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Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P (show S1PR1 ELISA Kits)) in acute lung injury, and the role in this process of S1P (show S1PR1 ELISA Kits) lyase has been described. (Review)
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis (show LBR ELISA Kits) and adrenal insufficiency
deleting SPL in CD11c (show ITGAX ELISA Kits)(+) dendritic cells (DCs), rather than thymic epithelial cells or other stromal cells, disrupts the sphingosine-1-phosphate gradient, preventing egress.
Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.
Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.
upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 ELISA Kits) lyase-deficient MEFs
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 ELISA Kits)-activated microRNAs.
Findings suggest that sphingosine phosphate lyase (S1P (show S1PR1 ELISA Kits) lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1 (show S1PR1 ELISA Kits)).
Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase (show ALD ELISA Kits)) mRNA is significantly increased in the periinfarct cortex.
Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.
results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon (show IKBKE ELISA Kits) and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Exposure to the combination of 100 muM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERb (show ESR2 ELISA Kits) and VDR (show CYP27B1 ELISA Kits) expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells..strong overexpression SGPL1, which irreversibly degrades sphingosine-1-phosphate thereby, generating ethanolamine
Overexpression of sphingosine-1-phosphate lyase 1 (SGPL1), reverse the interleukin-8 (IL-8 (show IL8 ELISA Kits)) secretion enhancing effect of microRNA miR (show MLXIP ELISA Kits)-125b in trophoblast cell line HTR8/SVneo cells.
Report a candidate gene (SGPL1) for autosomal recessive Charcot-Marie-Tooth disease with atypical disease course. Studies in patient-derived biosamples suggested that this phenotype is due to partial loss of SGPL1 function. Neuron-specific downregulation of the Drosophila orthologue impaired the morphology of the neuromuscular junction and caused progressive neurodegeneration
increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
SPHK1 (show SPHK1 ELISA Kits):SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 ELISA Kits)), and S1P (show MBTPS1 ELISA Kits) correlated with drug resistance (IC50).
Results show that dissociation of SHP-1 (show PTPN6 ELISA Kits) from spinophilin (show PPP1R9B ELISA Kits) is followed by an increase in the binding of spinophilin (show PPP1R9B ELISA Kits) to PP1 (show PPA1 ELISA Kits).
S1P (show MBTPS1 ELISA Kits) lyase - by facilitating S1P1 (show S1PR1 ELISA Kits) receptor recycling - is essential for S1P (show MBTPS1 ELISA Kits)-mediated sustained signaling
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
sphingosine-1-phosphate lyase 1
, SP-lyase 1
, SPL 1
, sphingosine-1-phosphate aldolase
, sphingosine phosphate lyase 1