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Akirin-2 downregulation increases chemosensitivity in human glioblastomas more efficiently than Twist-1 (show TWIST1 Proteins)
The nuclear protein akirin2 has an essential function in B cell activation (show BLNK Proteins) and humoral immune responses.
The IkappaB-zeta (show NFKBIZ Proteins)-Akirin2-BAF60 complex physically links the NF-kappaB (show NFKB1 Proteins) and SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes in innate immune cell activation.
The c.*188G>A SNP of akirin 2 might be useful as a DNA marker for longissimus muscle area and marbling scores in Korean native cattle.
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
, fourteen-three-three beta interactant 1
, fourteen-three-three beta interacting-protein 1