PITRM1 Protein (AA 1-124) (His tag)
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- Target See all PITRM1 Proteins
- PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-124
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PITRM1 protein is labelled with His tag.
- Purpose
- Recombinant Human MEK-Binding Protein 1/MP1/MAPKSP1 (N-6His)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV VEVS
- Characteristics
- Recombinant Human Mitogen-Activated Protein Kinase Scaffold Protein 1/MAPKSP1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Val124) of Human LAMTOR3 fused with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Sterility
- 0.2 μm filtered
- Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product PITRM1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 5 mM DTT, 30 % Glycerol, pH 8.0.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Storage
- -80 °C
- Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - Expiry Date
- 6 months
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- Target
- PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))
- Alternative Name
- MP1 (PITRM1 Products)
- Synonyms
- MP1 Protein, PreP Protein, 2310012C15Rik Protein, AA410010 Protein, MP-1 Protein, Ntup1 Protein, mKIAA1104 Protein, PITRM1 Protein, wu:fa03d09 Protein, zgc:55469 Protein, pitrilysin metallopeptidase 1 Protein, pitrilysin metallepetidase 1 Protein, pitrilysin metallopeptidase 1 L homeolog Protein, PITRM1 Protein, Pitrm1 Protein, pitrm1.L Protein, pitrm1 Protein
- Sub Type
- Fusionprotein
- Background
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Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
Alternative Names: Ragulator Complex Protein LAMTOR3, Late Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 3, MEK-Binding Partner 1, Mp1, Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1, Mitogen-Activated Protein Kinase Scaffold Protein 1, LAMTOR3, M - Molecular Weight
- 15.78 kDa
- UniProt
- Q9UHA4
- Pathways
- PI3K-Akt Signaling, SARS-CoV-2 Protein Interactome
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