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Browse our anti-PIK3CA (PIK3CA) Antibodies

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Antibodies (PIK3CA)
On www.antibodies-online.com are 158 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Antibodies from 26 different suppliers available. Additionally we are shipping PIK3CA Kits (6) and PIK3CA Proteins (3) and many more products for this protein. A total of 176 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all antibodies Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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Top referenced anti-PIK3CA Antibodies

  1. Human Monoclonal PIK3CA Primary Antibody for IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968518

  2. Chicken Monoclonal PIK3CA Primary Antibody for BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. in Cell 1991 (PubMed)
    Show all 5 references for ABIN967707

  3. Human Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN360445 : Broderick, Di, Parrett, Samuels, Cummins, McLendon, Fults, Velculescu, Bigner, Yan: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. in Cancer research 2004 (PubMed)
    Show all 4 references for ABIN360445

  4. Human Monoclonal PIK3CA Primary Antibody for ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009 (PubMed)
    Show all 3 references for ABIN969555

  5. Human Polyclonal PIK3CA Primary Antibody for IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN392560

  6. Human Polyclonal PIK3CA Primary Antibody for EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. in Oncogene 2008 (PubMed)
    Show all 3 references for ABIN360221

  7. Human Polyclonal PIK3CA Primary Antibody for FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. in Nature immunology 2009 (PubMed)
    Show all 3 references for ABIN1882113

  8. Human Polyclonal PIK3CA Primary Antibody for IHC, ELISA - ABIN334459 : Lopez-Knowles, Hernandez, Malats, Kogevinas, Lloreta, Carrato, Tardon, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. in Cancer research 2006 (PubMed)
    Show all 2 references for ABIN334459

  9. Human Monoclonal PIK3CA Primary Antibody for EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN1108651

  10. Cow (Bovine) Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN375147 : Abubaker, Bavi, Al-Haqawi, Jehan, Munkarah, Uddin, Al-Kuraya: PIK3CA alterations in Middle Eastern ovarian cancers. in Molecular cancer 2009 (PubMed)

More Antibodies against PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. demonstrated that despite having both Kras and Pik3ca mutations at the time of tumor initiation from loss of APC (show APC Antibodies)

  2. Chronic CoQ(10) supplementation attenuates aspects of diabetic cardiomyopathy, even in a setting of reduced cardiac PI3K(p110alpha) protective signaling

  3. A subgroup of colon cancers might arise in the setting of activated PI3K, as seen in a PIK3CA mutant mouse model.

  4. p110a as well as p110d Class IA PI3Ks are important to immune regulation; inhibition of both subunits may be an effective therapeutic approach in inflammatory autoimmune diseases like rheumatoid arthritis.

  5. Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.

  6. Study demonstrates the oncogenic cooperation between PI3K and Yap (show YAP1 Antibodies) pathways along liver carcinogenesis. The PIK3CA/Yap (show YAP1 Antibodies) mouse represents an important preclinical liver tumor model.

  7. Data show that the RNA-binding protein lin28a (show LIN28A Antibodies)/microRNA let-7a axis regulated glucose metabolism in part through the insulin (show INS Antibodies)-PI3K-mTOR (show FRAP1 Antibodies) pathway.

  8. Data show that PI3 kinase is an attractive therapeutic target in malignancies induced by proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-Kit (show KIT Antibodies) mutations.

  9. ARID1A (show ARID1A Antibodies) and PIK3CA mutations cooperate to promote tumour growth through sustained IL-6 (show IL6 Antibodies) overproduction.

  10. Cone-specific deletion of p110alpha resulted in cone degeneration.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. analysis of ARID1A (show ARID1A Antibodies), CDH1 (show CDH1 Antibodies), cMET and PIK3CA expression and target-related microRNA expression in gastric cancer

  2. The FGFR3 (show FGFR3 Antibodies), PIK3CA, TERT (show TERT Antibodies) mutations, along with aberrant DNA methylation (show HELLS Antibodies) patterns, can serve as reliable genetic markers for the diagnosis of urinary bladder cancer. (Review)

  3. PIK3CA mutations detected at high frequencies in breast cancer and mostly associated with better or insignificant outcomes in estrogen receptor (show ESR1 Antibodies)-positive (ER+) early stage breast cancer and tend to be with worse prognosis in ER- disease.

  4. Down-regulation of PIK3 (show PIK3CG Antibodies) is associated with osteoporosis.

  5. Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies) through PI3 kinase/Akt (show AKT1 Antibodies) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells.

  6. patients with mutant PIK3CA had distinct characteristics in age, menopausal status, and histological subtype and have better treatment outcome and less distant metastasis after surgery-based multimodal therapy.

  7. Though Wortmannin was found to nullify the effect of H1047R over the PIK3CA, further studies are required for designing a better compound.

  8. Data show that rapamycin-insensitive companion of mTOR (show RICTOR Antibodies) protein (RICTOR (show RICTOR Antibodies)) plays a central role in phosphatidylinositol 3-kinase (PI3K)/proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (AKT (show AKT1 Antibodies)) pathway in melanocytes and its deregulation could be involved in melanoma development.

  9. Low incidence of PIK3CA mutations in adenocarcinomas of the ampulla of Vater suggest no major role in tumorigenesis.

  10. Data show that leukemia inhibitory factor (LIF (show LIF Antibodies)) signaling promote chemoresistance in cholangiocarcinoma by up-regulating myeloid cell factor-1 (Mcl-1 (show MCL1 Antibodies)) via phosphatidylinositol 3-kinase (PI3K)/c-akt (show AKT1 Antibodies) protein (AKT (show AKT1 Antibodies))-dependent pathway.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (show ITSN1 Antibodies) unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Antibodies)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Antibodies) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Antigen Profile

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) antibody
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) antibody
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) antibody
  • 6330412C24Rik antibody
  • C-P3K antibody
  • caPI3K antibody
  • CLOVE antibody
  • CWS5 antibody
  • MCAP antibody
  • MCM antibody
  • MCMTC antibody
  • p110 antibody
  • p110-alpha antibody
  • p110alpha antibody
  • pi3-k antibody
  • PI3-kinase antibody
  • PI3K antibody
  • PI3K-alpha antibody

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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