Browse our anti-PIK3CA (PIK3CA) Antibodies

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Antibodies (PIK3CA)
On www.antibodies-online.com are 163 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Antibodies from 29 different suppliers available. Additionally we are shipping PIK3CA Kits (10) and PIK3CA Proteins (4) and many more products for this protein. A total of 186 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all antibodies Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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Most Popular Reactivities for anti-PIK3CA (PIK3CA) Antibodies

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anti-Mouse (Murine) PIK3CA Antibodies:

anti-Human PIK3CA Antibodies:

anti-Rat (Rattus) PIK3CA Antibodies:

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Top referenced anti-PIK3CA Antibodies

  1. Human Monoclonal PIK3CA Primary Antibody for IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 968518

  2. Chicken Monoclonal PIK3CA Primary Antibody for BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. in Cell 1991 (PubMed)
    Show all 5 references for 967707

  3. Human Polyclonal PIK3CA Primary Antibody for EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. in Oncogene 2008 (PubMed)
    Show all 3 references for 360221

  4. Human Monoclonal PIK3CA Primary Antibody for ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009 (PubMed)
    Show all 3 references for 969555

  5. Human Polyclonal PIK3CA Primary Antibody for IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002 (PubMed)
    Show all 3 references for 392560

  6. Human Polyclonal PIK3CA Primary Antibody for FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. in Nature immunology 2009 (PubMed)
    Show all 3 references for 1882113

  7. Human Polyclonal PIK3CA Primary Antibody for IHC, ELISA - ABIN334459 : López-Knowles, Hernández, Malats, Kogevinas, Lloreta, Carrato, Tardón, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. in Cancer research 2006 (PubMed)
    Show all 2 references for 334459

  8. Human Monoclonal PIK3CA Primary Antibody for EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. in Oncogene 2004 (PubMed)
    Show all 2 references for 1108651

  9. Human Polyclonal PIK3CA Primary Antibody for IF (p), IHC (p) - ABIN677198 : Paul-Samojedny, Suchanek, Borkowska, Pude?ko, Owczarek, Kowalczyk, Machnik, Fila-Dani?ow, Kowalski: Knockdown of AKT3 (PKB?) and PI3KCA suppresses cell viability and proliferation and induces the apoptosis of glioblastoma multiforme T98G cells. in BioMed research international 2014 (PubMed)

More Antibodies against PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Studies indicate that the Pten (show PTEN Antibodies)+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten (show PTEN Antibodies) is a key regulatory player in the PI3K/PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies) pathway.

  2. our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (show PDPK1 Antibodies) and TGFb (show TGFB1 Antibodies) signaling in advanced HNSCC patients with PIK3CA amplification

  3. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (show HSP90 Antibodies) and the PI3K/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway in prostate cancer.

  4. Data indicate that chlorogenic acid (CGA (show CGA Antibodies)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (show AKT1 Antibodies)-mediated activation of Nrf2 (show NFE2L2 Antibodies)/HO-1 (show HMOX1 Antibodies) pathway, which may be an effective drug in treatment of osteoporosis.

  5. Data show that macrophage M2 polarization was mediated through PTEN (show PTEN Antibodies)/PI3k/AKT (show AKT1 Antibodies) pathway activation.

  6. Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.

  7. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (show AGGF1 Antibodies) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)

  8. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (show PRKAA2 Antibodies)

  9. The mRNA levels of leptin (show LEP Antibodies) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  10. Results suggest a role of ST6GalNAc I (show ST6GALNAC1 Antibodies) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (show AKT1 Antibodies)/NF-kappa B (show NFKB1 Antibodies) signaling, and ST6GalNAc I (show ST6GALNAC1 Antibodies) might be a marker for the prognosis and therapy of hepatocarcinoma.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. High PI3K expression is associated with melanoma.

  2. Data indicate that PI3K pathway mutation predicts longer time to local progression after radioembolization of colorectal liver metastases.

  3. Oncogenic beta-catenin (show CTNNB1 Antibodies) and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.

  4. Results indicate that p110alpha primarily mediates PI3K/AKT (show AKT1 Antibodies) signaling in HER2 (show ERBB2 Antibodies)+ PTEN (show PTEN Antibodies) deficient breast tumors whereas p110beta conditionally mediates HER2 (show ERBB2 Antibodies)/PI3K signaling in the absence of p110alpha.

  5. Cytokines IL-2 (show IL2 Antibodies)/7/9 stimulation activates PI3K/Akt (show AKT1 Antibodies) pathways downstream of Ras in RasGRP1 (show RASGRP1 Antibodies) T-cell acute lymphoblastic leukemia (T-ALL).

  6. This study revealed that (1) PIK3CA hotspot mutations occurred with low frequency in gastric cancer; (2) PIK3CA hotspot mutations were not directly associated with PI3K pathway activation; and (3) p-AKT (show AKT1 Antibodies) (+) may be a biomarker for better outcomes for gastric cancer patients undergoing gastrectomy regardless of the PIK3CA mutation status.

  7. Findings indicate that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1 (show PDLIM7 Antibodies)), PI3K/AKT (show AKT1 Antibodies), miR (show MLXIP Antibodies)-21 and PTEN (show PTEN Antibodies) constitute a positive feedback loop and have a key role in LMP1 (show PDLIM7 Antibodies)-induced cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)).

  8. Data suggest that Lys-776 (in the P-loop of PIK3CA) is critical for autophosphorylation in PIK3CA/PIK3R1 heterodimer; both His-936 and His-917 (in the activation and catalytic loops of PIK3CA) are important catalytically, but appear to have different functions; bisubstrate kinetic analysis of PIK3CA/PIK3R1 heterodimer indicates an ordered sequential mechanism.

  9. PIK3CA mutation is associated with endometrial carcinoma progression and abdominopelvic metastasis.

  10. Tetraarsenic hexoxide (As4O6) induced G2/M arrest, apoptosis and autophagic cell death through PI3K/Akt (show AKT1 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways alteration in SW620 colon cancer cells.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (show ITSN1 Antibodies) unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Antibodies)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Antibodies) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Antigen Profile

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) antibody
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) antibody
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) antibody
  • 6330412C24Rik antibody
  • C-P3K antibody
  • caPI3K antibody
  • CLOVE antibody
  • CWS5 antibody
  • MCAP antibody
  • MCM antibody
  • MCMTC antibody
  • p110 antibody
  • p110-alpha antibody
  • p110alpha antibody
  • pi3-k antibody
  • PI3-kinase antibody
  • PI3K antibody
  • PI3K-alpha antibody

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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