Browse our PPP2R4 Proteins (PPP2R4)

On are 9 Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Proteins from 5 different suppliers available. Additionally we are shipping PPP2R4 Antibodies (69) and PPP2R4 Kits (8) and many more products for this protein. A total of 92 PPP2R4 products are currently listed.
2610042B21Rik, 6330556D22Rik, C77440, N28142, PP2A, PR53, PR65, PTPA, PTPRA
list all proteins Gene Name GeneID UniProt
PPP2R4 51792 Q76MZ3
PPP2R4 5524 Q15257

PPP2R4 Proteins (PPP2R4) by Origin

More Proteins for PPP2R4 Interaction Partners

Mouse (Murine) Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) interaction partners

  1. data indicate that PTPalpha (show PTPRA Proteins) and FAK (show PTK2 Proteins), which are enriched in FAs (show FAS Proteins), interact with IP3R1 (show ITPR1 Proteins) at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  2. oocyte-specific deletion of Ppp2r1a (show PPP2R1A Proteins) led to severe female subfertility without affecting follicle survival, growth, and ovulation.

  3. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.

  4. PP2A (show PPP2R2B Proteins) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (show PLK4 Proteins) autophosphorylation, thus stabilizing Plk4 (show PLK4 Proteins) and promoting centriole duplication

  5. PP2A (show PPP2R2B Proteins)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (show TFAP2A Proteins), CREB (show CREB1 Proteins), ETS-1 (show ETS1 Proteins), and SP-1 (show SP1 Proteins)

  6. Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.

  7. protein phosphatase 2A overexpression in NIH 3T3 cells

  8. T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (show PPP2R2B Proteins) prevents the inhibitory function of CTLA-4 (show CTLA4 Proteins), before TCR-CTLA-4 (show CTLA4 Proteins) coligation.

  9. PP-2A regulation of paxillin (show PXN Proteins) phosphorylation may have a role in controlling tumor cell adherence and motility.

  10. PP2A (show PPP2R2B Proteins) may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A (show PPP2R2B Proteins) B56gamma regulatory subunit reduces irradiation-induced Mdm2 (show MDM2 Proteins) phosphorylation

Human Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) interaction partners

  1. The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (show IFNA Proteins) signaling via increased expression of SOCS3 (show SOCS3 Proteins) and PP2A.

  2. The current study describes a novel pathogenic mechanism of action for human polyomavirus 6 small tumor (sT) antigen which involves binding to protein phosphatase 2A (PP2A) via its WFG motif and zinc binding sites for activation of PP2A's downstream oncogenic pathways (MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)/c-Jun (show JUN Proteins)).

  3. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 (show RASGRF1 Proteins) and DUSP1 (show DUSP1 Proteins)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.

  4. Oncoprotein CIP2A (show KIAA1524 Proteins) is stabilized via interaction with tumor suppressor PP2A/B56

  5. Such effect by miR (show MLXIP Proteins)-429 was again abolished with AMPKalpha1 (show PRKAA1 Proteins) silence or mutation. Together, we propose that PP2A-c silence by miR (show MLXIP Proteins)-429 activates AMPK (show PRKAA1 Proteins) and protects osteoblastic cells from Dex.

  6. PTPalpha (show PTPRA Proteins) is identified as a novel substrate of N-Acetylglucosaminyltransferase V (GnT-V (show MGAT5 Proteins)) and could be a factor regulating promotion of migration in breast cancer cells

  7. This article reviews the involvement of PP2A in the regulation of three cell signaling pathways: wnt (show WNT2 Proteins), mTOR (show FRAP1 Proteins) and MAP kinase (show MAPK1 Proteins), as well as the G1-->S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases. [review]

  8. PP2A-B55 (show MINK1 Proteins) substrates were identified and assigned their temporal order in mitotic exit.

  9. Our results provide a novel mechanistic insight into the activation of Myc (show MYC Proteins) by 27-HC via transcriptional repression of PP2A, SCP1 (show SYCP1 Proteins) and FBW7 (show FBXW7 Proteins) to increase Myc (show MYC Proteins) protein stability in breast cancer cells.

  10. Data show that the truncation promotes glycogen synthase kinase-3beta (GSK-3beta) nuclear translocation and enhances its interaction with protein phosphatase 2A (PP2A), leading to dephosphorylation.

PPP2R4 Protein Profile

Protein Summary

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PPP2R4

  • protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (Ppp2r1a)
  • protein phosphatase 2A activator, regulatory subunit 4 (PPP2R4)
  • protein phosphatase 2A, regulatory subunit B (PR 53) (Ppp2r4)
  • 2610042B21Rik protein
  • 6330556D22Rik protein
  • C77440 protein
  • N28142 protein
  • PP2A protein
  • PR53 protein
  • PR65 protein
  • PTPA protein
  • PTPRA protein

Protein level used designations for PPP2R4

PP2A subunit A isoform PR65-alpha , PP2A subunit A isoform R1-alpha , protein phosphatase PP2A , serine/threonine protein phosphatase A subunit type 2A , serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform , PP2A phosphatase activator , PP2A subunit B' isoform PR53 , phosphotyrosyl phosphatase activator , protein phosphatase 2A, regulatory subunit B' (PR 53) , serine/threonine-protein phosphatase 2A activator , serine/threonine-protein phosphatase 2A regulatory subunit B' , PP2A, subunit B', PR53 isoform , PTPA , serine/threonine-protein phosphatase 2A regulatory subunit 4 , protein tyrosine phosphatase, receptor type, A

51792 Mus musculus
5524 Homo sapiens
514460 Bos taurus
100009404 Oryctolagus cuniculus
110854 Mus musculus
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