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Browse our anti-PIK3CA (PIK3CA) Antibodies

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Antibodies (PIK3CA)
On www.antibodies-online.com are 153 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Antibodies from 27 different suppliers available. Additionally we are shipping PIK3CA Kits (6) and PIK3CA Proteins (3) and many more products for this protein. A total of 170 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all antibodies Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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anti-Mouse (Murine) PIK3CA Antibodies:

anti-Human PIK3CA Antibodies:

anti-Rat (Rattus) PIK3CA Antibodies:

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Top referenced anti-PIK3CA Antibodies

  1. Human Monoclonal PIK3CA Primary Antibody for IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968518

  2. Chicken Monoclonal PIK3CA Primary Antibody for BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. in Cell 1991 (PubMed)
    Show all 5 references for ABIN967707

  3. Human Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN4620510 : Broderick, Di, Parrett, Samuels, Cummins, McLendon, Fults, Velculescu, Bigner, Yan: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. in Cancer research 2004 (PubMed)
    Show all 4 references for ABIN4620510

  4. Human Monoclonal PIK3CA Primary Antibody for ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009 (PubMed)
    Show all 3 references for ABIN969555

  5. Human Polyclonal PIK3CA Primary Antibody for IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN392560

  6. Human Polyclonal PIK3CA Primary Antibody for EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. in Oncogene 2008 (PubMed)
    Show all 3 references for ABIN360221

  7. Human Polyclonal PIK3CA Primary Antibody for FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. in Nature immunology 2009 (PubMed)
    Show all 3 references for ABIN1882113

  8. Human Monoclonal PIK3CA Primary Antibody for EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN1108651

  9. Human Polyclonal PIK3CA Primary Antibody for FACS, IF (p) - ABIN677198 : Paul-Samojedny, Suchanek, Borkowska, Pude?ko, Owczarek, Kowalczyk, Machnik, Fila-Dani?ow, Kowalski: Knockdown of AKT3 (PKB?) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells. in BioMed research international 2014 (PubMed)

  10. Cow (Bovine) Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN375147 : Abubaker, Bavi, Al-Haqawi, Jehan, Munkarah, Uddin, Al-Kuraya: PIK3CA alterations in Middle Eastern ovarian cancers. in Molecular cancer 2009 (PubMed)

More Antibodies against PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. The mRNA levels of leptin (show LEP Antibodies) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  2. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Antibodies) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Antibodies)/NF-kappa B (show NFKB1 Antibodies) signaling, and ST6GalNAc I (show ST6GALNAC1 Antibodies) might be a marker for the prognosis and therapy of hepatocarcinoma.

  3. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (show GC Antibodies) gene by targeting BMAL1 (show ARNTL Antibodies) and CLOCK.

  4. Analysis of 18 signalling signatures revealed that PI3K signalling is significantly induced whereas EGFR (show EGFR Antibodies) signalling is significantly reduced in Pten (show PTEN Antibodies)() versus PIK3CA(H1047R) tumors. Thus, Pten (show PTEN Antibodies)() and PIK3CA(H1047R) tumors exhibit discernable differences that may impact tumorigenesis and response to therapy.

  5. activating PIK3CA mutations gives rise to sporadic venous malformations in mice, which closely resemble the histology of the human disease.

  6. These data demonstrate a causal relationship between activating Pik3ca mutations and the genesis of vascular malformations.

  7. data demonstrate that the PI3K p110alpha-Akt (show AKT1 Antibodies)/Rac1 and NOX1 (show NOX1 Antibodies) signalling pathways play a pivotal role in VEGF (show VEGFA Antibodies)-induced vascular differentiation and cell migration.

  8. miR (show MLXIP Antibodies)-490-5p functions as a tumour suppressor in renal carcinoma (show TSC2 Antibodies) by targeting PIK3CA

  9. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Antibodies) restricts pre-T cell receptor (show PTCRA Antibodies) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Antibodies) expression and Notch (show NOTCH1 Antibodies)-engagement.

  10. Data show that RNA silencing of CCN family member 1 (show CYR61 Antibodies) protein (CCN1 (show CCNA2 Antibodies)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Antibodies) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Bis (show BAG3 Antibodies)(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate induced the activation of both PI3K/AKT (show AKT1 Antibodies) and MAPK/ERK (show MAPK1 Antibodies) signaling pathways dose- and time-dependently.

  2. PIK3CA and AKT1 (show AKT1 Antibodies) are frequently mutated in Hidradenoma papilliferum (HP) tumours (29% and 14%, respectively). PIK3CA/AKT1 (show AKT1 Antibodies) pathway alterations in HP further support the hypothesis that HP is the vulvar (anogenital mammary-like gland) analogue of breast intraductal papilloma.

  3. observations during clinical tumor genotyping suggest that when other pro-oncogenic pathways are mutated along with PIK3CA, then, PIK3CA inhibition alone may not be effective and combination therapy may be warranted

  4. Fulvestrant plus palbociclib was associated with significant and consistent improvement in progression-free survival compared with fulvestrant plus placebo, irrespective of the degree of endocrine resistance, hormone-receptor (show NR4A1 Antibodies) expression level, and PIK3CA mutational status. The combination could be considered as a therapeutic option for patients with HER2 (show ERBB2 Antibodies)-negative breast cancer

  5. Findings show that calmodulin (CaM (show CALM1 Antibodies)) stimulates phosphoinositide-3-kinase (PI3K) lipid kinase activity by binding MARCKS (show MARCKS Antibodies) and displacing it from phosphatidylinositol 4,5-bisphosphate (PIP2) headgroups, thereby releasing free PIP2 that recruits active PI3K to the membrane and serves as the substrate for the generation of phosphatidylinositol 3,4,5-trisphosphate (PIP3).

  6. PIK3CA mutation is associated with salivary duct carcinoma.

  7. PIK3CA E545K/E542K mutations are associated with everolimus resistance in breast cancer.

  8. A recursively partitioned mixture model of all 3 somatic alteration burden measures resulted in classes of tumors whose epigenetic and genetic burden profile were associated with the PAM50 subtype and mutations in TP53 (show TP53 Antibodies), PIK3CA, and CDH1 (show CDH1 Antibodies)

  9. Combined inhibition of PI3K and PARP (show COL11A2 Antibodies) effectively synergized to block the growth of three wild-type PIK3CA ovarian cancer cell lines and explants of a primary ovarian tumor specimen.

  10. PI3K protein was expressed in 81.3% (91/112) of all ESCC samples, whereas it was found in only 4.9% (5/56) of adjacent normal cells.PIK3CA gene mutations were highly correlated with age, tobacco use, and clinical stage (p<0.05), but not with gender, location, alcohol use, lymph node metastasis, or degree of differentiation. PI3K protein expression was not statistically correlated with PIK3CA gene mutations.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (show ITSN1 Antibodies) unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Antibodies)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Antibodies) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Antigen Profile

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) antibody
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) antibody
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) antibody
  • 6330412C24Rik antibody
  • C-P3K antibody
  • caPI3K antibody
  • CLOVE antibody
  • CWS5 antibody
  • MCAP antibody
  • MCM antibody
  • MCMTC antibody
  • p110 antibody
  • p110-alpha antibody
  • p110alpha antibody
  • pi3-k antibody
  • PI3-kinase antibody
  • PI3K antibody
  • PI3K-alpha antibody

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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