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Browse our anti-PIK3CA (PIK3CA) Antibodies

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Antibodies (PIK3CA)
On www.antibodies-online.com are 154 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Antibodies from 27 different suppliers available. Additionally we are shipping PIK3CA Kits (5) and PIK3CA Proteins (3) and many more products for this protein. A total of 170 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all antibodies Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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anti-Mouse (Murine) PIK3CA Antibodies:

anti-Human PIK3CA Antibodies:

anti-Rat (Rattus) PIK3CA Antibodies:

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Top referenced anti-PIK3CA Antibodies

  1. Human Monoclonal PIK3CA Primary Antibody for IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968518

  2. Chicken Monoclonal PIK3CA Primary Antibody for BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. in Cell 1991 (PubMed)
    Show all 5 references for ABIN967707

  3. Human Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN4620510 : Broderick, Di, Parrett, Samuels, Cummins, McLendon, Fults, Velculescu, Bigner, Yan: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. in Cancer research 2004 (PubMed)
    Show all 4 references for ABIN4620510

  4. Human Monoclonal PIK3CA Primary Antibody for ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009 (PubMed)
    Show all 3 references for ABIN969555

  5. Human Polyclonal PIK3CA Primary Antibody for IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN392560

  6. Human Polyclonal PIK3CA Primary Antibody for EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. in Oncogene 2008 (PubMed)
    Show all 3 references for ABIN360221

  7. Human Polyclonal PIK3CA Primary Antibody for FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. in Nature immunology 2009 (PubMed)
    Show all 3 references for ABIN1882113

  8. Human Monoclonal PIK3CA Primary Antibody for EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN1108651

  9. Human Polyclonal PIK3CA Primary Antibody for IHC, ELISA - ABIN334459 : López-Knowles, Hernández, Malats, Kogevinas, Lloreta, Carrato, Tardón, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. in Cancer research 2006 (PubMed)
    Show all 2 references for ABIN334459

  10. Cow (Bovine) Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN375147 : Abubaker, Bavi, Al-Haqawi, Jehan, Munkarah, Uddin, Al-Kuraya: PIK3CA alterations in Middle Eastern ovarian cancers. in Molecular cancer 2009 (PubMed)

More Antibodies against PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Antibodies) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Antibodies)/NF-kappa B (show NFKB1 Antibodies) signaling, and ST6GalNAc I (show ST6GALNAC1 Antibodies) might be a marker for the prognosis and therapy of hepatocarcinoma.

  2. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Antibodies) gene by targeting BMAL1 (show ARNTL Antibodies) and CLOCK.

  3. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Antibodies) signalling is significantly reduced in Pten (show PTEN Antibodies)() versus PIK3CA(H1047R) tumors. Thus, Pten (show PTEN Antibodies)() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  4. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

  5. These data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of vascular malformations.

  6. data demonstrate that the PI3K p110alpha-Akt (show AKT1 Antibodies)/Rac1 and NOX1 (show NOX1 Antibodies) signalling pathways play a pivotal role in VEGF (show VEGFA Antibodies)-induced vascular differentiation and cell migration.

  7. miR (show MLXIP Antibodies)-490-5p functions as a tumour suppressor in renal carcinoma (show TSC2 Antibodies) by targeting PIK3CA

  8. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Antibodies) restricts pre-T cell receptor (show PTCRA Antibodies) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Antibodies) expression and Notch (show NOTCH1 Antibodies)-engagement.

  9. Data show that RNA silencing of CCN family member 1 (show CYR61 Antibodies) protein (CCN1 (show CCNA2 Antibodies)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Antibodies) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  10. Reelin (show RELN Antibodies) thus plays a role in restraining RAS and PI3-kinase promotion of cell motility and potentially tumour metastasis.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. PTEN (show PTEN Antibodies) and PIK3CA were shown to be upregulated by 89 and 76% (western blot), respectively, in the pemetrexed-resistant cell line compared with control cells.

  2. High expression of PI3K is associated with glioma.

  3. PIK3CA mutations are associated with metastatic lung adenocarcinomas.

  4. Data show that zinc finger protein 143 (ZNF143 (show ZNF143 Antibodies)) promotes epithelial-mesenchymal transition (EMT (show ITK Antibodies)) through regulating PI3K/AKT (show AKT1 Antibodies) pathway in gastric cancer (GC) cells.

  5. Mutations in PIK3CA, AKT1 (show AKT1 Antibodies), and PTEN (show PTEN Antibodies) also were less frequently found in cancers with mutations in the DNA guardian, TP53 (show TP53 Antibodies). This observation might seem counterintuitive because increased genome instability might facilitate development and selection of advantageous mutations.

  6. PIK3CA, PTEN (show PTEN Antibodies), and AKT1 (show AKT1 Antibodies) mutations occurred more frequently in the presence of hormone receptor (show NR4A1 Antibodies) overexpression (androgen, progesterone, or estrogen receptor (show ESR1 Antibodies)). PIK3CA mutations were also more common in the HER2 (show ERBB2 Antibodies)-positive than in the HER2 (show ERBB2 Antibodies)-negative group; the opposite pattern was seen for PTEN (show PTEN Antibodies) mutation or PTEN (show PTEN Antibodies) loss

  7. High PI3K expression is associated with prostate cancer.

  8. PIK3CA gene mutations are associated with breast cancer

  9. Study shows that PIK3CA mutation occurs approximately in 45% of breast cancer patients, and are frequent in exon 20 in comparison with exon 9 of the gene. Also, PIK3CA mutations were found significantly associated with low-grade tumors.

  10. Data show that microRNA miR (show MLXIP Antibodies)-221 targets PTEN (show PTEN Antibodies) protein, leading to activation of the PI3K/Akt (show AKT1 Antibodies) pathway.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (show ITSN1 Antibodies) unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Antibodies)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Antibodies) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Antigen Profile

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) antibody
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) antibody
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) antibody
  • 6330412C24Rik antibody
  • C-P3K antibody
  • caPI3K antibody
  • CLOVE antibody
  • CWS5 antibody
  • MCAP antibody
  • MCM antibody
  • MCMTC antibody
  • p110 antibody
  • p110-alpha antibody
  • p110alpha antibody
  • pi3-k antibody
  • PI3-kinase antibody
  • PI3K antibody
  • PI3K-alpha antibody

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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