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Browse our anti-PIK3CA (PIK3CA) Antibodies

Full name:
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Antibodies (PIK3CA)
On www.antibodies-online.com are 150 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Antibodies from 27 different suppliers available. Additionally we are shipping PIK3CA Kits (5) and PIK3CA Proteins (3) and many more products for this protein. A total of 167 PIK3CA products are currently listed.
Synonyms:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
list all antibodies Gene Name GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
PIK3CA 170911  

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Most Popular Reactivities for anti-PIK3CA (PIK3CA) Antibodies

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anti-Mouse (Murine) PIK3CA Antibodies:

anti-Human PIK3CA Antibodies:

anti-Rat (Rattus) PIK3CA Antibodies:

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Top referenced anti-PIK3CA Antibodies

  1. Human Monoclonal PIK3CA Primary Antibody for IF, WB - ABIN968518 : Funaki, Katagiri, Kanda, Anai, Nawano, Ogihara, Inukai, Fukushima, Ono, Yazaki, Kikuchi, Oka, Asano: p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968518

  2. Chicken Monoclonal PIK3CA Primary Antibody for BI, IP - ABIN967707 : Cantley, Auger, Carpenter, Duckworth, Graziani, Kapeller, Soltoff: Oncogenes and signal transduction. in Cell 1991 (PubMed)
    Show all 5 references for ABIN967707

  3. Human Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN360445 : Broderick, Di, Parrett, Samuels, Cummins, McLendon, Fults, Velculescu, Bigner, Yan: Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. in Cancer research 2004 (PubMed)
    Show all 4 references for ABIN360445

  4. Human Monoclonal PIK3CA Primary Antibody for ICC, FACS - ABIN969555 : Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009 (PubMed)
    Show all 3 references for ABIN969555

  5. Human Polyclonal PIK3CA Primary Antibody for IHC (p), WB - ABIN392560 : Singh, Reddy, Goberdhan, Walsh, Dao, Ngai, Chou, O-Charoenrat, Levine, Rao, Stoffel: p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. in Genes & development 2002 (PubMed)
    Show all 3 references for ABIN392560

  6. Human Polyclonal PIK3CA Primary Antibody for EIA, WB - ABIN360221 : Zhao, Vogt: Class I PI3K in oncogenic cellular transformation. in Oncogene 2008 (PubMed)
    Show all 3 references for ABIN360221

  7. Human Polyclonal PIK3CA Primary Antibody for FACS, IHC (p) - ABIN1882113 : Tiwari, Choi, Matsuzawa, Pypaert, MacMicking: Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. in Nature immunology 2009 (PubMed)
    Show all 3 references for ABIN1882113

  8. Human Polyclonal PIK3CA Primary Antibody for IHC, ELISA - ABIN334459 : Lopez-Knowles, Hernandez, Malats, Kogevinas, Lloreta, Carrato, Tardon, Serra, Real: PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. in Cancer research 2006 (PubMed)
    Show all 2 references for ABIN334459

  9. Human Monoclonal PIK3CA Primary Antibody for EIA, FACS - ABIN1108651 : Hwang, Ryu, Chung, Kim, Park, Chae, Chae, Kwon: Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. in Oncogene 2004 (PubMed)
    Show all 2 references for ABIN1108651

  10. Cow (Bovine) Polyclonal PIK3CA Primary Antibody for EIA, IHC (p) - ABIN375147 : Abubaker, Bavi, Al-Haqawi, Jehan, Munkarah, Uddin, Al-Kuraya: PIK3CA alterations in Middle Eastern ovarian cancers. in Molecular cancer 2009 (PubMed)

More Antibodies against PIK3CA Interaction Partners

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. miR (show MLXIP Antibodies)-490-5p functions as a tumour suppressor in renal carcinoma (show TSC2 Antibodies) by targeting PIK3CA

  2. Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb (show ITPKB Antibodies) restricts pre-T cell receptor (show PTCRA Antibodies) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (show PTCRA Antibodies) expression and Notch (show NOTCH1 Antibodies)-engagement.

  3. Data show that RNA silencing of CCN family member 1 (show CYR61 Antibodies) protein (CCN1 (show CCNA2 Antibodies)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling in mouse pup model of oxyge (show AKT1 Antibodies)n-induced retinopathy (OIR).

  4. Reelin (show RELN Antibodies) thus plays a role in restraining RAS and PI3-kinase promotion of cell motility and potentially tumour metastasis.

  5. demonstrated that despite having both Kras and Pik3ca mutations at the time of tumor initiation from loss of APC (show APC Antibodies)

  6. Chronic CoQ(10) supplementation attenuates aspects of diabetic cardiomyopathy, even in a setting of reduced cardiac PI3K(p110alpha) protective signaling

  7. A subgroup of colon cancers might arise in the setting of activated PI3K, as seen in a PIK3CA mutant mouse model.

  8. p110a as well as p110d Class IA PI3Ks are important to immune regulation; inhibition of both subunits may be an effective therapeutic approach in inflammatory autoimmune diseases like rheumatoid arthritis.

  9. Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation.

  10. Study demonstrates the oncogenic cooperation between PI3K and Yap (show YAP1 Antibodies) pathways along liver carcinogenesis. The PIK3CA/Yap (show YAP1 Antibodies) mouse represents an important preclinical liver tumor model.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. Suggest that copy number loss of Variation_91720 in PIK3CA predicts risk of esophageal squamous cell carcinoma.

  2. PIK3CA rs17849071 and rs17849079 polymorphisms may increase the risk of hepatocellular carcinoma.

  3. It was suggested that somatic point mutations in BRAF (show BRAF Antibodies), CDKN2A (show CDKN2A Antibodies) and PI3KCA do not participate in the oncogenesis of Medullary thyroid carcinoma

  4. miR (show MLXIP Antibodies)-490-5p functions as a tumour suppressor in renal carcinoma (show TSC2 Antibodies) by targeting PIK3CA

  5. in a high number of HNSCC tumours, PI3K/Akt (show AKT1 Antibodies) signalling is activated by different molecules or by the combination of these molecules.

  6. none of the nine tested SNPs of PIK3CA was associated with susceptibility to oral squamous cell carcinoma in the studied population.

  7. PIK3CA Mutations are associated with Head and Neck Squamous Cell Carcinoma.

  8. Our study demonstrates that the IGF1R (show IGF1R Antibodies)/p110b/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) axis confers resistance to BYL719 in PIK3CA mutant breast cancers

  9. Findings of frequent mutations in CDKN2A (show CDKN2A Antibodies), NOTCH1 (show NOTCH1 Antibodies), PIK3CA, and EGFR (show EGFR Antibodies) (all in excess (show RCC1 Antibodies) of 20%) point to potential therapeutic avenues. Trials of targeted therapies directed toward these mutations should be explored.

  10. As depicted in Figure 3, APC (show APC Antibodies) (25%) followed by KRAS (20%), TP53 (show TP53 Antibodies) (14%), and PIK3CA (11%) were the most frequently mutated genes.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) interaction partners

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain (show ITSN1 Antibodies) unfolding.

  2. PI3K has a role in activation of 5'-AMP (show TMPRSS5 Antibodies)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (show PIK3C2A Antibodies) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Antigen Profile

Antigen Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) antibody
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822) antibody
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca) antibody
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca) antibody
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) antibody
  • 6330412C24Rik antibody
  • C-P3K antibody
  • caPI3K antibody
  • CLOVE antibody
  • CWS5 antibody
  • MCAP antibody
  • MCM antibody
  • MCMTC antibody
  • p110 antibody
  • p110-alpha antibody
  • p110alpha antibody
  • pi3-k antibody
  • PI3-kinase antibody
  • PI3K antibody
  • PI3K-alpha antibody

Protein level used designations for PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPECIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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