous sclerosis complex 1 gene (TSC1 (show TSC1 Proteins)) was sufficient to produce pulmonary hypertension.

  3. We apply ligation-free ribosome profiling to mouse brain tissue to identify new patterns of cell type-specific translation and test its ability to identify translational targets of mTOR signaling in the brain.

  4. Data show that Akt (show AKT1 Proteins)/mTOR and MAPK (show MAPK1 Proteins) pathways were activated in ovine pulmonary adenocarcinoma (OPA) lung and envelope (Env (show ERVW-1 Proteins)) of Jaagsiekte sheep retrovirus (JSRV) transfected NIH 3T3 cells.

  5. Taken together, our findings imply that KLF15 possesses potential anti-hypertrophic and anti-fibrotic functions, possibly via regulation of cell death pathways and the inhibition of Akt/mTOR axis. KLF15 may constitute an efficient candidate drug for the treatment of heart failure and other cardiovascular diseases.

  6. mTOR is required for early ID-induced thyroid microvascular activation. AMPK negatively regulates this pathway, which may account for the transient nature of ID-induced TSH-independent vascular effects under benign conditions.

  7. establish a non-canonical oncogenic role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells

  8. Taken together, our data demonstrate the importance of CD40 (show CD40 Proteins) signaling in the conversion of CTL exhaustion and its ability to enhance PD-1 (show PDCD1 Proteins) antagonist action in rescuing exhausted CTLs in chronic infection.

  9. 4-PBA reverses autophagic dysfunction and improves insulin (show INS Proteins) sensitivity in adipose tissue of obese mice via Akt (show AKT1 Proteins)/mTOR signaling partly, which could be regarded as novel opportunities for treatment of insulin (show INS Proteins) resistance.

  10. Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta (show PRKCZ Proteins)) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Proteins) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin protein) and Ccnd2 (cyclin-D2 (show CCND2 Proteins)).

Zebrafish Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.

  2. By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.

  3. Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish

  4. In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).

  5. TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.

  6. in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine

Pig (Porcine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

  2. Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).

  3. AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  4. Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.

  5. mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).

  6. L-Glutamine enhances enterocyte growth via activation of the mTOR.

  7. Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.

  8. Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.

  9. Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.

  10. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (show PRKAA1 Proteins)/ERK (show MAPK1 Proteins)/TSC2/mTOR signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) interaction partners

  1. These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.

  2. 14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.

  3. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.

  4. Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.

  5. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.

  6. stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates

  7. data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.

  8. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner

  9. mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.

MTOR (FRAP1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.

Alternative names and synonyms associated with MTOR (FRAP1)

  • mechanistic target of rapamycin (serine/threonine kinase) (MTOR)
  • mechanistic target of rapamycin (serine/threonine kinase) (Mtor)
  • mechanistic target of rapamycin (serine/threonine kinase) (mtor)
  • 2610315D21Rik protein
  • AI327068 protein
  • flat protein
  • FRAP protein
  • frap1 protein
  • FRAP2 protein
  • RAFT1 protein
  • RAPT1 protein
  • tor protein
  • wu:fc22h08 protein

Protein level used designations for FRAP1

FK506 binding protein 12-rapamycin associated protein 1 , FK506 binding protein 12-rapamycin associated protein 2 , FK506-binding protein 12-rapamycin complex-associated protein 1 , FKBP-rapamycin associated protein , FKBP12-rapamycin complex-associated protein 1 , mammalian target of rapamycin , rapamycin and FKBP12 target 1 , rapamycin associated protein FRAP2 , rapamycin target protein 1 , serine/threonine-protein kinase mTOR , FKBP-rapamycin associated protein (FRAP) , FKBP-rapamycin-associated protein FRAP , FKBP12-rapamycin complex-associated protein , angiopoietin-like factor CDT6 , RAPT1 , rapamycin and FKBP12 target-1 protein , target of rapamycin

GENE ID SPECIES
100051341 Equus caballus
419455 Gallus gallus
2475 Homo sapiens
56717 Mus musculus
56718 Rattus norvegicus
324254 Danio rerio
478232 Canis lupus familiaris
100127359 Sus scrofa
100139219 Bos taurus
100860902 Capra hircus
100271659 Ovis aries
Selected quality suppliers for MTOR Proteins (FRAP1)
Did you look for something else?