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Browse our PPP2R4 Proteins (PPP2R4)

Full name:
Protein Phosphatase 2A Activator, Regulatory Subunit 4 Proteins (PPP2R4)
On are 8 Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) Proteins from 4 different suppliers available. Additionally we are shipping PPP2R4 Antibodies (61) and PPP2R4 Kits (7) and many more products for this protein. A total of 82 PPP2R4 products are currently listed.
2610042B21Rik, 6330556D22Rik, C77440, N28142, PP2A, PR53, PR65, PTPA, PTPRA
list all proteins Gene Name GeneID UniProt
PPP2R4 51792 Q76MZ3
PPP2R4 5524 Q15257

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PPP2R4 Proteins (PPP2R4) by Origin

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More Proteins for PPP2R4 Interaction Partners

Mouse (Murine) Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) interaction partners

  1. data indicate that PTPalpha (show PTPRA Proteins) and FAK (show PTK2 Proteins), which are enriched in FAs (show FAS Proteins), interact with IP3R1 (show ITPR1 Proteins) at adjacent ER sites to spatially sequester IL-1 (show IL1A Proteins)-induced Ca(2 (show CA2 Proteins)+) signalling

  2. oocyte-specific deletion of Ppp2r1a (show PPP2R1A Proteins) led to severe female subfertility without affecting follicle survival, growth, and ovulation.

  3. A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.

  4. PP2A (show PPP2R2B Proteins) (Protein Phosphatase 2A(Twins)) counteracts Plk4 (show PLK4 Proteins) autophosphorylation, thus stabilizing Plk4 (show PLK4 Proteins) and promoting centriole duplication

  5. PP2A (show PPP2R2B Proteins)-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha (show TFAP2A Proteins), CREB (show CREB1 Proteins), ETS-1 (show ETS1 Proteins), and SP-1 (show SP1 Proteins)

  6. Data show that DSB promote PP2A to associate with Ku 70 and Ku 86.

  7. findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3 (show CASP3 Proteins)-dependent apoptosis

  8. oxidative stress regulates the phosphorylation status of nonribosomal rpS3 (show RPS3 Proteins) by both activating PKCdelta (show PKCd Proteins) and blocking the PP2A (show PPP2R2B Proteins) interaction with rpS3 (show RPS3 Proteins)

  9. protein phosphatase 2A overexpression in NIH 3T3 cells

  10. T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A (show PPP2R2B Proteins) prevents the inhibitory function of CTLA-4 (show CTLA4 Proteins), before TCR-CTLA-4 (show CTLA4 Proteins) coligation.

Human Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4) interaction partners

  1. we propose that RhoB could be responsible for early metastatic prevention by inhibiting the EMT (show ITK Proteins)-derived invasiveness of lung cells through the control of PP2A activity.

  2. Cohesin complex (show SMC3 Proteins) is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1 (show SGOL1 Proteins)-dependent PP2A recruitment.

  3. Zinc-alpha2-glycoprotein modulates AKT (show AKT1 Proteins)-dependent insulin (show INS Proteins) signaling in adipocytes by activation of the PP2A phosphatase.

  4. these data reveal the molecular mechanisms of PP2A regulation and highlight the potential of boosting the power of endogenous phosphatases as novel anti-inflammatory strategies to combat asthmatic inflammation.

  5. Transgenic overexpression of myocardial PP2A causes adverse remodeling which coincides with a disruption of the classical Akt (show AKT1 Proteins)/GSK3/beta-catenin (show CTNNB1 Proteins) pathway under baseline conditions that is restored to normal values in chronic myocardial infarction.

  6. an increase in the phosphorylation level of PTPalphaTyr789 by its upstream activator, FAKDel33, leading to Src (show SRC Proteins) activation in certain breast cancer cells, which has significant implications for metastatic potential.

  7. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli (show GLI1 Proteins) transcriptional activity.

  8. The roles of protein phosphatases including MAPK phosphatase-1 (MKP-1 (show DUSP1 Proteins)) and protein phosphatase type 2A (PP2A) in modulating p38MAPK (show MAPK14 Proteins) activation and downstream TNF-alpha (show TNF Proteins) expressions in primary human monocyte-derived macrophages, were examined.

  9. The invariant C-terminal residues of the catalytic subunit can act as affinity enhancer for different PP2A interaction partners, including PTPA, and a different 'code' of posttranslational modifications can favour interactions to one subunit over others.

  10. REDD1 (show DDIT4 Proteins) may act as a targeting protein for the catalytic subunit of PP2A

PPP2R4 Protein Profile

Protein Summary

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PPP2R4

  • protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (Ppp2r1a)
  • protein phosphatase 2A activator, regulatory subunit 4 (PPP2R4)
  • protein phosphatase 2A, regulatory subunit B (PR 53) (Ppp2r4)
  • 2610042B21Rik protein
  • 6330556D22Rik protein
  • C77440 protein
  • N28142 protein
  • PP2A protein
  • PR53 protein
  • PR65 protein
  • PTPA protein
  • PTPRA protein

Protein level used designations for PPP2R4

PP2A subunit A isoform PR65-alpha , PP2A subunit A isoform R1-alpha , protein phosphatase PP2A , serine/threonine protein phosphatase A subunit type 2A , serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform , PP2A phosphatase activator , PP2A subunit B' isoform PR53 , phosphotyrosyl phosphatase activator , protein phosphatase 2A, regulatory subunit B' (PR 53) , serine/threonine-protein phosphatase 2A activator , serine/threonine-protein phosphatase 2A regulatory subunit B' , PP2A, subunit B', PR53 isoform , PTPA , serine/threonine-protein phosphatase 2A regulatory subunit 4 , protein tyrosine phosphatase, receptor type, A

51792 Mus musculus
5524 Homo sapiens
514460 Bos taurus
100009404 Oryctolagus cuniculus
110854 Mus musculus
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