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Akirin-2 downregulation increases chemosensitivity in human glioblastomas more efficiently than Twist-1 (show TWIST1 Proteins)
Data demonstrate a previously-unsuspected role for Akirin2 in early cortical development and, given its known nuclear roles, suggest that it may act to regulate gene expression patterns critical for early progenitor cell behavior and cortical neuron production.
The nuclear protein akirin2 has an essential function in B cell activation (show BLNK Proteins) and humoral immune responses.
The IkappaB-zeta (show NFKBIZ Proteins)-Akirin2-BAF60 complex physically links the NF-kappaB (show NFKB1 Proteins) and SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes in innate immune cell activation.
The c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
, fourteen-three-three beta interactant 1
, fourteen-three-three beta interacting-protein 1