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The present study was aimed at investigating whether the miR (show MLXIP Proteins)-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 (show MAPKSP1 Proteins) gene affected the gastric cancer risk.
we demonstrate that the MAPK (show MAPK1 Proteins) scaffold protein (show HOMER1 Proteins) MEK partner 1 (MP1 (show MAPKSP1 Proteins)) is important for gastrin (show GAST Proteins)-induced phosphorylation of ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) and that MP1 promotes gastrin (show GAST Proteins)-induced proliferation of AGS (show JAG1 Proteins)-GR cells
identified polymorphisms in LAMTOR2 (show LAMTOR2 Proteins) and LAMTOR3 (show MAPKSP1 Proteins) do not seem to play a relevant role in breast cancer
A complex encoded by the MAPKSP1 (show MAPKSP1 Proteins), ROBLD3 (show LAMTOR2 Proteins), and c11orf59 (show LAMTOR1 Proteins) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
We investigated the neuroprotective effect of glial-derived neurotrophic factor (GDNF) upon alcohol-exposed B92 cultures, as well as the role of the cytoskeleton and mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) pathways in this effect.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
MAPK scaffold protein 1
, MEK binding partner 1
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
, mitogen-activated protein kinase kinase 1 interacting protein 1
, mitogen-activated protein kinase scaffold protein 1
, ragulator complex protein LAMTOR3