Browse our PDCD6 Proteins (PDCD6)

Full name:
Programmed Cell Death 6 Proteins (PDCD6)
On are 16 Programmed Cell Death 6 (PDCD6) Proteins from 8 different suppliers available. Additionally we are shipping PDCD6 Antibodies (79) and PDCD6 Kits (5) and many more products for this protein. A total of 102 PDCD6 products are currently listed.
alg-2, Alg2, AV299538, MA-3, MGC52821, MGC132114, PDCD6, PEF1B, PS2, zgc:63952
list all proteins Gene Name GeneID UniProt
PDCD6 10016 O75340
PDCD6 18570 P12815
Rat PDCD6 PDCD6 308061  

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PDCD6 Proteins (PDCD6) by Origin

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Top referenced PDCD6 Proteins

  1. Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN667892 : Suzuki, Kawasaki, Inuzuka, Okumura, Kakiuchi, Shibata, Wakatsuki, Maki: Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. in Structure (London, England : 1993) 2008 (PubMed)
    Show all 2 references for 667892

  2. Human PDCD6 Protein expressed in Escherichia coli (E. coli) - ABIN1047560 : Kitaura, Matsumoto, Satoh, Hitomi, Maki: Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for 1047560

More Proteins for PDCD6 Interaction Partners

Human Programmed Cell Death 6 (PDCD6) interaction partners

  1. The results suggest that ALG-2 acts as a Ca2 (show CA2 Proteins)+-sensitive adaptor to concentrate and polymerize TFG at endoplasmic reticulum exit sites, supporting a potential role for ALG-2 in COPII-dependent trafficking from the endoplasmic reticulum.

  2. ALG2 has a tumor suppressive role in glioblastoma and might be a potential target for the treatment of glioblastoma.

  3. miR (show MLXIP Proteins)-183 may function as an oncogene (show RAB1A Proteins) and may enhance cell proliferation by targeting PDCD6, implying a potential therapeutic target for this malignancy.

  4. Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma

  5. PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.

  6. Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.

  7. The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.

  8. CHERP (show CHERP Proteins) and ALG-2 participate in regulation of alternative splicing of IP3R1 (show ITPR1 Proteins) pre-mRNA and provide new insights into post-transcriptional regulation of splicing variants in Ca(2 (show CA2 Proteins)+) signaling pathways.

  9. the binding of ALG-2 to IST1 (show IST1 Proteins) is Ca(2 (show CA2 Proteins)+)-dependent

  10. the current study indicates that PDCD6 gene may be a new susceptibility gene to endometriosis.

Mouse (Murine) Programmed Cell Death 6 (PDCD6) interaction partners

  1. ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.

  2. Substitution of either L52 with Ala or F148 with Ser (show SIGLEC1 Proteins) of ALG-2 caused loss of binding abilities to PLSCR3 (show PLSCR3 Proteins) lacking type 1 motif but retained those to PLSCR3 (show PLSCR3 Proteins) lacking type 2 motif

  3. ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)

PDCD6 Protein Profile

Protein Summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.

Alternative names and synonyms associated with PDCD6

  • programmed cell death 6 (pdcd6)
  • programmed cell death 6 (PDCD6)
  • programmed cell death 6 (Pdcd6)
  • alg-2 protein
  • Alg2 protein
  • AV299538 protein
  • MA-3 protein
  • MGC52821 protein
  • MGC132114 protein
  • PDCD6 protein
  • PEF1B protein
  • PS2 protein
  • zgc:63952 protein

Protein level used designations for PDCD6

programmed cell death 6 , programmed cell death protein 6 , apoptosis-linked gene 2 protein , probable calcium-binding protein ALG-2 , ALG-257 , PMP41

380264 Xenopus laevis
393925 Danio rerio
723039 Macaca mulatta
10016 Homo sapiens
18570 Mus musculus
420988 Gallus gallus
609549 Canis lupus familiaris
100125927 Bos taurus
308061 Rattus norvegicus
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